4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID

Product Name: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID
CAS No.: 313339-35-4
Chemical Name: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID
Synonyms: RARECHEM AL BO 1988;4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxylicaci;4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID;4,6-dichloro-2-(Methylthio)-5-pyriMidine carboxylic acid;5-Pyrimidinecarboxylic acid, 4,6-dichloro-2-(methylthio)-;4,6-dichloro-2-(Methylsulfanyl)pyriMidine-5-carboxylic acid;4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID ISO 9001：2015 REACH
CBNumber: CB9682186
Molecular Formula: C6H4Cl2N2O2S
Formula Weight: 239.08
MOL File: 313339-35-4.mol

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4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID Property

Melting point:: 159-163 °C (D)
Boiling point:: 384.5±37.0 °C(Predicted)
Density: 1.71±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 0.08±0.32(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C6H4Cl2N2O2S/c1-13-6-9-3(7)2(5(11)12)4(8)10-6/h1H3,(H,11,12)
InChIKey: LUCAXEBLTQAMHS-UHFFFAOYSA-N
SMILES: C1(SC)=NC(Cl)=C(C(O)=O)C(Cl)=N1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 718769
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $149
Updated: 2023/06/20

TRC

Product number: D438523
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD35529
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
Packaging: 5G
Price: $85
Updated: 2021/12/16

Matrix Scientific

Product number: 090233
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
Purity: 95+%
Packaging: 1g
Price: $124
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD35529
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
Packaging: 2g
Price: $50
Updated: 2021/12/16

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4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

6299-25-8

124-38-9

313339-35-4

1. 4,6-dichloro-2-methylthioalkylpyrimidine (1.00 g, 5.13 mmol) was dissolved in tetrahydrofuran (THF, 10 mL). 2. 2.0 M lithium diisopropylammonium (LDA) solution in THF (5.9 mL, 11.8 mmol) was added to the solution at -78 °C and stirred for 1 hour. 3. carbon dioxide gas (dry ice) was passed into the reaction mixture at -78 °C. 4. the reaction mixture was warmed to room temperature and stirring was continued for 1.5 hours. 5. Upon completion of the reaction, the organic layer was separated by adding 10% aqueous hydrochloric acid and ethyl acetate for extraction. 6. The organic layer was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. 7. The residue was re-slurried with hexane and the solid was collected by filtration to afford 2-(methylthio)-4,6-dichloropyrimidine-5-carboxylic acid (964 mg, 79% yield). 8. The product was passed through ESI-MSR. 8. The product was characterized by ESI-MS and 1H-NMR: ESI-MS m/z 237 [M-H]-; 1H-NMR (CDCl3) δ 2.60 (s, 3H), 9.68 (brs, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 16, p. 4642 - 4646
[2] Patent: EP2163554, 2010, A1. Location in patent: Page/Page column 49
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 5, p. 1485 - 1488
[4] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 20, p. 5717 - 5732
[5] Patent: EP1496059, 2005, A1. Location in patent: Page 19-20

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID Suppliers

China 75 Germany 1 India 1 United Kingdom 2 United States 9 Global 88

Baiyin Chengze Chemical Technology Co., Ltd.

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View Lastest Price from 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID 313339-35-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-11-24

Career Henan Chemical Co

Product: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID 313339-35-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

313339-35-4, 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACIDRelated Search:

4,6-Dichloro-2-(methylthio)pyrimidine 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 4-CHLOROPYRIMIDINE-5-CARBOXYLIC ACID 4,6-dichloropyrimidine-5-carboxylic acid 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID 4,6-Dichloro-5-pyrimidinecarbaldehyde 4-Chloro-6-methyl-2-(methylthio)pyrimidine

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID

RARECHEM AL BO 1988

4,6-dichloro-2-(Methylsulfanyl)pyriMidine-5-carboxylic acid

4,6-dichloro-2-(Methylthio)-5-pyriMidine carboxylic acid

5-Pyrimidinecarboxylic acid, 4,6-dichloro-2-(methylthio)-

4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxylicaci

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID ISO 9001：2015 REACH

313339-35-4

C6H4Cl2N2O2S

Heterocycle-Pyrimidine series

C6 to C8

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

Building Blocks