TPN171

Product Name: TPN171
CAS No.: 1229018-87-4
Chemical Name: TPN171
Synonyms: TPN171;TPN-171,TPN171;TPN171, 10 mM in DMSO;1-Piperazineacetamide, N-[3-(4,5-diethyl-1,6-dihydro-6-oxo-2-pyrimidinyl)-4-propoxyphenyl]-4-methyl-;N-(3-(4,5-diethyl-6-0x0-1,6-dihydropyrimidin-2-yl)-4-ethoxyphenyl)-2-(4-methylpiperazin-1-yl)acetamide hydrochloride
CBNumber: CB95821472
Molecular Formula: C24H35N5O3
Formula Weight: 441.57
MOL File: 1229018-87-4.mol

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TPN171 Property

Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 8.78±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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TPN171 Chemical Properties,Usage,Production

Description

TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6. TPN171 is a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. TPN171 was proven to exert a longer lasting effect than sildenafil in animal models, providing a foundation for a once-daily oral administration for its clinical use.

Uses

TPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH)[1].

IC 50

PDE5: 0.62 nM (IC₅₀)

References

[1] Wang Z, et al. Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. J Med Chem. 2019 May 23;62(10):4979-4990. DOI:10.1021/acs.jmedchem.9b00123

TPN171 Preparation Products And Raw materials

Raw materials

Preparation Products

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TPN171 Suppliers

China 36 United States 2 Global 38

SHENZHEN REISCH BIOTECH CO., LTD

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Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghai Haozhixiang Biotechnology Co., Ltd

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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai Rechem science Co., Ltd.

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Shanghai SuperLan Chemcial Technique Centre

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ShangHai ChuanQian Chemcial Technique Centre

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Chunchuang (Wuhan) Technology Co., Ltd

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Nantong Hi-Future Biotechnology Co., Ltd

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View Lastest Price from TPN171 manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: TPN171 1229018-87-4
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

1229018-87-4, TPN171Related Search:

TPN171

TPN-171,TPN171

1-Piperazineacetamide, N-[3-(4,5-diethyl-1,6-dihydro-6-oxo-2-pyrimidinyl)-4-propoxyphenyl]-4-methyl-

TPN171, 10 mM in DMSO

N-(3-(4,5-diethyl-6-0x0-1,6-dihydropyrimidin-2-yl)-4-ethoxyphenyl)-2-(4-methylpiperazin-1-yl)acetamide hydrochloride

1229018-87-4