ChemicalBook > CAS DataBase List > ASLAN003

ASLAN003

Product Name: ASLAN003
CAS No.: 1035688-66-4
Chemical Name: ASLAN003
Synonyms: ASLAN003;Farudodstat;Farudodstat, 10 mM in DMSO;2-[(3,5-Difluoro-3’-methoxy-4-biphenylyl)amino]nicotinic Acid;2-((3,5-difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid;2-((3,5-Difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid;2-[2,6-difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 2-[(3,5-difluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]-;2-((3,5-Difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid , Farudodstat;AML,RPL6,synthesis,Farudodstat,OPP,ASLAN 003,acute,protein,orally,EIF4B,myeloid,caspase-3,DHODH,caspase-7,THP-1,AP-1,caspase-8,MOLM-14,Apoptosis,inhibit,KG-1,leukemia,Inhibitor,ASLAN-003,Dihydroorotate Dehydrogenase,DNA/RNA Synthesis
CBNumber: CB95540737
Molecular Formula: C19H14F2N2O3
Formula Weight: 356.32
MOL File: 1035688-66-4.mol

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ASLAN003 Property

Boiling point:: 458.1±45.0 °C(Predicted)
Density: 1.376±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:77.0(Max Conc. mg/mL);216.09(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.34(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);84.19(Max Conc. mM)
DMSO:77.0(Max Conc. mg/mL);216.09(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.34(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);84.19(Max Conc. mM)
form: A crystalline solid
pka: 2.84±0.29(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0104387
Product name: ASLAN003
Purity: 99.95%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

AK Scientific

Product number: 2423DC
Product name: Aslan003
Packaging: 1g
Price: $1275
Updated: 2021/12/16

ChemScene

Product number: CS-0104387
Product name: ASLAN003
Purity: 99.95%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

DC Chemicals

Product number: 020563
Product name: Aslan003
Packaging: 003
Price: $1900
Updated: 2021/12/16

DC Chemicals

Product number: 020563
Product name: Aslan003
Packaging: 001
Price: $600
Updated: 2021/12/16

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ASLAN003 Chemical Properties,Usage,Production

Uses

Farudodstat (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. Farudodstat inhibits protein synthesis via activation of AP-1 transcription factors. Farudodstat induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice[1][2].

in vivo

Farudodstat (50 mg/kg; oral gavage; once daily; from the day 3 to 30) substantially reduces the number of disseminated tumors and prolongs survival^[1].

Animal Model:	Female NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ, NGS mice (4-6 weeks old) with MOLM-14 cells^[1]
Dosage:	50 mg/kg
Administration:	Oral gavage; once daily; from the day 3 to 30
Result:	Substantially reduced the number of disseminated tumors and the size of these tumors. Survival was significantly prolonged.

References

[1] Jianbiao Zhou, et al. ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia. Haematologica. 2019 Nov7;haematol.2019.230482.
[2] Marco L. Lolli, et al. Human Dihydroorotate Dehydrogenase (hDHODH) as a new target on Acute Myelogenous Leukemia (AML): Targeting Myeloid Differentiation using Potent and Innovative hDHODH Inhibitors. 23rd Swedish Conference on Macromolecular Structure and Function T?llberg, 14-17 June 2019

ASLAN003 Preparation Products And Raw materials

Raw materials

Preparation Products

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1035688-66-4, ASLAN003Related Search:

ASLAN003

2-[(3,5-Difluoro-3’-methoxy-4-biphenylyl)amino]nicotinic Acid

3-Pyridinecarboxylic acid, 2-[(3,5-difluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]-

Farudodstat

AML,RPL6,synthesis,Farudodstat,OPP,ASLAN 003,acute,protein,orally,EIF4B,myeloid,caspase-3,DHODH,caspase-7,THP-1,AP-1,caspase-8,MOLM-14,Apoptosis,inhibit,KG-1,leukemia,Inhibitor,ASLAN-003,Dihydroorotate Dehydrogenase,DNA/RNA Synthesis

2-[2,6-difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid

2-((3,5-Difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid

Farudodstat, 10 mM in DMSO

2-((3,5-difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid

2-((3,5-Difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid , Farudodstat

1035688-66-4