AT-007

Product Name: AT-007
CAS No.: 2170729-29-8
Chemical Name: AT-007
Synonyms: AT-007;Govorestat;Govorestat (AT-007);AT-007, 10 mM in DMSO;AT-007,inhibit,AT 007,Aldose Reductase,AT007,Inhibitor;Thieno[3,4-d]pyridazine-1-acetic acid, 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-;2-(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3H,4H-thieno[3,4-d]pyridazin-1-yl)acetic acid;2-(4-Oxo-3-((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid
CBNumber: CB95495006
Molecular Formula: C17H10F3N3O3S2
Formula Weight: 425.4
MOL File: 2170729-29-8.mol

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AT-007 Property

Boiling point:: 610.3±65.0 °C(Predicted)
Density: 1.72±0.1 g/cm3(Predicted)
pka: 3.34±0.10(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C17H10F3N3O3S2/c18-17(19,20)8-1-2-13-12(3-8)21-14(28-13)5-23-16(26)10-7-27-6-9(10)11(22-23)4-15(24)25/h1-3,6-7H,4-5H2,(H,24,25)
InChIKey: ORQGHAJIWGGFJK-UHFFFAOYSA-N
SMILES: C1(CC(O)=O)=NN(CC2=NC3=CC(C(F)(F)F)=CC=C3S2)C(=O)C2=CSC=C12

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0106794
Product name: AT-007
Purity: 99.33%
Packaging: 50mg
Price: $825
Updated: 2021/12/16

ChemScene

Product number: CS-0106794
Product name: AT-007
Purity: 99.33%
Packaging: 100mg
Price: $1125
Updated: 2021/12/16

ChemScene

Product number: CS-0106794
Product name: AT-007
Purity: 99.33%
Packaging: 5mg
Price: $175
Updated: 2021/12/16

ChemScene

Product number: CS-0106794
Product name: AT-007
Purity: 99.33%
Packaging: 10mg
Price: $275
Updated: 2021/12/16

DC Chemicals

Product number: 013303
Product name: AT-007
Packaging: 001
Price: $700
Updated: 2021/12/16

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AT-007 Chemical Properties,Usage,Production

Uses

Govorestat (AT-007) is an orally active brain-penetrant aldose reductase inhibitor with an IC50 value of 100 pM. Govorestat has the potential for galactose-1-phosphate uridyl transferase deficiency research[1].

in vivo

Govorestat (AT-007) feeding in Sord-deficient Drosophila mitigated synaptic degeneration and significantly improves synaptic transduction, locomotor activity, and mitochondrial function. Moreover, Govorestat treatment significantly reduces ROS accumulation in Drosophila CNS^[1].

References

[1] Yi Zhu, et al. Sorbitol reduction via govorestat ameliorates synaptic dysfunction and neurodegeneration in sorbitol dehydrogenase deficiency. JCI Insight. 2023 May 22;8(10):e164954. DOI:10.1172/jci.insight.164954

AT-007 Preparation Products And Raw materials

Raw materials

Preparation Products

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AT-007 Suppliers

China 51 United States 3 Global 54

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengdrug@163.com; 18616377689
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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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Email: sales@sun-shinechem.com
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Shanghai Lollane Biological Technology Co.,Ltd.

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Fax: +86-21-52996696
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Shanghai Chaolan Chemical Technology Center

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Fan De(Beijing) Biotechnology Co., Ltd.

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Guangzhou Belka Biological Technology Co., Ltd.

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2170729-29-8, AT-007Related Search:

AT-007

Thieno[3,4-d]pyridazine-1-acetic acid, 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-

2-(4-Oxo-3-((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid

AT-007,inhibit,AT 007,Aldose Reductase,AT007,Inhibitor

Govorestat

2-(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3H,4H-thieno[3,4-d]pyridazin-1-yl)acetic acid

Govorestat (AT-007)

AT-007, 10 mM in DMSO

2170729-29-8

C17H10F3N3O3S2