ChemicalBook > CAS DataBase List > 1-Bromo-2,4,5-trifluorobenzene

1-Bromo-2,4,5-trifluorobenzene

Product Name: 1-Bromo-2,4,5-trifluorobenzene
CAS No.: 327-52-6
Chemical Name: 1-Bromo-2,4,5-trifluorobenzene
Synonyms: 2,4,5-TRIFLUOROBROMOBENZENE;2,4,5 bromobenzene;1-Bromo-2,4,5-trifL;1-Bromo-2,4,5-triflu;2,4,5-TRIFLUOROBENZOBROMIDE;2,4,5-Trifluorophenyl bromide;2-BROMO-1,4,5-TRIFLUOROBENZENE;1-BROMO-2,4,5-TRIFLUOROBENZENE;1,2,4-Trifluoro-5-bromobenzene;5-Bromo-1,2,4-trifluorobenzene
CBNumber: CB9696743
Molecular Formula: C6H2BrF3
Formula Weight: 210.98
MOL File: 327-52-6.mol

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1-Bromo-2,4,5-trifluorobenzene Property

Melting point:: −19 °C(lit.)
Boiling point:: 144 °C(lit.)
Density: 1.802 g/mL at 25 °C(lit.)
refractive index: n20/D 1.485(lit.)
Flash point:: 132 °F
storage temp.: 2-8°C
solubility: water: insoluble
form: clear liquid
color: Colorless to Light yellow to Light orange
Specific Gravity: 1.81
Water Solubility: insoluble
BRN: 1636588
InChI: InChI=1S/C6H2BrF3/c7-3-1-5(9)6(10)2-4(3)8/h1-2H
InChIKey: DVTULTINXNWGJY-UHFFFAOYSA-N
SMILES: C1(Br)=CC(F)=C(F)C=C1F
CAS DataBase Reference: 327-52-6(CAS DataBase Reference)
NIST Chemistry Reference: Benzene, 1-bromo-2,4,5-trifluoro-(327-52-6)

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Safety

Hazard Codes: Xi,F
Risk Statements: 36/37/38-10
Safety Statements: 26-36/37/39-37/39-16
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
Hazard Note: Flammable
HazardClass: 3
PackingGroup: III
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 247979
Product name: 1-Bromo-2,4,5-trifluorobenzene
Purity: 99%
Packaging: 5g
Price: $40.37
Updated: 2025/07/31

TCI Chemical

Product number: B1167
Product name: 1-Bromo-2,4,5-trifluorobenzene
Purity: >98.0%(GC)
Packaging: 5g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: B1167
Product name: 1-Bromo-2,4,5-trifluorobenzene
Purity: >98.0%(GC)
Packaging: 25g
Price: $78
Updated: 2025/07/31

TRC

Product number: B688505
Product name: 1-Bromo-2,4,5-trifluorobenzene
Packaging: 10g
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB46132
Product name: 1-Bromo-2,4,5-trifluorobenzene
Packaging: 25g
Price: $120
Updated: 2021/12/16

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1-Bromo-2,4,5-trifluorobenzene Chemical Properties,Usage,Production

Chemical Properties

clear slightly yellow liquid

Uses

1-Bromo-2,4,5-trifluorobenzene is the intermediate of liquid crystals. The derivatives of this compound can be used as intermediates for the synthesis of qunolone antibacterial. It is employed in the synthesis of 3-ethenyl, 3-ethynyl, 3-aryl, and 3-cyclopropyl-2, 4, 5-trifluorobenzoic acids from 1-bromo-2, 4, 5-trifluorobenzene and 2, 4, 5-trifluoro-3-hydroxybenzoic acid.

Uses

Intermediates of Liquid Crystals

Definition

ChEBI: 1-Bromo-2,4,5-trifluorobenzene is an organofluorine compound.

General Description

1-Bromo-2,4,5-trifluorobenzene undergoes Br-Mg-exchange reaction with i-PrMgBr in THF to yield organomagnesium compound.

Synthesis

367-23-7

327-52-6

The general procedure for the synthesis of 2,4,5-trifluorobromobenzene from 1,2,4-trifluorobenzene was as follows: 100 g of 1,2,4-trifluorobenzene and 3 g of tin tetrachloride-polystyrene complex were added to a 500 mL three-necked flask, and glacial acetic acid was used as the reaction solvent. At room temperature, 127 mL of liquid bromine was added slowly and dropwise. The reaction lasted for 2 h, during which the progress of the reaction was monitored by thin-layer chromatography (TLC), and after confirming that the ingredients were fully reacted, vacuum evaporation was performed to remove the glacial acetic acid. Subsequently, 500 mL of chloroform was added and the organic phase was washed with 3% dilute hydrochloric acid, followed by the addition of saturated sodium sulfite solution to remove residual bromine from the organic phase. After sequential washing, the organic phase was washed with saturated saline. Finally, the solvent was removed by distillation to afford 158 g of 2,4,5-trifluorobromobenzene in 98.7% yield and 99.6% purity as shown by gas chromatography analysis.

References

[1] Patent: CN107673951, 2018, A. Location in patent: Paragraph 0015; 0016; 0017; 0018
[2] Journal of the American Chemical Society, 1951, vol. 73, p. 153
[3] Journal of the American Chemical Society, 1959, vol. 81, p. 94,98

1-Bromo-2,4,5-trifluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

2,4,5-Trifluorophenylacetic acid

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1-Bromo-2,4,5-trifluorobenzene Suppliers

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View Lastest Price from 1-Bromo-2,4,5-trifluorobenzene manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-Bromo-2,4,5-trifluorobenzene 327-52-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-20

Henan Aochuang Chemical Co.,Ltd.

Product: 1-Bromo-2,4,5-trifluorobenzene 327-52-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

Hebei Yanxi Chemical Co., Ltd.

Product: 1-Bromo-2,4,5-trifluorobenzene 327-52-6
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-10

327-52-6, 1-Bromo-2,4,5-trifluorobenzeneRelated Search:

2-BROMO-1,3,4-TRIFLUOROBENZENE,1-Bromo-2,3,6-trifluorobenzene 98%,1-Bromo-2,3,6-trifluorobenzene98% 5-BROMO-1,2,3-TRIFLUOROBENZENE,1-BROMO-3,4,5-TRIFLUOROBENZENE,1-Bromo-3,4,5-trifluorobenzene99%,1-Bromo-3,4,5-trifluorobenzene 99% 1,2,4-TRIFLUOROBENZENE OR 1-BROMO 2,4,5-TRIFLUOROBENZENE 1-Bromo-2,3,5-trifluorobenzene98%,1-Bromo-2,3,5-trifluorobenzene 98%,1-BROMO-2,3,5-TRIFLUOROBENZENE 2,3,4-Trifluorobromobenzene 1-Bromo-2,4,6-trifluorobenzene 1-BROMO-2,3,6-TRIFLUOROBENZENE

2,4,5-Trifluorobromobenzene 99%

1-BROMO-2,4,5-TRIFLUOROBENZENE

2,4,5-TRIFLUOROBENZOBROMIDE

2,4,5-TRIFLUOROBROMOBENZENE

2-BROMO-1,4,5-TRIFLUOROBENZENE

Two, four, five, three fluorine broMobenzene

2,4,5 bromobenzene

1-Bromo-2,4,5-trifluorobenzene 99%

1-Bromo-2,4,5-trifluorobenzene99%

1-BROMO-2,4,5-TRIFLUOROBENZENE 98+%

2,4,5-Trifluorophenyl bromide

1,2,4-Trifluoro-5-bromobenzene

1-Bromo-2,4,5-triflu

5-Bromo-1,2,4-trifluorobenzene

1-Bromo-2,4,5-trifluorobenzene&gt

1-Bromo-2,4,5-trifL

Benzene, 1-bromo-2,4,5-trifluoro-

1-Bromo-2,4,5-trifluorobenzene ISO 9001：2015 REACH

1-Bromo-2,4,4-trifluorobenzene

327-52-6

37-52-6

372-52-6

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