2,6-DIFLUORO-4-METHOXYBENZOIC ACID
- Product Name
- 2,6-DIFLUORO-4-METHOXYBENZOIC ACID
- CAS No.
- 123843-65-2
- Chemical Name
- 2,6-DIFLUORO-4-METHOXYBENZOIC ACID
- Synonyms
- RARECHEM AL BO 2258;2,6-DIFLUORO-4-METHOXYBENZOIC ACID;Benzoic acid, 2,6-difluoro-4-methoxy-;2,6-Difluoro-4-methoxybenzoic acid 97%;2,6-Difluoro-4-methoxybenzoic acid 95+%;2,6-DIFLUORO-4-METHOXYBENZOIC ACID, 98% MIN.;4-Carboxy-3,5-difluoroanisole, 2,6-Difluoro-p-anisic acid
- CBNumber
- CB9674051
- Molecular Formula
- C8H6F2O3
- Formula Weight
- 188.13
- MOL File
- 123843-65-2.mol
2,6-DIFLUORO-4-METHOXYBENZOIC ACID Property
- Melting point:
- 184-185°C
- Boiling point:
- 232.0±35.0 °C(Predicted)
- Density
- 1.399±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder
- pka
- 2.61±0.10(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 123843-65-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-R36/37/38
- Safety Statements
- 26-36/37/39-36/37-S36/37-S26
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 700053
- Product name
- 2,6-Difluoro-4-methoxybenzoic acid
- Purity
- 97%
- Packaging
- 1G
- Price
- $71.4
- Updated
- 2022/05/15
- Product number
- D451883
- Product name
- 2,6-Difluoro-4-methoxybenzoicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 008924
- Product name
- 2,6-Difluoro-4-methoxybenzoic acid
- Purity
- 98%
- Packaging
- 500mg
- Price
- $17
- Updated
- 2021/12/16
- Product number
- 2621-3-58
- Product name
- 2,6-Difluoro-4-methoxybenzoic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 008924
- Product name
- 2,6-Difluoro-4-methoxybenzoic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
2,6-DIFLUORO-4-METHOXYBENZOIC ACID Chemical Properties,Usage,Production
Synthesis
124-38-9
93343-10-3
123843-65-2
A hexane solution (31.2 mL) of 1.6 M n-butyllithium was slowly added dropwise to a tetrahydrofuran (120 mL) solution of 1,3-difluoro-5-methoxybenzene (5.54 g) at -78 °C under nitrogen protection. The reaction temperature of -78 °C was maintained and stirring was continued for 30 min. Subsequently, sublimated dry ice (8.46 g) was added to the reaction system through a silica gel tube and the reaction was continued at -78 °C. The reaction mixture was gradually warmed to room temperature and stirred for 5 min. After completion of the reaction, the reaction solution was acidified by slowly adding 1 N hydrochloric acid solution to the reaction solution at 0 °C. The reaction mixture was extracted with mixed ethyl acetate/tetrahydrofuran solvent and the organic phases were combined. The organic phase was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the resulting solid was washed with hexane and diisopropyl ether to give 2,6-difluoro-4-methoxybenzoic acid (5.00 g) as a white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 3.83 (3H, s), 6.82 (2H, d, J = 11.0 Hz), 13.43 (1H, brs).
References
[1] Heterocycles, 2006, vol. 67, # 2, p. 489 - 494
[2] Tetrahedron Letters, 2004, vol. 45, # 1, p. 95 - 98
[3] Patent: US2016/115128, 2016, A1. Location in patent: Paragraph 1337; 1338
2,6-DIFLUORO-4-METHOXYBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-DIFLUORO-4-METHOXYBENZOIC ACID manufacturers
- Product
- 2,6-Difluoro-4-Methoxybenzoic Acid 123843-65-2
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09