suvn-911

Product Name: suvn-911
CAS No.: 2414674-71-6
Chemical Name: suvn-911
Synonyms: suvn-911;HE3QJ0Mmva;SUVN-911(compound 9h);SUVN-911 Hydrochloride;suvn-911, 10 mM in DMSO;nicotinic,antidepressant,nAChR,acetylcholine,neuronal,Inhibitor,SUVN-911,suvn911,suvn 911,depression,inhibit,Nicotinic acetylcholine receptors
CBNumber: CB95855121
Molecular Formula: C11H14Cl2N2O
Formula Weight: 261.15
MOL File: 2414674-71-6.mol

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suvn-911 Property

form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0119902
Product name: SUVN-911
Purity: 99.67%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0119902
Product name: SUVN-911
Purity: 99.67%
Packaging: 10mg
Price: $580
Updated: 2021/12/16

ChemScene

Product number: CS-0119902
Product name: SUVN-911
Purity: 99.67%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0119902
Product name: SUVN-911
Purity: 99.67%
Packaging: 100mg
Price: $2550
Updated: 2021/12/16

DC Chemicals

Product number: 013319
Product name: SUVN-911(compound9h)
Packaging: 003
Price: $2800
Updated: 2021/12/16

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suvn-911 Chemical Properties,Usage,Production

Uses

SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity[1].

in vivo

SUVN-911 is devoid of cardiovascular and gastrointestinal side effects^[1].
SUVN-911 (1.0-10.0 mg/kg; p.o.; daily; for 3 days) shows significant antidepressant effects^[1].
SUVN-911 shows metabolic stability in rats^[1].
SUVN-911 (3 mg/kg; p.o.) has shown high oral exposures, longer half-lives and adequate brain penetration in Wistar rats^[1].

Animal Model:	Male Wistar rats (180-230 g)^[1]
Dosage:	1 mg/kg, 3 mg/kg, 10.0 mg/kg
Administration:	Oral administration, daily, for 3 days
Result:	Showed antidepressant like activity with no signs of tachyphylaxis.

Animal Model:	Male Wistar rats (225 ± 25 g)^[1]
Dosage:	3 mg/kg (Pharmacokinetic Analysis)
Administration:	Oral administration
Result:	AUC=3507 ng*h/mL, T_1/2=3.34 hours.

References

[1] Ramakrishna Nirogi, et al. Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression. J Med Chem. 2020 Mar 26;63(6):2833-2853. DOI:10.1021/acs.jmedchem.9b00790

suvn-911 Preparation Products And Raw materials

Raw materials

Preparation Products

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suvn-911 Suppliers

China 29 United States 3 Global 32

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2414674-71-6, suvn-911Related Search:

suvn-911

SUVN-911(compound 9h)

nicotinic,antidepressant,nAChR,acetylcholine,neuronal,Inhibitor,SUVN-911,suvn911,suvn 911,depression,inhibit,Nicotinic acetylcholine receptors

HE3QJ0Mmva

suvn-911, 10 mM in DMSO

SUVN-911 Hydrochloride

2414674-71-6