SIS17
- Product Name
- SIS17
- CAS No.
- 2374313-54-7
- Chemical Name
- SIS17
- Synonyms
- SIS17;SIS17 - Bio-X ?;N'-Hexadecylthiophene-2-carbohydrazide;2-Thiophenecarboxylic acid, 2-hexadecylhydrazide;Histone deacetylases,SIS17,SIS-17,inhibit,HDAC,Inhibitor,SIS 17
- CBNumber
- CB95476779
- Molecular Formula
- C21H38N2OS
- Formula Weight
- 366.6
- MOL File
- 2374313-54-7.mol
SIS17 Property
- Boiling point:
- 454.9±27.0 °C(Predicted)
- Density
- 0.975±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO:99.0(Max Conc. mg/mL);270.04(Max Conc. mM)
Ethanol:18.0(Max Conc. mg/mL);49.1(Max Conc. mM) - pka
- 12.38±0.23(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- 1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24)
- InChIKey
- HSHXDCVZWHOWCS-UHFFFAOYSA-N
- SMILES
- [s]1c(ccc1)C(=O)NNCCCCCCCCCCCCCCCC
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0102230
- Product name
- SIS17
- Purity
- 98.82%
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-0102230
- Product name
- SIS17
- Purity
- 98.82%
- Packaging
- 10mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- CS-0102230
- Product name
- SIS17
- Purity
- 98.82%
- Packaging
- 50mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- CS-0102230
- Product name
- SIS17
- Purity
- 98.82%
- Packaging
- 100mg
- Price
- $690
- Updated
- 2021/12/16
- Product number
- A1166937
- Product name
- N'-Hexadecylthiophene-2-carbohydrazide
- Purity
- 98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2021/12/16
SIS17 Chemical Properties,Usage,Production
Uses
SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. SIS17 inhibits the demyristoylation of serine hydroxymethyltransferase 2, a substrate of HDAC 11, but does not inhibit other HDACs[1].
Biological Activity
SIS17 is a potent and selective HDAC11 inhibitor (IC50 = 830 nM; IC50 >100 μM against HDAC1/4/8 or SIRT1/2/3/6) th at effectively upregulates HDAC11 substrate, serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level in MCF7 cells (12.5 μM).
IC 50
HDAC11: 0.83 μM (IC50)
References
[1] Son SI, et al. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397. DOI:10.1021/acschembio.9b00292
[2] Li R, et al. A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 2022 Jul;36(7):e22326. DOI:10.1096/fj.202101742RR
SIS17 Preparation Products And Raw materials
Raw materials
Preparation Products
SIS17 Suppliers
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