3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE

Product Name: 3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE
CAS No.: 567-01-1
Chemical Name: 3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE
Synonyms: 3β,5α-THDOC;5α-PREGNAN-3β, 21-DIOL-20-ONE;5-A-pregnane-3-B-21-diol-20-one;3β,5α-Tetrahydrodeoxycorticosterone;"3β,5a-Tetrahydrodeoxycorticosterone";5-ALPHA-PREGNAN-3-BETA, 21-DIOL-20-ONE;3-beta,5-alfa-Tetrahydrodeoxycorticosterone;3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE;1-[(1S,3aS,3bR,5aS,7S,9aS,9bS,11aS)-7-hydroxy-9 a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]p henanthren-1-yl]-2-hydroxyethan-1-one
CBNumber: CB9676121
Molecular Formula: C21H34O3
Formula Weight: 334.49
MOL File: 567-01-1.mol

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3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE Property

storage temp.: Store at -20°C
solubility: ≤25mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
form: crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18431
Product name: Epiallopregnanolone
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18431
Product name: Epiallopregnanolone
Purity: ≥95%
Packaging: 5mg
Price: $70
Updated: 2024/03/01

Cayman Chemical

Product number: 18431
Product name: Epiallopregnanolone
Purity: ≥95%
Packaging: 10mg
Price: $122
Updated: 2024/03/01

Cayman Chemical

Product number: 18431
Product name: Epiallopregnanolone
Purity: ≥95%
Packaging: 25mg
Price: $267
Updated: 2024/03/01

TRC

Product number: T293290
Product name: 3β,5α-Tetrahydrodeoxycorticosterone
Packaging: 5mg
Price: $55
Updated: 2021/12/16

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3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE Chemical Properties,Usage,Production

Description

3β,5α-THDOC is a neurosteroid. It inhibits seizures induced by pilocarpine, but not pentylenetetrazol (PTZ; ), in mice (ED₅₀s = 45.9 and >100 mg/kg, respectively). 3β,5α-THDOC has been found in the urine of women during the third trimester of pregnancy.

Uses

3β,5α-Tetrahydrodeoxycorticosterone is a novel derivative of the steroid Dehydroepiandrosterone (DHEA), a known uncompetitive inhibitor of Glucose 6-Phosphate Dehydrogenase (G6PD). Studies have shown that 3β,5α-Tetrahydrodeoxycorticosterone may have potential function in the modulation of calcium and GABAA-gated chloride channel currents found in rat and guinea-pig neurons.

in vitro

epiallopregnanolone showed no effects on the gaba-mediated chloride flux through several types of recombinant gaba receptors. epiallopregnanolone inhibited the allopregnanolone-stimulated gaba-mediated chloride flux through gabaa receptors. epiallopregnanolone antagonized the inhibitory effects of allopregnanolone and ethanol on the population spike in the ca1 region of the hippocampal brain slices [1]. epiallopregnanolone selectively blocked the allopregnanolone inhibition of the population spike in the rat hippocampal ca1[3].

in vivo

in rats trained to discriminate either 0.8g/kg or 1.2 g/kg ethanol, 100 mg/kg epiallopregnanolone treatment decreased the maximum effect by 40% and 54% ethanol lever, respectively. epiallopregnanolone significantly decreased response rates when compared with control condition [1].

References

[1] ginsburg b c, lamb r j. alphaxalone and epiallopregnanolone in rats trained to discriminate ethanol[j]. alcoholism: clinical and experimental research, 2005, 29(9): 1621-1629.
[2] macdonald r l, olsen r w. gabaa receptor channels[j]. annual review of neuroscience, 1994, 17(1): 569-602.
[3] wang m, bckstrm t, landgren s. epiallopregnanolone selectively blocks the allopregnanolone inhibition of the population spike in the rat hippocampal ca1[j]. acta physiologica scandinavica, 1999, 167(2): a5-a5.

3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE Suppliers

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567-01-1, 3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONERelated Search:

3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE

5-A-pregnane-3-B-21-diol-20-one

5-ALPHA-PREGNAN-3-BETA, 21-DIOL-20-ONE

3-beta,5-alfa-Tetrahydrodeoxycorticosterone

3β,5α-Tetrahydrodeoxycorticosterone

1-[(1S,3aS,3bR,5aS,7S,9aS,9bS,11aS)-7-hydroxy-9 a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]p henanthren-1-yl]-2-hydroxyethan-1-one

"3β,5a-Tetrahydrodeoxycorticosterone"

3β,5α-THDOC

5α-PREGNAN-3β, 21-DIOL-20-ONE

567-01-1