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CYCLOPENTOLATE

Product Name
CYCLOPENTOLATE
CAS No.
512-15-2
Chemical Name
CYCLOPENTOLATE
Synonyms
Cyplegin;Mydrilate;yclopentolate;CYCLOPENTOLATE;Cyclopentylate;Cyclopentoiate;DL-Cyclopentolate;β-Dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetate;2-(Dimethylamino)ethyl (1-hydroxycyclopentyl)(phenyl)acetate;beta-(Dimethylamino)ethyl (1-hydroxycyclopentyl)phenylacetate
CBNumber
CB9707085
Molecular Formula
C17H25NO3
Formula Weight
291.39
MOL File
512-15-2.mol
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CYCLOPENTOLATE Property

Boiling point:
409.7±20.0 °C(Predicted)
Density 
1.136±0.06 g/cm3(Predicted)
pka
pKa 7.93(H2O ) (Uncertain)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C986405
Product name
Cyclopentolate
Packaging
25mg
Price
$200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC61687
Product name
Cyclopentolate
Packaging
5mg
Price
$40
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC61687
Product name
Cyclopentolate
Packaging
10mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC61687
Product name
Cyclopentolate
Packaging
25mg
Price
$125
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC61687
Product name
Cyclopentolate
Packaging
50mg
Price
$200
Updated
2021/12/16
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CYCLOPENTOLATE Chemical Properties,Usage,Production

Originator

Cyclogyl,Schieffelin,US,1953

Uses

Cyclopentolate is an effective mydriatic and cycloplegic that begins to act very quickly and has a relatively short duration. It is used also in ophthalmoscopy for causing pre-operational mydriasis.

Uses

Cyclopentolate is a muscarinic antagonist. It is used in eye drops to dilate the eyes and prevent them from refocusing making the eyes more sensitive to light and may cause blurring.

Uses

thalidomide derivative for multiple myeloma and myelodysplastic syndromes

Definition

ChEBI: A carboxylic ester resulting from the formal condensation of (1-hydroxycyclopentyl)(phenyl)acetic acid with N,N-dimethylethanolamine. A tertiary amine antimuscarinic with actions similar to atropine, it is used as its ydrochloride salt to produce mydriasis (excessive dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) for opthalmic diagnostic procedures. It acts more quickly than atropine and has a shorter duration of action.

Manufacturing Process

To a well stirred suspension of 9 g of sodium phenyl acetate and 2.4 g of magnesium turnings in 25 cc of anhydrous ether, a solution of 9.4 cc of isopropyl bromide in 50 cc of anhydrous ether are added. The mixture is refluxed for one hour (during which time propane is evolved) and then 5 cc of cyclopentanone in 25 cc of anhydrous ether are added dropwise. The mixture is then refluxed for one hour and poured over ice water containing some hydrochloric acid. The ether solution is separated and extracted with 200 cc of 5% sodium hydroxide. The alkaline solution on acidification gives the free acid which is filtered off, dried in a desiccator and recrystallized from a mixture of ethylene dichloride and petroleum ether.
The product is 2-phenyl-2-(1-hydroxycyclopentyl)ethanoic acid, melting at 95° to 97°C. Of this product, 4.5 g in 30 cc of dry isopropyl alcohol are refluxed for 16 hours with 2.5 g of β-chloroethyl dimethyl amine. The solution is cooled and filtered clear from the solid by-product. The solvent is removed under reduced pressure on the steam bath and the residue is washed with anhydrous ether. It is dissolved in ethyl acetate from which it crystallizes. It is the hydrochloride of β-(dimethylamino)ethyl ester of 2-phenyl-2-(1- hydroxycyclopentyl) ethanoic acid, melting at 134° to 136°C.

brand name

Akpentolate (Akorn); Cyclogyl (Alcon); Pentolair (Bausch & Lomb); Pentolair (Pharmafair).

Therapeutic Function

Anticholinergic (ophthalmic)

Synthesis

Cyclopentolate, 2-(dimethylamino)ethylic ester of 1-hydroxycyclopentane- |á-phenylacetic acid (14.1.39), is synthesized by the esterification of |á-(1- droxycylopentyl) phenylacetic acid (14.1.38) using 2-dimethylaminoethylchloride, |á-(1- Hydroxycyclopentyl) phenylacetic acid (14.1.38) is synthesized by reacting the sodium salt of phenylacetic acid with cyclopentanone in the presence of isopropylmagnesium bromide [30].

Veterinary Drugs and Treatments

Cyclopentolate is an anticholinergic agent that induces relaxation of the sphincter of the iris and the ciliary muscles. When applied topically to the eyes, it causes a rapid, intense cycloplegic and mydriatic effect that is maximal in 15 – 60 minutes; recovery usually occurs within 24 hours. The cycloplegic and mydriatic effects are slower in onset and longer in duration in animal patients who have darkly pigmented irises. Cyclopentolate is used mainly to produce mydriasis and cycloplegia for diagnostic purposes.

CYCLOPENTOLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLOPENTOLATE Suppliers

Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Boyners Pharm-Tech Co., Ltd.
Tel
021-54581719 13817873692
Fax
021-31329586
Email
mkt@boynerspharm.com
Country
China
ProdList
1722
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15394
Advantage
58
Baoji Guokang Healthchem co.,ltd
Tel
+8615604608665 15604608665
Email
dominicguo@gk-bio.com
Country
CHINA
ProdList
9414
Advantage
58
Changzhou Kechem Bio-Scientific Co., LTD.
Tel
0519-68985668 13685222090
Fax
qq735434464
Email
sales@kechem.cn
Country
China
ProdList
26028
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Pushan Industry (Shaanxi) Co., Ltd.
Tel
029-81310890 13571859809
Email
info@pushanshiye.com
Country
China
ProdList
10007
Advantage
58
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View Lastest Price from CYCLOPENTOLATE manufacturers

Baoji Guokang Healthchem co.,ltd
Product
CYCLOPENTOLATE 512-15-2
Price
US $158.70/g
Min. Order
1g
Purity
99%
Supply Ability
500g
Release date
2021-06-04

512-15-2, CYCLOPENTOLATERelated Search:


  • CYCLOPENTOLATE
  • 1-Hydroxy-α-phenylcyclopentaneacetic acid, 2-(dimethylamino)ethyl ester
  • Benzeneacetic acid, α-(1-hydroxycyclopentyl)-, 2-(dimethylamino)ethyl ester
  • Cyclopentaneacetic acid, 1-hydroxy-α-phenyl-, 2-(dimethylamino)ethyl ester (6CI, 7CI, 8CI)
  • DL-Cyclopentolate
  • β-Dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetate
  • Cyplegin
  • α-(1-Hydroxycyclopentyl)benzeneacetic acid 2-(dimethylamino)ethyl
  • 2-(1-hydroxycyclopentyl)-2-phenyl-acetic acid 2-dimethylaminoethyl ester
  • 2-dimethylaminoethyl 2-(1-hydroxycyclopentyl)-2-phenyl-ethanoate
  • 1-Hydroxy-alpha-phenylcyclopentaneacetic acid, 2-(dimethylamino)ethyl ester
  • 2-(Dimethylamino)ethyl (1-hydroxycyclopentyl)(phenyl)acetate
  • 2-Dimethylaminoethyl 1-hydroxy-alpha-phenylcyclopentaneacetate
  • Benzeneacetic acid, alpha-(1-hydroxycyclopentyl)-, 2-(dimethylamino)ethyl ester
  • beta-(Dimethylamino)ethyl (1-hydroxycyclopentyl)phenylacetate
  • Cyclopentylate
  • Mydrilate
  • yclopentolate
  • 2-dimethylaminoethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate
  • Cyclopentoiate
  • Benzeneacetic acid, a-(1-hydroxycyclopentyl)-, 2-(dimethylamino)ethylester
  • 512-15-2