(S)-6-[3-(4-Boc-1-piperazinyl)propoxy]-N-[2-(2-cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide

Product Name: (S)-6-[3-(4-Boc-1-piperazinyl)propoxy]-N-[2-(2-cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide
CAS No.: 2374782-82-6
Chemical Name: (S)-6-[3-(4-Boc-1-piperazinyl)propoxy]-N-[2-(2-cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide
Synonyms: 3BP-3580;FAP-IN-2-Boc;(S)-6-[3-(4-Boc-1-piperazinyl)propoxy]-N-[2-(2-cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide;FAPI- 14 ,(S)-6-[3-(4-Boc- 1-piperazinyl)propoxy]-N-[2-(2- cyano-4,4-difluoro- 1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide;tert-Butyl (S)-4-(3-((4-((2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)oxy)propyl)piperazine-1-carboxylate;tert-butyl 4-(3-{[4-({2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-y l]-2-oxoethyl}carbamoyl)quinolin-6-yl]oxy}propyl) piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]oxy]propyl]-, 1,1-dimethylethyl ester
CBNumber: CB96222869
Molecular Formula: C29H36F2N6O5
Formula Weight: 586.63
MOL File: 2374782-82-6.mol

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(S)-6-[3-(4-Boc-1-piperazinyl)propoxy]-N-[2-(2-cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide Property

Boiling point:: 819.2±65.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
pka: 12.05±0.46(Predicted)
form: Solid
color: White to off-white
InChIKey: QTIJFSYOOZNQMO-FQEVSTJZSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN(CCCOC2=CC=C3C(=C2)C(C(NCC(N2CC(F)(F)C[C@H]2C#N)=O)=O)=CC=N3)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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(S)-6-[3-(4-Boc-1-piperazinyl)propoxy]-N-[2-(2-cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide Chemical Properties,Usage,Production

Uses

3BP-3580 is a fibroblast activation protein (FAP) inhibitor (pIC50: 8.6), and can be used for cancer research[1].

References

[1] Frank Osterkamp, et al. Fibroblast activation protein inhibitors and use thereof. Patent. WO2023002045

(S)-6-[3-(4-Boc-1-piperazinyl)propoxy]-N-[2-(2-cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-6-[3-(4-Boc-1-piperazinyl)propoxy]-N-[2-(2-cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide Suppliers

China 35 United States 1 Global 36

Combio (Suzhou) Ltd.

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Hangzhou Beiputai Biopharmaceutical Co., Ltd

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MO-CHEM

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Accela ChemBio Co.,Ltd.

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Shanghai Chaolan Chemical Technology Center

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Xi'an Confluore Biological Technology Co., Ltd.

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Hangzhou Peptidego Biotech Co.,Ltd.

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Accela ChemBio Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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View Lastest Price from (S)-6-[3-(4-Boc-1-piperazinyl)propoxy]-N-[2-(2-cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Fmoc-FAPI-4 2374782-82-6
Price: US $0.00/mg
Min. Order: 25mg
Purity: >95.00%
Supply Ability: 25mg
Release date: 2024-04-01

2374782-82-6, (S)-6-[3-(4-Boc-1-piperazinyl)propoxy]-N-[2-(2-cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamideRelated Search:

(S)-6-[3-(4-Boc-1-piperazinyl)propoxy]-N-[2-(2-cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide

tert-butyl 4-(3-{[4-({2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-y l]-2-oxoethyl}carbamoyl)quinolin-6-yl]oxy}propyl) piperazine-1-carboxylate

1-Piperazinecarboxylic acid, 4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]oxy]propyl]-, 1,1-dimethylethyl ester

FAPI- 14 ,(S)-6-[3-(4-Boc- 1-piperazinyl)propoxy]-N-[2-(2- cyano-4,4-difluoro- 1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide

tert-Butyl (S)-4-(3-((4-((2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)oxy)propyl)piperazine-1-carboxylate

3BP-3580

FAP-IN-2-Boc

2374782-82-6