C2

Product Name: C2
CAS No.: 2244579-87-9
Chemical Name: C2
Synonyms: Ec2la;CB2R PAM;CB2R PAM,CB-2R PAM;N-[5-bromo-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxopyridin-3-yl]cycloheptanecarboxamide;N-{5-bromo-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxo-1,2-dihydropyridin-3-yl}cycloheptanecarboxamide;Cycloheptanecarboxamide, N-[5-bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]-
CBNumber: CB95984142
Molecular Formula: C21H24BrFN2O2
Formula Weight: 435.33
MOL File: 2244579-87-9.mol

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C2 Property

Boiling point:: 572.4±50.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 12.01±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 6832
Product name: Ec2la
Purity: ≥98%(HPLC)
Packaging: 10
Price: $239
Updated: 2021/12/16

Tocris

Product number: 6832
Product name: Ec2la
Purity: ≥98%(HPLC)
Packaging: 50
Price: $1004
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BC168017
Product name: C2 NEW
Packaging: 10mg
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BC168017
Product name: C2 NEW
Packaging: 50mg
Price: $450
Updated: 2021/12/16

AK Scientific

Product number: 0875EN
Product name: N-[5-Bromo-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxopyridin-3-yl]cycloheptanecarboxamide
Packaging: 50mg
Price: $657
Updated: 2021/12/16

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C2 Chemical Properties,Usage,Production

Uses

CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain[1].

in vivo

CB2R PAM (1-20 mg/kg; p.o.) displays antinociceptive activity^[1].

Animal Model:	Male CD-1 albino mice (Oxaliplatin-induced neuropathic pain model)^[1]
Dosage:	1, 5, 10, 20 mg/kg
Administration:	P.o.
Result:	Significantly increased licking latency in the animals starting from 5 mg/kg.

IC 50

cannabinoid type-2 receptors

storage

Store at -20°C

References

[1] Gado F, et al. Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief. J Med Chem. 2019;62(1):276-287. DOI:10.1021/acs.jmedchem.8b00368

C2 Preparation Products And Raw materials

Raw materials

Preparation Products

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C2 Suppliers

China 29 United States 3 Global 32

Shanghai Lollane Biological Technology Co.,Ltd.

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BOC Sciences

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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai SuperLan Chemcial Technique Centre

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Shanghai Hongye Biotechnology Co. Ltd

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TargetMol Chemicals Inc.

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Changzhou Chenhong Biotechnology Co., Ltd.

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Jinan Jiuli Biotechnology Co. , Ltd.

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2244579-87-9, C2Related Search:

Ec2la

Cycloheptanecarboxamide, N-[5-bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]-

CB2R PAM

CB2R PAM,CB-2R PAM

N-[5-bromo-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxopyridin-3-yl]cycloheptanecarboxamide

N-{5-bromo-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxo-1,2-dihydropyridin-3-yl}cycloheptanecarboxamide

2244579-87-9

C21H24BrFN2O2