1-Hexanol, 2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methyl-, (2R)-

Product Name: 1-Hexanol, 2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methyl-, (2R)-
CAS No.: 2004677-13-6
Chemical Name: 1-Hexanol, 2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methyl-, (2R)-
Synonyms: GS-9688;Selgantolimod;(R)-2-((2-Amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol;(2S)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methylhexan-1-ol;1-Hexanol, 2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methyl-, (2R)-
CBNumber: CB95514473
Molecular Formula: C14H20FN5O
Formula Weight: 293.34
MOL File: 2004677-13-6.mol

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1-Hexanol, 2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methyl-, (2R)- Property

Boiling point:: 535.1±60.0 °C(Predicted)
Density: 1.299±0.06 g/cm3(Predicted)
pka: 14.86±0.10(Predicted)
form: Solid
color: Light yellow to yellow
InChI: InChI=1S/C14H20FN5O/c1-3-4-5-14(2,8-21)20-12-11-10(18-13(16)19-12)6-9(15)7-17-11/h6-7,21H,3-5,8H2,1-2H3,(H3,16,18,19,20)/t14-/m1/s1
InChIKey: HTCJUBZBSJQWBW-CQSZACIVSA-N
SMILES: C(O)[C@@](NC1N=C(N)N=C2C=C(F)C=NC2=1)(C)CCCC

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0086927
Product name: Selgantolimod
Purity: 99.17%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0086927
Product name: Selgantolimod
Purity: 99.17%
Packaging: 10mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0086927
Product name: Selgantolimod
Purity: 99.17%
Packaging: 50mg
Price: $2800
Updated: 2021/12/16

ChemScene

Product number: CS-0086927
Product name: Selgantolimod
Purity: 99.17%
Packaging: 100mg
Price: $4100
Updated: 2021/12/16

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1-Hexanol, 2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methyl-, (2R)- Chemical Properties,Usage,Production

Uses

Selgantolimod (GS-9688) is an orally active, potent and selective toll-like receptor 8 (TLR8) agonist for the treatment of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infection[1][2][3].

in vivo

Once-weekly dosing of oral Selgantolimod induces dose-dependent increases in serum IL-12 and IL-1 receptor antagonist (IL-1RA) in cynomolgus monkeys, and leads to functional cure in the woodchuck model of chronic HBV^[1].

IC 50

TLR8; HBV

References

[1] Jules Levin. Efficacy and Safety of Oral TLR8 Agonist Selgantolimod in Virally Suppressed Adult Patients With Chronic Hepatitis B: a Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study. 2019 Nov 8-12.
[2] Benjamin Ryan. Selgantolimod Shows Promise as Treatment for Hepatitis B. November 18, 2019.
[3] Romas Geleziunas, et al. Modulators of toll-like receptors for the treatment of hiv. US20170071944A1.

1-Hexanol, 2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methyl-, (2R)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Hexanol, 2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methyl-, (2R)- Suppliers

China 26 United States 2 Global 28

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2004677-13-6, 1-Hexanol, 2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methyl-, (2R)-Related Search:

1-Hexanol, 2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methyl-, (2R)-

Selgantolimod

GS-9688

(2S)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methylhexan-1-ol

(R)-2-((2-Amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol

2004677-13-6

C14H20FN5O