Methyl (R)-(-)-3-hydroxybutyrate
- Product Name
- Methyl (R)-(-)-3-hydroxybutyrate
- CAS No.
- 3976-69-0
- Chemical Name
- Methyl (R)-(-)-3-hydroxybutyrate
- Synonyms
- METHYL 3-HYDROXYBUTANOATE;Methyl-3-hydroxybutyrate;Methyl (R)-(-)-3-hyd;R-hydroxy butyl etherate;methyl R-3-hydroxybutanoate;METHYL (R)-3-HYDROXYBUTYRATE;METHYL 3-(R)-HYDROXYBUTYRATE;Methyl (3R)-hydroxybutanoate;METHYL D-(R)-3-HYDROXYBUTYRATE;Methyl (R)-(-)-3-hydroxybutyra
- CBNumber
- CB9682595
- Molecular Formula
- C5H10O3
- Formula Weight
- 118.13
- MOL File
- 3976-69-0.mol
Methyl (R)-(-)-3-hydroxybutyrate Property
- alpha
- -21.5 º (neat)
- Boiling point:
- 56-58 °C/11 mmHg (lit.)
- Density
- 1.055 g/mL at 20 °C (lit.)
- refractive index
- n20/D 1.421(lit.)
- Flash point:
- 161 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Oil
- pka
- 13.95±0.20(Predicted)
- color
- Colourless
- optical activity
- [α]20/D 19.5°, neat
- Water Solubility
- Slightly soluble in water.
- BRN
- 3648161
- InChI
- InChI=1S/C5H10O3/c1-4(6)3-5(7)8-2/h4,6H,3H2,1-2H3/t4-/m1/s1
- InChIKey
- LDLDJEAVRNAEBW-SCSAIBSYSA-N
- SMILES
- C(OC)(=O)C[C@H](O)C
- LogP
- -0.412 (est)
- CAS DataBase Reference
- 3976-69-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37-24/25-23
- RIDADR
- NA 1993 / PGIII
- WGK Germany
- 3
- HS Code
- 29181990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 243159
- Product name
- Methyl (R)-3-hydroxybutyrate
- Purity
- 99%
- Packaging
- 1g
- Price
- $101
- Updated
- 2024/03/01
- Product number
- H0705
- Product name
- Methyl (R)-(-)-3-Hydroxybutyrate
- Purity
- >98.0%(GC)
- Packaging
- 10mL
- Price
- $31
- Updated
- 2023/06/20
- Product number
- H0705
- Product name
- Methyl (R)-(-)-3-Hydroxybutyrate
- Purity
- >98.0%(GC)
- Packaging
- 25mL
- Price
- $60
- Updated
- 2023/06/20
- Product number
- L14151
- Product name
- Methyl (R)-(-)-3-hydroxybutyrate, 98%
- Packaging
- 1g
- Price
- $34.65
- Updated
- 2024/03/01
- Product number
- L14151
- Product name
- Methyl (R)-(-)-3-hydroxybutyrate, 98%
- Packaging
- 5g
- Price
- $95.65
- Updated
- 2024/03/01
Methyl (R)-(-)-3-hydroxybutyrate Chemical Properties,Usage,Production
Chemical Properties
clear colorless liquid
Uses
Methyl (R)-3-hydroxybutyrate may be used in the preparation of (R)-(-)-3-hydroxybutanoic acid and poly-(R)-(-)-3-hydroxybutyrate.
General Description
Methyl (R)-(-)-3-hydroxybutyrate is a monocarboxylic acid that is metabolized by phosphofructokinase and other enzymes to produce the corresponding 3-hydroxybutyrate. This compound is synthesized from tiglic acid, which can be obtained from corynebacterium. The production of it can be optimized by using a biotransformation process.
Synthesis
In the glove box, put RuCl3 (0.69mg, 0.0033mmol), (R)-BINAP (2.3mg, 0.0036mmol), (1R,2R)-1,2-diphenyl-1,2-ethylenediamine (0.78 mg, 0.0036mmol) and isopropanol (150g) were added to a single-necked flask equipped with a magnetic stirrer, the stirring was turned on, the metal precursor and the ligand were dissolved and coordinated for 30 minutes,Obtain the catalyst solution, seal the single-neck bottle, take it out of the glove box, and pump it into a 0.5L reactor with a flat flow pump under the protection of nitrogen. The reactor has been replaced with nitrogen in advance, and the substrate methyl acetoacetate (116g, 1mol) and Potassium tert-butoxide (0.12g).After the catalyst solution was added, the reactor was replaced with hydrogen for three times, 8MPa hydrogen was charged, and the reactor was turned on for stirring and heating.When the internal temperature of the reactor reaches 100°C, open the hydrogen gas inlet valve, keep the internal pressure of the reactor at 10MPa, start timing, keep the reaction for 5 hours, the flowmeter shows that the hydrogen absorption rate is less than 0.1mL/min, terminate the reaction, and cool the reactor To room temperature, sampling and GC analysis showed that the conversion rate of raw material methyl acetoacetate was 99.9%, and the selectivity of (R)-1,3-butanediol was 8.8%.The ee value is 99.2%, and the selectivity of Methyl (R)-(-)-3-hydroxybutyrate is 90.9%.
Methyl (R)-(-)-3-hydroxybutyrate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl (R)-(-)-3-hydroxybutyrate Suppliers
- Tel
- +1 416 493 6870
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- +1 416 499 9759
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- Country
- Canada
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View Lastest Price from Methyl (R)-(-)-3-hydroxybutyrate manufacturers
- Product
- Methyl (R)-(-)-3-hydroxybutyrate 3976-69-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-06-27
- Product
- Methyl (R)-(-)-3-Hydroxybutyrate 3976-69-0
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2023-05-24
- Product
- Methyl (R)-(-)-3-Hydroxybutyrate 3976-69-0
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 97%
- Supply Ability
- 10 tons
- Release date
- 2023-03-23