DYNAMIN INHIBITORY PEPTIDE
- Product Name
- DYNAMIN INHIBITORY PEPTIDE
- CAS No.
- 251634-21-6
- Chemical Name
- DYNAMIN INHIBITORY PEPTIDE
- Synonyms
- P4;QVPSRPNRAP;Dynamin inhibitory p;DYNAMIN INHIBITORY PEPTIDE;L-Proline, L-glutaminyl-L-valyl-L-prolyl-L-seryl-L-arginyl-L-prolyl-L-asparaginyl-L-arginyl-L-alanyl-
- CBNumber
- CB9687611
- Molecular Formula
- C47H80N18O14
- Formula Weight
- 1121.25
- MOL File
- 251634-21-6.mol
DYNAMIN INHIBITORY PEPTIDE Property
- storage temp.
- Desiccate at -20°C
- solubility
- ≥112.1 mg/mL in DMSO; ≥23.6 mg/mL in EtOH; ≥9.4 mg/mL in H2O
- form
- solid
- color
- White to off-white
- Water Solubility
- Soluble to 1 mg/ml in water
- Sequence
- Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro
N-Bromosuccinimide Price
- Product number
- 1774
- Product name
- Dynamininhibitorypeptide
- Packaging
- 1
- Price
- $292
- Updated
- 2021/12/16
- Product number
- A1046
- Product name
- Dynamininhibitorypeptide
- Packaging
- 1mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- A1046
- Product name
- Dynamininhibitorypeptide
- Packaging
- 5mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- PEP0004472
- Product name
- DYNAMIN INHIBITORY PEPTIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.12
- Updated
- 2021/12/16
- Product number
- A1046
- Product name
- Dynamininhibitorypeptide
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
DYNAMIN INHIBITORY PEPTIDE Chemical Properties,Usage,Production
Uses
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors[1].
Biological Activity
dynamin inhibitory peptide is a peptide (gln-val-pro-ser-arg-pro-asn-arg-ala-pro) inhibitor of the gtpase dynamin.dynamin is a 100-kda large gtpase that functions to tabulate membranes and liberate nascent vesicles from the golgi apparatus and plasma membrane. dynamin also plays a role in many processes including division of organelles,cytokinesis and microbial pathogen resistance.dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. reduces gabaa receptor internalization and increases miniature ispc amplitude and frequency in neurons expressing gabaa receptors.figure1 formula of dynamin inhibitory peptide
storage
Store at -20°C
References
1. McNiven, M. A., Cao, H., Pitts, K. R. & Yoon, Y. (2000) Trends Biochem. Sci. 25, 115–120.2. Hinshaw, J. E. (2000) Annu. Rev. Cell Dev. Biol 16, 483–519.3. Thoms S, Erdmann R (Oct 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation.". FEBS J 272 (20): 5169–81.4. Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419-25.5. Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972-7. 6. Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302-7.
DYNAMIN INHIBITORY PEPTIDE Preparation Products And Raw materials
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