3-(2H-TETRAZOL-5-YL)-PYRIDINE
- Product Name
- 3-(2H-TETRAZOL-5-YL)-PYRIDINE
- CAS No.
- 3250-74-6
- Chemical Name
- 3-(2H-TETRAZOL-5-YL)-PYRIDINE
- Synonyms
- DK7403;Lu 31-102;AKOS B020828;BUTTPARK 14\02-73;CBI-BB ZERO/005386;IFLAB-BB F2124-0755;ART-CHEM-BB B020828;5-β-Pyridyltetrazole;SPECS AO-289/25117008;5-(3-PYRIDYL)TETRAZOLE
- CBNumber
- CB9709382
- Molecular Formula
- C6H5N5
- Formula Weight
- 147.14
- MOL File
- 3250-74-6.mol
3-(2H-TETRAZOL-5-YL)-PYRIDINE Property
- Melting point:
- 240 °C
- Boiling point:
- 379.4±44.0 °C(Predicted)
- Density
- 1.388±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 5.99±0.12(Predicted)
- Appearance
- White to off-white Solid
- Water Solubility
- Soluble in water (slightly).
- InChI
- InChI=1S/C6H5N5/c1-2-5(4-7-3-1)6-8-10-11-9-6/h1-4H,(H,8,9,10,11)
- InChIKey
- SECHDFHDDVELCV-UHFFFAOYSA-N
- SMILES
- C1=NC=CC=C1C1=NNN=N1
- CAS DataBase Reference
- 3250-74-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38-22
- Safety Statements
- 26-36/37/39-36
- WGK Germany
- 3
- HazardClass
- IRRITANT-HARMFUL
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T310693
- Product name
- 3-(2H-Tetrazol-5-yl)pyridine
- Packaging
- 2.5g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 003161
- Product name
- 5-(3-Pyridyl)-1H-tetrazole
- Purity
- 98%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- X6712
- Product name
- 3-(1H-tetrazol-5-yl)pyridine
- Packaging
- 1g
- Price
- $132
- Updated
- 2021/12/16
- Product number
- 003161
- Product name
- 5-(3-Pyridyl)-1H-tetrazole
- Purity
- 98%
- Packaging
- 5g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- X6712
- Product name
- 3-(1H-tetrazol-5-yl)pyridine
- Packaging
- 5g
- Price
- $450
- Updated
- 2021/12/16
3-(2H-TETRAZOL-5-YL)-PYRIDINE Chemical Properties,Usage,Production
Uses
5-(3-Pyridyl)-1H-tetrazole is used as a pharmaceutical intermediate. The Pyridine,3-(2H-tetrazol-5-yl)- acts as reactant with 1-(4-bromo-phenyl)-3-piperidino-propan-1-one, hydrochloride, and obtain the 1-(4-bromo-phenyl)-3-(5-pyridin-3-yl-tetrazol-2-yl)-propan-1-one. This reaction needs the solvent of dimethylformamide. The yield is 31%. In addition, this reaction should be taken for 8 hours at the temperature of 150°C.
Synthesis
100-54-9
3250-74-6
The general procedure for the synthesis of 5-(3-pyridinyl)-1H-tetrazole from 3-cyanopyridine was as follows: 3-cyanopyridine (2 mmol), sodium azide (2.4 mmol, 1.2 eq.), and tetrabutylammonium bromide (2.4 mmol, 1.2 eq.) were added to a vial with a screw cap. The reaction mixture was stirred at 105 °C and the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature and dissolved in deionized water (5 mL). Subsequently, the aqueous solution was acidified with 1 M hydrochloric acid to pH = 3. If precipitate formation was observed, the suspension was filtered and the filter cake was washed with deionized water to obtain a pure product. If no precipitate formation was observed, the aqueous solution was extracted with ethyl acetate (3 x 4 mL). The organic phases were combined, washed with 1 M hydrochloric acid (3 x 4 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the pure product.
References
[1] Journal of Heterocyclic Chemistry, 2010, vol. 47, # 4, p. 913 - 922
[2] Polyhedron, 2011, vol. 30, # 15, p. 2606 - 2610
[3] Mendeleev Communications, 2011, vol. 21, # 6, p. 334 - 336
[4] European Journal of Organic Chemistry, 2014, vol. 2014, # 2, p. 436 - 441
[5] European Journal of Organic Chemistry, 2014, vol. 2014, # 2, p. 436 - 441
3-(2H-TETRAZOL-5-YL)-PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(2H-TETRAZOL-5-YL)-PYRIDINE manufacturers
- Product
- 3-(2H-TETRAZOL-5-YL)-PYRIDINE 3250-74-6
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-11