4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID

Product Name: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID
CAS No.: 313339-35-4
Chemical Name: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID
Synonyms: RARECHEM AL BO 1988;4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxylicaci;4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID;4,6-dichloro-2-(Methylthio)-5-pyriMidine carboxylic acid;5-Pyrimidinecarboxylic acid, 4,6-dichloro-2-(methylthio)-;4,6-dichloro-2-(Methylsulfanyl)pyriMidine-5-carboxylic acid;4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID ISO 9001：2015 REACH
CBNumber: CB9682186
Molecular Formula: C6H4Cl2N2O2S
Formula Weight: 239.08
MOL File: 313339-35-4.mol

More

Less

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID Property

Melting point:: 159-163 °C (D)
Boiling point:: 384.5±37.0 °C(Predicted)
Density: 1.71±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 0.08±0.32(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C6H4Cl2N2O2S/c1-13-6-9-3(7)2(5(11)12)4(8)10-6/h1H3,(H,11,12)
InChIKey: LUCAXEBLTQAMHS-UHFFFAOYSA-N
SMILES: C1(SC)=NC(Cl)=C(C(O)=O)C(Cl)=N1

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 718769
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $149
Updated: 2023/06/20

TRC

Product number: D438523
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD35529
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
Packaging: 2g
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD35529
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
Packaging: 5G
Price: $85
Updated: 2021/12/16

Matrix Scientific

Product number: 090233
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
Purity: 95+%
Packaging: 1g
Price: $124
Updated: 2021/12/16

More

Less

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

6299-25-8

124-38-9

313339-35-4

1. 4,6-dichloro-2-methylthioalkylpyrimidine (1.00 g, 5.13 mmol) was dissolved in tetrahydrofuran (THF, 10 mL). 2. 2.0 M lithium diisopropylammonium (LDA) solution in THF (5.9 mL, 11.8 mmol) was added to the solution at -78 °C and stirred for 1 hour. 3. carbon dioxide gas (dry ice) was passed into the reaction mixture at -78 °C. 4. the reaction mixture was warmed to room temperature and stirring was continued for 1.5 hours. 5. Upon completion of the reaction, the organic layer was separated by adding 10% aqueous hydrochloric acid and ethyl acetate for extraction. 6. The organic layer was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. 7. The residue was re-slurried with hexane and the solid was collected by filtration to afford 2-(methylthio)-4,6-dichloropyrimidine-5-carboxylic acid (964 mg, 79% yield). 8. The product was passed through ESI-MSR. 8. The product was characterized by ESI-MS and 1H-NMR: ESI-MS m/z 237 [M-H]-; 1H-NMR (CDCl3) δ 2.60 (s, 3H), 9.68 (brs, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 16, p. 4642 - 4646
[2] Patent: EP2163554, 2010, A1. Location in patent: Page/Page column 49
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 5, p. 1485 - 1488
[4] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 20, p. 5717 - 5732
[5] Patent: EP1496059, 2005, A1. Location in patent: Page 19-20

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID Suppliers

China 75 Germany 1 India 1 United Kingdom 2 United States 9 Global 88

Baiyin Chengze Chemical Technology Co., Ltd.

Tel: +86 943-8535351 13389336721
Fax: +86-943-8535351
Email: sales@chengzechem.com
Country: China
ProdList: 289
Advantage: 58

Beijing FaMu RuiSi Pharmaceuticals Co.,Ltd

Tel: 18901358086
Fax: 86-010-61252196
Email: pharma_reese@126.com
Country: China
ProdList: 61
Advantage: 57

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Shanghai Coupling Pharmaceutical R&D Co.,Ltd.（Former company is Brother Chemistry）

Tel: 021-50106671
Fax: 021-50106671
Country: China
ProdList: 49
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

More

Less

View Lastest Price from 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID 313339-35-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-11-24

Career Henan Chemical Co

Product: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID 313339-35-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

313339-35-4, 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACIDRelated Search:

4,6-Dichloro-2-(methylthio)pyrimidine 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 4-CHLOROPYRIMIDINE-5-CARBOXYLIC ACID 4,6-dichloropyrimidine-5-carboxylic acid 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID 4,6-Dichloro-5-pyrimidinecarbaldehyde 4-Chloro-6-methyl-2-(methylthio)pyrimidine

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID

RARECHEM AL BO 1988

4,6-dichloro-2-(Methylsulfanyl)pyriMidine-5-carboxylic acid

4,6-dichloro-2-(Methylthio)-5-pyriMidine carboxylic acid

5-Pyrimidinecarboxylic acid, 4,6-dichloro-2-(methylthio)-

4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxylicaci

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID ISO 9001：2015 REACH

313339-35-4

C6H4Cl2N2O2S

Heterocycle-Pyrimidine series

C6 to C8

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

Building Blocks