DS-1001b Chemical Structure

Product Name: DS-1001b Chemical Structure
CAS No.: 1898207-64-1
Chemical Name: DS-1001b Chemical Structure
Synonyms: DS-1001b;DS-1001b (DS 1001);DS-1001b, 10 mM in DMSO;DS-1001b Chemical Structure;inhibit,DS 1001b,Inhibitor,Isocitrate Dehydrogenase (IDH),DS-1001b,DS1001b;2-Methylpropan-2-amine (E)-3-(1-(5-(2-fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)isoxazole-4-carbonyl)-3-methyl-1H-indol-4-yl)acrylate;2-Propenoic acid,3-[1-[[5-(1-fluoro-1-methylethyl)-3-(2,4,6-trichlorophenyl)-4-isoxazolyl]carbonyl]-3-methyl-1H-indol-4-yl]-,compd.with 2-methyl-2-propanamine(1:1),(2E)-
CBNumber: CB95814975
Molecular Formula: C29H29Cl3FN3O4
Formula Weight: 608.92
MOL File: 1898207-64-1.mol

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DS-1001b Chemical Structure Property

storage temp.: Store at -20°C
solubility: DMSO:14.0(Max Conc. mg/mL);22.99(Max Conc. mM)
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals

Product number: 012628
Product name: DS-1001b
Packaging: 001
Price: $750
Updated: 2021/12/16

DC Chemicals

Product number: 012628
Product name: DS-1001b
Packaging: 002
Price: $1300
Updated: 2021/12/16

DC Chemicals

Product number: 012628
Product name: DS-1001b
Packaging: 003
Price: $2700
Updated: 2021/12/16

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DS-1001b Chemical Structure Chemical Properties,Usage,Production

Uses

DS-1001b is an orally active, blood-brain permeable, potent IDH-1 (isocitrate dehydrogenase-1) mutant inhibitor. DS-1001b has antitumor activity[1][2][3].

in vivo

DS-1001b (continuous feeding of DS-1001b mixed sterile pellet food from 3 weeks after transplantation) can damage the growth of subcutaneous tumor in JJ012 xenografted mice^[2].

References

[1] Zhao Yizhaiteng, et al. Isoxazole derivative as mutated isocitrate dehydrogenase 1 inhibitor. WO2016052697A1.
[2] Nakagawa M, et al. Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma. Oncogene. 2019 Oct;38(42):6835-6849. DOI:10.1038/s41388-019-0929-9
[3] Matsunaga H, et al. Characterization of a novel BBB-permeable mutant IDH1 inhibitor, DS-1001b. Annals of Oncology, 2019, 30: v145-v146.

DS-1001b Chemical Structure Preparation Products And Raw materials

Raw materials

Preparation Products

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DS-1001b Chemical Structure Suppliers

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1898207-64-1, DS-1001b Chemical StructureRelated Search:

DS-1001b

DS-1001b Chemical Structure

2-Propenoic acid,3-[1-[[5-(1-fluoro-1-methylethyl)-3-(2,4,6-trichlorophenyl)-4-isoxazolyl]carbonyl]-3-methyl-1H-indol-4-yl]-,compd.with 2-methyl-2-propanamine(1:1),(2E)-

inhibit,DS 1001b,Inhibitor,Isocitrate Dehydrogenase (IDH),DS-1001b,DS1001b

2-Methylpropan-2-amine (E)-3-(1-(5-(2-fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)isoxazole-4-carbonyl)-3-methyl-1H-indol-4-yl)acrylate

DS-1001b (DS 1001)

DS-1001b, 10 mM in DMSO

1898207-64-1