SIS17 Property

Boiling point:

454.9±27.0 °C(Predicted)

Density 

0.975±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

solubility 

DMSO:99.0(Max Conc. mg/mL);270.04(Max Conc. mM)
Ethanol:18.0(Max Conc. mg/mL);49.1(Max Conc. mM)

pka

12.38±0.23(Predicted)

form 

Solid

color 

White to off-white

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

SIS17 Chemical Properties,Usage,Production

Biological Activity

SIS17 is a potent and selective HDAC11 inhibitor (IC50 = 830 nM; IC50 >100 μM against HDAC1/4/8 or SIRT1/2/3/6) th at effectively upregulates HDAC11 substrate, serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level in MCF7 cells (12.5 μM).