ChemicalBook > CAS DataBase List > TH 257

TH 257

Product Name
TH 257
CAS No.
2244678-29-1
Chemical Name
TH 257
Synonyms
TH 257;TH-257, 10 mM in DMSO;N-Benzyl-N-butyl-4-(N-phenylsulfamoyl)benzamide;LIM Kinase (LIMK),LIMKs,Inhibitor,TH-257,inhibit,TH257;Benzamide, N-butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)-
CBNumber
CB95476799
Molecular Formula
C24H26N2O3S
Formula Weight
422.54
MOL File
2244678-29-1.mol
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TH 257 Property

storage temp. 
2-8°C
solubility 
DMSO:42.25(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:42.25(Max Conc. mg/mL);100.0(Max Conc. mM)
form 
powder
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0087663
Product name
TH-257
Purity
98.91%
Packaging
10mg
Price
$113
Updated
2021/12/16
Axon Medchem
Product number
Axon2973
Product name
TH257
Purity
99%
Packaging
50mg
Price
$368.5
Updated
2021/12/16
ChemScene
Product number
CS-0087663
Product name
TH-257
Purity
98.91%
Packaging
5mg
Price
$73
Updated
2021/12/16
Ambeed
Product number
A1193405
Product name
N-Benzyl-N-butyl-4-(N-phenylsulfamoyl)benzamide
Purity
98+%
Packaging
5mg
Price
$93
Updated
2021/12/16
CSNpharm
Product number
CSN24750
Product name
TH257
Packaging
1mg
Price
$27
Updated
2021/12/16
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TH 257 Chemical Properties,Usage,Production

Biological Activity

TH-257 is a potent, type III allosteric LIM-kinase (LIMK1 & LIMK2) inhibitor (LIMK1/2 IC50 in nM = 48/29 by cell-free kinase assay and 250/150 by live cell NanoBRET assay using respective transfectants) th at targets LIMK1/2 DFG-out conformation in a non-ATP-competitive manner and exhibits no significant off-target activity by KINOMEscan assay at 1 μM. TH-263 is a structure analog and the recommended negative control for TH-257. For characterization details of TH-257, please visit the TH-257 probe summary on the Structural Genomics Consortium (SGC) website.

TH-263 is the negative control for the active probe, TH-257. TH-263 is available from Sigma. To learn more about and purchase TH-263, click here.

To learn about other SGC chemical probes, visit sigma.com/sgc

storage

Store at +4°C

TH 257 Preparation Products And Raw materials

Raw materials

Preparation Products

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TH 257 Suppliers

China 41 United States 6 Global 47
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2244678-29-1, TH 257Related Search:


  • TH 257
  • Benzamide, N-butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)-
  • LIM Kinase (LIMK),LIMKs,Inhibitor,TH-257,inhibit,TH257
  • N-Benzyl-N-butyl-4-(N-phenylsulfamoyl)benzamide
  • TH-257, 10 mM in DMSO
  • 2244678-29-1