ChemicalBook > CAS DataBase List > 1-Methyl-1H-pyrazole-5-boronic acid pinacol ester

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester

Product Name
1-Methyl-1H-pyrazole-5-boronic acid pinacol ester
CAS No.
847818-74-0
Chemical Name
1-Methyl-1H-pyrazole-5-boronic acid pinacol ester
Synonyms
1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-Methyl-5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;CBI-BB ZERO/005567;e-5-boronic Acid PinacoL;1-Methyl-1H-pyrazole-5-bo...;Pinacol 1-methyl-1h-pyrazole-5-borate;Pinacol 1-methyl-pyrazol-5-yl-boronate;1-Methyl-1H-pyrazole-5-boronic acid pinacol;1-Methyl-pyrazole-5-boronic acid pinacol ester
CBNumber
CB9668122
Molecular Formula
C10H17BN2O2
Formula Weight
208.07
MOL File
847818-74-0.mol
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1-Methyl-1H-pyrazole-5-boronic acid pinacol ester Property

Melting point:
67-71 °C
Boiling point:
308.3±15.0 °C(Predicted)
Density 
1.05±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
pka
1.94±0.10(Predicted)
form 
crystal
color 
white
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-7-12-13(8)5/h6-7H,1-5H3
InChIKey
HLXOVAMYQUFLPE-UHFFFAOYSA-N
SMILES
N1(C)C(B2OC(C)(C)C(C)(C)O2)=CC=N1
CAS DataBase Reference
847818-74-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
TSCA 
No
HazardClass 
IRRITANT
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
698628
Product name
1-Methyl-1H-pyrazole-5-boronic acid pinacol ester
Purity
97%
Packaging
5g
Price
$63.2
Updated
2025/07/31
Sigma-Aldrich
Product number
698628
Product name
1-Methyl-1H-pyrazole-5-boronic acid pinacol ester
Purity
97%
Packaging
1g
Price
$26
Updated
2023/06/20
TCI Chemical
Product number
M2681
Product name
1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$67
Updated
2025/07/31
TCI Chemical
Product number
M2681
Product name
1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$266
Updated
2023/06/20
TRC
Product number
M330343
Product name
1-Methyl-1H-pyrazole-5-boronic acid pinacol ester
Packaging
10mg
Price
$45
Updated
2021/12/16
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1-Methyl-1H-pyrazole-5-boronic acid pinacol ester Chemical Properties,Usage,Production

Chemical Properties

White to light brown solid

Uses

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester is used as a pharmaceutical intermediate, agrochemical intermediate.

Synthesis

930-36-9

61676-62-8

847818-74-0

To a solution of 1-methylpyrazole (4.1 g, 50 mmol) in tetrahydrofuran (THF, 100 mL) was slowly added n-butyllithium (n-BuLi, 2.2 M solution in THF, 55 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 1 hour and then cooled to -78 °C. Subsequently, 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (12.3 mL, 60 mmol) was added to the reaction system. The reaction was carried out at -78 °C for 15 min and then gradually warmed up to 0 °C, taking 1 hour. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride (NH4Cl) solution and extracted with dichloromethane (DCM). The organic phases were combined, washed with distilled water (2 × 100 mL), dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to afford the brown solid product 1-methyl-1H-pyrazole-5-boronic acid pinacol ester (8.0 g, 77% yield), which could be used for the subsequent reaction without further purification. The product was detected by liquid chromatography-mass spectrometry (LCMS, ES), showing m/z 127 (M+H)+ [RB(OH)2]; nuclear magnetic resonance hydrogen spectroscopy (1H NMR, CDCl3, 400 MHz) showed δ 7.57 (s, 1H), 6.75 (s, 1H), 4.16 (s, 3H) and 1.41 (s, 12H).

References

[1] Patent: WO2009/158372, 2009, A1. Location in patent: Page/Page column 30; 31
[2] Patent: WO2009/158374, 2009, A2. Location in patent: Page/Page column 30
[3] Patent: WO2008/98105, 2008, A1. Location in patent: Page/Page column 36
[4] Patent: US2010/216843, 2010, A1. Location in patent: Page/Page column 20-21
[5] Patent: WO2008/121786, 2008, A1. Location in patent: Page/Page column 42-43

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Trimethyl borate Pinacol Hexane Nitrogen Toluene Tetrahydrofuran Diethyl ether 5A molecular sieve Triisopropyl borate 1-Methylpyrazole n-Butyllithium

Preparation Products

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View Lastest Price from 1-Methyl-1H-pyrazole-5-boronic acid pinacol ester manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
1-Methyl-1H-pyrazole-5-boronicacidpinacolester 847818-74-0
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-07-05
Jinan Finer Chemical Co., Ltd
Product
1-Methyl-1H-pyrazole-5-boronic acid pinacol ester 847818-74-0
Price
US $23.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20mt
Release date
2023-08-17
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-Methyl-1H-pyrazole-5-boronic acid pinacol ester 847818-74-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

847818-74-0, 1-Methyl-1H-pyrazole-5-boronic acid pinacol esterRelated Search:

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  • e-5-boronic Acid PinacoL
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  • 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 2-(1-Methyl-1H-pyrazol-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole &gt
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  • 847818-74-0
  • Boronic ester
  • Organoborons
  • Pyrazole