ChemicalBook > CAS DataBase List > Fluorofenidone

Fluorofenidone

Product Name: Fluorofenidone
CAS No.: 848353-85-5
Chemical Name: Fluorofenidone
Synonyms: AKF-PD;Fluorofenidone;Fluorofenidone-d3;Fluorofenidone (AKF-PD;Fluorofenidone, 10 mM in DMSO;Fluorofenidone,inhibit,Inhibitor;1-(3-fluorophenyl)-5-methylpyridin-2-one;Silane,(chloromethoxy)tris(6-methylethyl)-;1-(3-Fluorophenyl)-5-methylpyridin-2(1H)-one;2(1H)-Pyridinone, 1-(3-fluorophenyl)-5-methyl-
CBNumber: CB95582384
Molecular Formula: C12H10FNO
Formula Weight: 203.21
MOL File: 848353-85-5.mol

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Fluorofenidone Property

storage temp.: Store at -20°C
solubility: DMSO: 140 mg/mL (688.94 mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed

Product number: A1207399
Product name: 1-(3-Fluorophenyl)-5-methylpyridin-2(1H)-one
Purity: 98%
Packaging: 5mg
Price: $68
Updated: 2021/12/16

Ambeed

Product number: A1207399
Product name: 1-(3-Fluorophenyl)-5-methylpyridin-2(1H)-one
Purity: 98%
Packaging: 10mg
Price: $112
Updated: 2021/12/16

Ambeed

Product number: A1207399
Product name: 1-(3-Fluorophenyl)-5-methylpyridin-2(1H)-one
Purity: 98%
Packaging: 25mg
Price: $167
Updated: 2021/12/16

Ambeed

Product number: A1207399
Product name: 1-(3-Fluorophenyl)-5-methylpyridin-2(1H)-one
Purity: 98%
Packaging: 50mg
Price: $217
Updated: 2021/12/16

Ambeed

Product number: A1207399
Product name: 1-(3-Fluorophenyl)-5-methylpyridin-2(1H)-one
Purity: 98%
Packaging: 100mg
Price: $372
Updated: 2021/12/16

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Fluorofenidone Chemical Properties,Usage,Production

Uses

Fluorofenidone-d3 is deuterium labeled Fluorofenidone. Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Qin J, et al. Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Nephrology (Carlton). 2013 Oct;18(10):690-9. DOI:10.1111/nep.12128
[3] Lou Q, et al. Design, synthesis and antifibrotic activities of carbohydrate-modified 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones. Molecules. 2012 Jan 17;17(1):884-96. DOI:10.3390/molecules17010884

Fluorofenidone Preparation Products And Raw materials

Raw materials

Preparation Products

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848353-85-5, FluorofenidoneRelated Search:

Fluorofenidone

AKF-PD

Fluorofenidone-d3

2(1H)-Pyridinone, 1-(3-fluorophenyl)-5-methyl-

1-(3-Fluorophenyl)-5-methylpyridin-2(1H)-one

Fluorofenidone (AKF-PD

Silane,(chloromethoxy)tris(6-methylethyl)-

Fluorofenidone,inhibit,Inhibitor

1-(3-fluorophenyl)-5-methylpyridin-2-one

Fluorofenidone, 10 mM in DMSO

848353-85-5

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