UBCS039

ChemicalBook > CAS DataBase List > UBCS039

Product Name: UBCS039
CAS No.: 358721-70-7
Chemical Name: UBCS039
Synonyms: UBCS039;4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline;Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)-;Autophagy,UBCS039,UBCS 039,inhibit,Sirtuin,Inhibitor,UBCS-039
CBNumber: CB95419868
Molecular Formula: C16H13N3
Formula Weight: 247.29
MOL File: 358721-70-7.mol

Less

UBCS039 Property

Boiling point:: 453.9±45.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : 125 mg/mL (505.48 mM)
pka: 4.66±0.12(Predicted)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0086992
Product name: UBCS039
Purity: 98.13%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0086992
Product name: UBCS039
Purity: 98.13%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0009227
Product name: UBCS-039
Purity: 95.00%
Packaging: 5MG
Price: $458.62
Updated: 2021/12/16

ChemScene

Product number: CS-0086992
Product name: UBCS039
Purity: 98.13%
Packaging: 25mg
Price: $570
Updated: 2021/12/16

ChemScene

Product number: CS-0086992
Product name: UBCS039
Purity: 98.13%
Packaging: 50mg
Price: $960
Updated: 2021/12/16

Less

UBCS039 Chemical Properties,Usage,Production

Biological Activity

UBCS039, the first synthetic SIRT6 activator with EC50 of 38 μM, induces time-dependent activation of autophagy in multiple human tumor cell lines.

in vitro

UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells. It leads to autophagosome accumulation in human cancer cells.UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation.

Western Blot Analysis

Cell Line:	Human H1299 cells.
Concentration:	75 μM.
Incubation Time:	48 and 72 hours.
Result:	Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells.

Cell Proliferation Assay

Cell Line:	Human H1299 cells.
Concentration:	100 μM.
Incubation Time:	48 and 72 hours.
Result:	Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines.

target

Target	Value
SIRT6 (Cell-free assay)	38 μM(EC50)

UBCS039 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

UBCS039 Suppliers

China 42 United States 3 Global 45

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7892
Advantage: 56

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4182
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9708
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 3500
Advantage: 55

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2989
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9838
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9730
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Fax: QQ：3002694073
Email: 3002694073@qq.com
Country: China
ProdList: 10097
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 884
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9412
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 3615
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44486
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4495
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 29778
Advantage: 58

Hefei Mokai Pharmaceutical Technology Co., Ltd

Tel: 18130062233
Email: 3362556465@qq.com
Country: China
ProdList: 8000
Advantage: 58

Wuhan Augda Biotechnology Co., Ltd

Tel: 15071299552
Fax: QQ:262933239
Email: 262933239@qq.com
Country: China
ProdList: 6637
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2815987 13927875076
Fax: 0751-2828607
Email: 3007432263@qq.com
Country: China
ProdList: 9977
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Email: product02@bidepharm.com
Country: China
ProdList: 63720
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6749
Advantage: 58

Changzhou Bojia Biomedical Technology Co., Ltd.

Tel: 2122619822
Email: czbjpharma@126.com
Country: China
ProdList: 18488
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24017
Advantage: 58

Beijing InnoChem Science & Technology Co., Ltd.

Tel: 15652467323 15652467323
Email: sales@inno-chem.com.cn
Country: China
ProdList: 8293
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29803
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 15162312715
Email: sales@szzxbio.com
Country: China
ProdList: 2992
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27996
Advantage: 58

Guangdong Fangxin Biotechnology Co., Ltd.

Tel: 0751-2838688 13376594225
Email: 1276075424@qq.com
Country: China
ProdList: 9937
Advantage: 58

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

Tel: 024-024-88590548 18341751992
Email: 757984502@qq.com
Country: China
ProdList: 888
Advantage: 58

Shaoguan Qicheng Biotechnology Co., Ltd

Tel: 18122215013
Email: 780229652@qq.com
Country: China
ProdList: 945
Advantage: 58

Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
Country: China
ProdList: 5141
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb5@aikonchem.com
Country: China
ProdList: 10529
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29990
Advantage: 58

Wuhan Acumen Bio-Technology Co.,ltd

Tel: 027-027-16602739303 16602739303
Email: 673003916@qq.com
Country: China
ProdList: 2961
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12007
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: +86-18521732826
Email: market@aladdin-e.com
Country: China
ProdList: 48467
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9180
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32715
Advantage: 60

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

Tel: +86-18341751992 +86-15382112998
Email: 757984502@qq.com
Country: China
ProdList: 892
Advantage: 58

Wuhan Topule Biopharmaceutical Co., Ltd

Tel: +8618327326525
Email: masar@topule.com
Country: China
ProdList: 8474
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

358721-70-7, UBCS039Related Search:

UBCS039

Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)-

4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

Autophagy,UBCS039,UBCS 039,inhibit,Sirtuin,Inhibitor,UBCS-039

358721-70-7