2-ACETYL-4-CHLOROTHIOPHENE

Product Name: 2-ACETYL-4-CHLOROTHIOPHENE
CAS No.: 34730-20-6
Chemical Name: 2-ACETYL-4-CHLOROTHIOPHENE
Synonyms: 1-(4-chlorothiophen-2-yl)ethan-1-one;Avatrombopag Impurity 26;4-chloro-2-acetothiophene;Avatroposide impurities33;2-ACETYL-4-CHLOROTHIOPHENE;2-acetyl-4-chlopothiophene;2-Acetyl-4-chlorothiophene, 98;1-(4-chlorothien-2-yl)ethanone;Ethanone, 1-(4-chloro-2-thienyl)-;1-(4-Chlorothiophen-2-yl)ethanone
CBNumber: CB9690448
Molecular Formula: C6H5ClOS
Formula Weight: 160.62
MOL File: 34730-20-6.mol

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2-ACETYL-4-CHLOROTHIOPHENE Property

Boiling point:: 263.0±25.0 °C(Predicted)
Density: 1.334
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
InChI: InChI=1S/C6H5ClOS/c1-4(8)6-2-5(7)3-9-6/h2-3H,1H3
InChIKey: FKESGQASARHBDC-UHFFFAOYSA-N
SMILES: C(=O)(C1SC=C(Cl)C=1)C

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Safety

Risk Statements: 36
Safety Statements: 26
RIDADR: UN2810
HazardClass: 6.1
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: H30384
Product name: 2-Acetyl-4-chlorothiophene, 98+%
Packaging: 5g
Price: $106.65
Updated: 2024/03/01

Alfa Aesar

Product number: H30384
Product name: 2-Acetyl-4-chlorothiophene, 98+%
Packaging: 1g
Price: $35.9
Updated: 2023/06/20

Alfa Aesar

Product number: H30384
Product name: 2-Acetyl-4-chlorothiophene, 98+%
Packaging: 25g
Price: $392.65
Updated: 2024/03/01

TRC

Product number: C611233
Product name: 1-(4-chlorothiophen-2-yl)ethanone
Packaging: 2.5g
Price: $155
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC139326
Product name: 1-(4-Chlorothiophen-2-yl)ethanone
Packaging: 10g
Price: $177
Updated: 2021/12/16

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2-ACETYL-4-CHLOROTHIOPHENE Chemical Properties,Usage,Production

Description

2-Acetyl-4-chlorothiophene is an oxychloride that belongs to the family of thiourea derivatives. It is synthesized by reacting phosphorus oxychloride with 2,3-dichloroacetophenone in a solvent such as dioxane or acetonitrile. The final product is purified by means of vacuum distillation and recrystallization from diethyl ether, hexane, and chlorinated hydrocarbons.

Reactions

Pd(OAc)2 catalysed the direct arylation of some functionalized halothiophene derivatives allowing the synthesis in only one step of polyfunctionalized arylated thiophenes. In the presence of 2-acetyl-4-chlorothiophene and various aryl bromides, the 5-arylation products were obtained in moderate to high yields employing only 0.5 mol% catalyst. Researchers studied the coupling of 2-acetyl-4-chlorothiophene with several aryl bromides employing 0.5 mol% Pd(OAc)2 as the catalyst and KOAc as the base. These phosphine-free catalyst reaction conditions allowed the successful coupling of several aryl bromides to more simple thiophene derivatives. Using such conditions, the 5-arylated thiophenes were obtained with high isolated yields. With this procedure, the priority for the arylation of this 2,4-disubstituted thiophene is the 5-position. Moreover, no formation of by-products, such as thiophene oligomers, due to the oxidative addition of this chlorothiophene to palladium was detected during these reactions[1].

References

[1] Kassem Beydoun, Henri Doucet. “Palladium-catalyzed direct 5-arylation of formyl- or acetyl-halothiophene derivatives.” Journal of Organometallic Chemistry 696 9 (2011): Pages 1749-1759.

2-ACETYL-4-CHLOROTHIOPHENE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-ACETYL-4-CHLOROTHIOPHENE Suppliers

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View Lastest Price from 2-ACETYL-4-CHLOROTHIOPHENE manufacturers

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: 2-acetyl-4-chlorothiophene 34730-20-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ＞98% by GC
Supply Ability: 50kg
Release date: 2023-01-09

Hebei Weibang Biotechnology Co., Ltd

Product: 2-ACETYL-4-CHLOROTHIOPHENE 34730-20-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-29

Suzhou Nordica Biopharma CO.,LTD

Product: 1-(4-chlorothiophen-2-yl)ethan-1-one 34730-20-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 2 tons
Release date: 2024-11-15

34730-20-6, 2-ACETYL-4-CHLOROTHIOPHENERelated Search:

2-ACETYL-3-CHLOROTHIOPHENE 3-Acetyl-5-chlorothiophene-2-sulfonyl chloride 3-Acetyl-5-chlorothiophene-2-sulfonamide 2-ACETYL-5-CHLOROTHIOPHENE 3-Acetyl-5-chlorothiophene-2-boronic acid 2-ACETYL-4,5-DICHLOROTHIOPHENE 2-ACETYL-4-CHLOROTHIOPHENE 2-CHLORO-1-(4,5-DICHLORO-2-THIENYL)ETHAN-1-ONE 1-(5-BROMO-4-CHLORO-2-THIENYL)ETHANONE CHEMBRDG-BB 6539802 3-ACETYL-5-CHLOROTHIOPHENE 2-ACETYL-4-CHLOROTHIOPHENE-DISCONTINUED AKOS 232-01 AKOS 93095 AKOS 91937 AKOS 91988 AKOS 91920 AKOS 90692

2-ACETYL-4-CHLOROTHIOPHENE

1-(4-chlorothien-2-yl)ethanone

2-Acetyl-4-chlorothiophene, 98

4-chloro-2-acetothiophene

1-(4-chlorothiophen-2-yl)ethan-1-one

1-(4-Chlorothiophen-2-yl)ethanone

Ethanone, 1-(4-chloro-2-thienyl)-

2-acetyl-4-chlopothiophene

Avatrombopag Impurity 26

2-ACETYL-4-CHLOROTHIOPHENE ISO 9001：2015 REACH

Avatroposide impurities33

1-(3,4-dichloro-6-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid

34730-20-6

Intermediate

Sulfur compounds