(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE
- Product Name
- (AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE
- CAS No.
- 169675-09-6
- Chemical Name
- (AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE
- Synonyms
- RO 60-0175 FUMARATE;Ro 600175 fumarate,Ro 60 0175 fumarate;(S)-1-(6-Chloro-5-fluoro-1H-indol-1-yl)propan-2-amine fumarate;(αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanaminefumarate;(S)-2-(Chloro-5-fluoro-indol-L-yl)-1-methylethylamine fumarate;(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE;(alpha-S)-6-Chloro-5-fluoro-alpha-methyl-(1H)-indole-1-ethaneaminefumarate;1H-Indole-1-ethanaMine, 6-chloro-5-fluoro-a-Methyl-, (aS)-, (2E)-2-butenedioate;1H-Indole-1-ethanamine, 6-chloro-5-fluoro-alpha-methyl-, (S)-, (E)-2-butenedioate (1:1);1H-Indole-1-ethanamine, 6-chloro-5-fluoro-alpha-methyl-, (alphas)-, (2E)-2-butenedioate (1:1)
- CBNumber
- CB9664058
- Molecular Formula
- C15H16ClFN2O4
- Formula Weight
- 342.75
- MOL File
- 169675-09-6.mol
(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE Property
- storage temp.
- Desiccate at RT
- solubility
- Soluble to 5 mM in water and to 20 mM in DMSO
- form
- Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 29520
- Product name
- Ro 60-0175
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29520
- Product name
- Ro 60-0175
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 29520
- Product name
- Ro 60-0175
- Packaging
- 10mg
- Price
- $138
- Updated
- 2021/12/16
- Product number
- 1854
- Product name
- Ro60-0175fumarate
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $159
- Updated
- 2021/12/16
- Product number
- 1854
- Product name
- Ro60-0175fumarate
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $658
- Updated
- 2021/12/16
(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE Chemical Properties,Usage,Production
Description
Ro 60-0175 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2 that stimulates increases in intracellular calcium levels in CHO-K1 cells expressing human 5-HT2A, 5-HT2B, and 5-HT2C receptors (EC50s = 447, 0.9, and 32 nM, respectively). It is selective for human 5-HT2A and 5-HT2C (Kis = 32 and 1 nM, respectively) over human 5-HT1A, 5-HT1D, 5-HT6, and 5-HT7, rat 5-HT1B and 5-HT3, and guinea pig 5-HT4 receptors (Kis = ≥1,995 nM), as well as adenosine A1 and A2, histamine H1-3, dopamine D1-5, α1-, α2-, and β1-adrenergic, M1-5 muscarinic, nicotinic, kainate, AMPA, and μ-, δ-, and κ-opioid receptors (IC50s = >1,000 nM), but does bind to β2-adrenergic receptors (IC50 = 251 nM). In vivo, Ro 60-0175 increases plasma levels of corticosterone, oxytocin, and prolactin in rats (ED50s = 2.43, 4.19, and 4.03 mg/kg, respectively), effects that are not inhibited by the 5-HT2C antagonist SB-242084 or the 5-HT2A antagonist MDL 100,907 (volinanserin; ).
Uses
Ro 60-0175 fumarate is a potent and selective SR-2 agonist.
Biological Activity
Potent, selective 5-HT 2 receptor agonist; shows selectivity for the 5-HT 2C subtype (pK i values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT 2C , 2A , 1A , 6 and 7 receptors respectively). Centrally active following oral or systemic administration in vivo .
storage
Desiccate at RT