CONCANAMYCIN A
- Product Name
- CONCANAMYCIN A
- CAS No.
- 80890-47-7
- Chemical Name
- CONCANAMYCIN A
- Synonyms
- FOLIMYCIN;S-45A;A661-I;x4357b;NSC 674620;Canavalin A;Concanamycin;CONCANAMYCIN A;A,ConcanaMycin;Antibiotic S-45A
- CBNumber
- CB9696475
- Molecular Formula
- C46H75NO14
- Formula Weight
- 866.09
- MOL File
- 80890-47-7.mol
CONCANAMYCIN A Property
- Melting point:
- 179-180℃ (dichloromethane ethanol )
- Boiling point:
- 966.4±65.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Soluble in DMSO
- pka
- 12.46±0.70(Predicted)
- form
- Lyophilized solid
- color
- White
- BRN
- 3560277
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety
- Hazard Codes
- T+
- Risk Statements
- 26/27/28-36
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3462 6.1/PG 2
- WGK Germany
- 3
- RTECS
- CB9732000
- F
- 10-21
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 2941900000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P262Do not get in eyes, on skin, or on clothing.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C9705
- Product name
- Concanamycin A
- Purity
- ≥70% (HPLC)
- Packaging
- 25μg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- C9705
- Product name
- Concanamycin A
- Purity
- ≥70% (HPLC)
- Packaging
- 0.1mg
- Price
- $597
- Updated
- 2024/03/01
- Product number
- 27689
- Product name
- Concanamycin A
- Purity
- from Streptomyces sp., ≥80% (HPLC)
- Packaging
- 250μg
- Price
- $1410
- Updated
- 2023/06/20
- Product number
- 344085
- Product name
- Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem
- Purity
- A highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM).
- Packaging
- 10μg
- Price
- $143
- Updated
- 2022/05/15
- Product number
- 27689
- Product name
- Concanamycin A
- Purity
- from
- Packaging
- 250ug
- Price
- $1150
- Updated
- 2021/12/16
CONCANAMYCIN A Chemical Properties,Usage,Production
Description
Concanamycin A (80890-47-7) is a potent and specific inhibitor of the vacuolar (V-type) H+-ATPase which can induce apoptotic cell death in various cell lines.1,2?Inhibits cell surface expression of virus envelope glycoproteins.3?Dramatically increases the rate of extracellular vesicle release from a variety of cell types.4?Inhibits autophagy by blocking lysosomal acidification.5
Uses
Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp.. It has been shown to act as a potent and specific vacuolar-ATPase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins.
Uses
Concanamycin A has been used:
- as a lysosomal inhibitor in young and old fibroblasts
- as a vacuolar-type H+-ATPase inhibitor in presynaptic vesicles
- as a lysosomal acidification blocker in HepG2 hepatocytes cells
Definition
ChEBI: A concanamycin in which the lactone ring contains 4 double bonds and is substituted by 4 methyl groups, 2 hydroxy groups, 2 methoxy groups and an ethyl group.
General Description
Chemical structure: macrolide
Biological Activity
Specific inhibitor of V-type (vacuolar) H + -ATPase that displays > 2000-fold selectivity over other H + -ATPases (IC 50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H + -ATPases and porcine P-type Na + ,K + -ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.
Biochem/physiol Actions
Concanamycin A (ConA) inhibits acidification of organelles and perforin-mediated cytotoxicity. It is a vacuolar-type v-ATPase inhibitor. ConA possesses antiprotozoal and antineoplastic properties. It mediates inhibition of the negative factor (Nef) protein of the human immunodeficiency virus.
storage
Store at -20°C
References
1) Nishihara?et al.?(1995),?Specific inhibitors if vacuolar type H(+)-ATPases induce apoptotic cell death; Biochem. Biophys, Res. Commun.,?212?255 2) Hong?et al. (2006),?Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells; J. Pharmacol. Exp. Ther.,?319?672 3) Muroi?et al.?(1993),?Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus; Cell Struct. Function,?18?139 4) Cashikar and Hanson (1987),?A cell-based assay for CD63-containing extracellular vesicles; PLoS One,?14?e0220007 5) Gradzka?et al.?(2018),?Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes; Cell Death Dis.,?9?529
CONCANAMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
CONCANAMYCIN A Suppliers
- Tel
- 025-85560043 13675144456
- Fax
- 025-85563444
- sean.lv@synzest.com
- Country
- China
- ProdList
- 11442
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 4550
- Advantage
- 62
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4654
- Advantage
- 58
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25014
- Advantage
- 65
- Tel
- +86-21-65211385-8001 36031160
- Fax
- +86-21-65211385-8004
- sales@shruji.com
- Country
- China
- ProdList
- 3224
- Advantage
- 55
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3750
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7854
- Advantage
- 58
- Tel
- 021-61119791,13386096464
- Fax
- 021-50190009
- bzswkf@foxmail.com
- Country
- China
- ProdList
- 3924
- Advantage
- 50
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51471
- Advantage
- 80
- Tel
- 4000-819-385 010-62329685 13718666987
- Fax
- 010-62340519
- Country
- China
- ProdList
- 1971
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 021-52907766-8042
- Fax
- 021-52906523
- Country
- China
- ProdList
- 9947
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27322
- Advantage
- 60
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20810
- Advantage
- 60
- Tel
- 025-57798860
- sales@njromanme.com
- Country
- China
- ProdList
- 4534
- Advantage
- 58
- Tel
- 400-1166-196 18502815961
- Fax
- QQ:800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 14623
- Advantage
- 60
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12308
- Advantage
- 58
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- 027-027-83778875 15807197853
- Fax
- 027-83991220
- 15807197853@163.com
- Country
- China
- ProdList
- 3979
- Advantage
- 58
- Tel
- 0755-0755-85201366 18938635012
- Fax
- 0755-85201366
- sales@regentsciences.com
- Country
- China
- ProdList
- 9293
- Advantage
- 58
- Tel
- 400-400-1332688 18019345275
- Fax
- 400-133-2688
- amy@rhawn.cn
- Country
- China
- ProdList
- 15503
- Advantage
- 58
- Tel
- 400-400-400-9004166 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52712
- Advantage
- 58
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6870
- Advantage
- 58
- Tel
- 13739298932
- 531626407@qq.com
- Country
- China
- ProdList
- 3010
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9730
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 28557
- Advantage
- 58
- Tel
- +86-029-89586680 +86-18192503167
- Fax
- +86-29-88380327
- 1026@dideu.com
- Country
- China
- ProdList
- 9126
- Advantage
- 58
- Tel
- 15921040873
- 1434142450@qq.com
- Country
- CHINA
- ProdList
- 7651
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58
- Tel
- +86-029-81138252 +86-18789408387
- Fax
- 029-88380327
- 1057@dideu.com
- Country
- China
- ProdList
- 3054
- Advantage
- 58
- Tel
- 029-61856359 18690052321
- Fax
- 029-88380327
- 1027@dideu.com
- Country
- China
- ProdList
- 10008
- Advantage
- 58
- Tel
- 021-57810052 18930344717
- Fax
- 021-57810052
- 2089316240@qq.com
- Country
- China
- ProdList
- 9396
- Advantage
- 58
- Tel
- 400-820-6829
- sales@mitachieve.com
- Country
- China
- ProdList
- 8864
- Advantage
- 58
- Tel
- 17269768198
- Fax
- QQ:1213744847
- prochemx@163.com
- Country
- China
- ProdList
- 613
- Advantage
- 58
- Tel
- 0571-89903882 13626641628
- jiangnan@huidabiotech.com
- Country
- China
- ProdList
- 3661
- Advantage
- 58
- Tel
- 15527250409
- Fax
- QQ:2692360204
- wenhaotian12@163.com
- Country
- China
- ProdList
- 4576
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8141
- Advantage
- 58
- Tel
- 18642120371
- 2837458851@qq.com
- Country
- China
- ProdList
- 9925
- Advantage
- 58
- Tel
- 021-50967598 02150967598
- sales@abmole.cn
- Country
- China
- ProdList
- 4495
- Advantage
- 58
- Tel
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29778
- Advantage
- 58
- Tel
- 0513-68819626; 13813788405
- Fax
- 0513-68669626
- feiyubio2@163.com
- Country
- China
- ProdList
- 4821
- Advantage
- 58
- Tel
- 18502762009
- 721846333@qq.com
- Country
- China
- ProdList
- 2446
- Advantage
- 58
- Tel
- 027-59626688 18771149750
- sales@amyjet.com
- Country
- China
- ProdList
- 3004
- Advantage
- 58
- Tel
- 0571-0571-89903882 15990081639
- sunshixuan@huidabiotech.com
- Country
- China
- ProdList
- 3705
- Advantage
- 58
- Tel
- 0731-85561020 15386497078
- yunbang@yunbangapi.com
- Country
- China
- ProdList
- 4152
- Advantage
- 58
- Tel
- 0370-2059268 15672839268
- Fax
- 03702782809
- 2352713635@qq.com
- Country
- China
- ProdList
- 4206
- Advantage
- 58
- Tel
- 400-605-7200 17312445705
- sales022@b2star.com
- Country
- China
- ProdList
- 3764
- Advantage
- 58
- Tel
- +86-027-59232304 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9892
- Advantage
- 58
View Lastest Price from CONCANAMYCIN A manufacturers
- Product
- Concanamycin A 80890-47-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-09
- Product
- CONCANAMYCIN A 80890-47-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-24