ChemicalBook > CAS DataBase List > RIPK1-IN-7

RIPK1-IN-7

Product Name
RIPK1-IN-7
CAS No.
2300982-44-7
Chemical Name
RIPK1-IN-7
Synonyms
RIPK1-IN-7;RIPK1 inhibitor 7;RIPK1-IN-7, 10 mM in DMSO;1-(5-(4-Amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethoxy)phenyl)ethan-1-one;Ethanone, 1-[5-(4-amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethoxy)phenyl]-;RIPK-1-IN-7,inhibit,TrkA,Mer,Receptor-interacting protein kinases,Flt4,Axl,TrkB,Inhibitor,RIP kinase,RIPK,TrkC,RIPK1 IN 7,RIPK1IN7,HRI
CBNumber
CB95419833
Molecular Formula
C25H22F3N5O2
Formula Weight
481.47
MOL File
2300982-44-7.mol
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RIPK1-IN-7 Property

Boiling point:
724.8±60.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 62.5 mg/mL (129.81 mM); Water: < 0.1 mg/mL (insoluble)
form 
Solid
pka
5.76±0.30(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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RIPK1-IN-7 Chemical Properties,Usage,Production

Biological Activity

RIPK1-IN-7 is a receptor-interacting protein kinase 1 (RIPK1) inhibitor with a Kd of 4 nM and an IC50 of 11 nM. RIPK1-IN-7 has good anti-metastatic activity in an experimental B16 melanoma lung metastasis model.

in vitro

RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC 50 of 2nM.
It displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC 50 s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively.

target

IC50: 11 nM (RIPK1)
Kd: 4 nM (RIPK1)

RIPK1-IN-7 Preparation Products And Raw materials

Raw materials

Preparation Products

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RIPK1-IN-7 Suppliers

China 18 United States 3 Global 21
Shanghai Raise Chemical Technology Co.,Ltd
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15026594951
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0556-5030632
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rs@raise-chem.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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010-60605840
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psaitong@jm-bio.com
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China
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
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China
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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Shanghai hongqu biomedical technology co. LTD
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88888888888
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hongquchem@qq.com
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China
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 15801484223;
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psaitong@jm-bio.com
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Bide Pharmatech Ltd.
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400-1647117 13681763483
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product02@bidepharm.com
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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Henan Alpha Chemical Co., Ltd.
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0371-55013243 15324716602
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2853979810@qq.com
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Nantong QuanYi Biotechnology Co., Ltd
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0513-66337626 18051384581
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
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025-85563444
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RD International Technology Co., Limited
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18024082417
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market@ubiochem.com
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Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.
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025-66061636 18013972705
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Absin Bioscience Inc.
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Proteintech China
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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info@zzsrm.com
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2300982-44-7, RIPK1-IN-7Related Search:


  • RIPK1-IN-7
  • RIPK1 inhibitor 7
  • Ethanone, 1-[5-(4-amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethoxy)phenyl]-
  • RIPK-1-IN-7,inhibit,TrkA,Mer,Receptor-interacting protein kinases,Flt4,Axl,TrkB,Inhibitor,RIP kinase,RIPK,TrkC,RIPK1 IN 7,RIPK1IN7,HRI
  • 1-(5-(4-Amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethoxy)phenyl)ethan-1-one
  • RIPK1-IN-7, 10 mM in DMSO
  • 2300982-44-7