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JAK1-IN-7

Product Name
JAK1-IN-7
CAS No.
2241039-81-4
Chemical Name
JAK1-IN-7
Synonyms
AZD4604;JAK1-IN-7;Londamocitinib;AZD4604， JAK1-IN-7;JAK1IN7,JAK-1-IN-7,JAK1 IN 7;Londamocitinib, 10 mM in DMSO;Londamocitinib/AZD4604/JAK1-IN-7;(R)-N-(3-(5-Fluoro-2-((2-fluoro-3-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)-1H-indol-7-yl)-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide;1-Piperazineacetamide, N-[3-[5-fluoro-2-[[2-fluoro-3-(methylsulfonyl)phenyl]amino]-4-pyrimidinyl]-1H-indol-7-yl]-α-(methoxymethyl)-4-methyl-, (αR)-
CBNumber
CB95540373
Molecular Formula
C28H31F2N7O4S
Formula Weight
599.66
MOL File
2241039-81-4.mol
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JAK1-IN-7 Property

Density 
1.411±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
13.90±0.30(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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JAK1-IN-7 Chemical Properties,Usage,Production

Uses

Londamocitinib (AZD4604) is a potent and selective JAK1 inhibitor with IC50 at 0.54 nM. Londamocitinib has anti-inflammatory activity[1][2][3].

in vivo

Londamocitinib (1 mg/kg, intravenous injection, single dose) can reduce the phosphorylation of STAT3 and STAT5 in the lung of obumin-induced asthmatic rats, inhibit pulmonary eosinophilia, and reduce advanced asthma response in the same model[3].

Animal Model:OVA-Induced Rat Model of Asthma[3]
Dosage:1 mg/kg
Administration:i.v.
Result:Reduced the proportion of phosphorylated STAT3-positive cell nuclei.

IC 50

JAK1: 0.54 nM (IC50)

References

[1] NILSSON, Karl, Magnus, et al. Jak1 selective inhibitors. WO2018134213A1.
[2] Nilsson M, et al. Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization. J Med Chem. 2023 Oct 12;66(19):13400-13415. DOI:10.1021/acs.jmedchem.3c00554
[3] Nilsson M, et al. Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma. Drug Des Devel Ther. 2022 Aug 31;16:2901-2917. DOI:10.2147/DDDT.S354291

JAK1-IN-7 Preparation Products And Raw materials

Raw materials

Preparation Products

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JAK1-IN-7 Suppliers

China 30 United States 2 Global 32
ChemCell Biomedicine Co.,Ltd.
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020-13556033878 2965585218 13556033878
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0086-0757-85406358
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chemcell@hotmail.com
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China
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185
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sales-cpd@caerulumpharma.com
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China
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Tianjin Being Technology Co., Ltd.
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18622939839
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QQ:343281693
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tjby921@163.com
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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Changzhou Yongfeng Biomedicine Co. Ltd.
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15006117673
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2973592490@.com
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2973592490@qq.com
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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Chengdu Peter-like Biotechnology Co., Ltd.
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Shanghai Star Pharmaceutical Chemical Technology Co., Ltd.
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021-58521787 17701827760
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Chunchuang (Wuhan) Technology Co., Ltd
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15727060112
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2241039-81-4, JAK1-IN-7Related Search:


  • JAK1-IN-7
  • AZD4604
  • JAK1IN7,JAK-1-IN-7,JAK1 IN 7
  • 1-Piperazineacetamide, N-[3-[5-fluoro-2-[[2-fluoro-3-(methylsulfonyl)phenyl]amino]-4-pyrimidinyl]-1H-indol-7-yl]-α-(methoxymethyl)-4-methyl-, (αR)-
  • AZD4604， JAK1-IN-7
  • Londamocitinib/AZD4604/JAK1-IN-7
  • Londamocitinib
  • (R)-N-(3-(5-Fluoro-2-((2-fluoro-3-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)-1H-indol-7-yl)-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide
  • Londamocitinib, 10 mM in DMSO
  • 2241039-81-4