MMP INHIBITOR II
- Product Name
- MMP INHIBITOR II
- CAS No.
- 203915-59-7
- Chemical Name
- MMP INHIBITOR II
- Synonyms
- MMP INHIBITOR II;N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-1,3-diazinane-2-carboxamide;N-HYDROXY-1,3-DI-(4-METHOXYBENZENESULPHONYL)-5,5-DIMETHYL-[1,3]-PIPERAZINE-2-CARBOXAMIDE;2-Pyrimidinecarboxamide, hexahydro-N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-
- CBNumber
- CB9726695
- Molecular Formula
- C21H27N3O8S2
- Formula Weight
- 513.58
- MOL File
- Mol file
MMP INHIBITOR II Property
- Density
- 1.385±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 9.53±0.23(Predicted)
N-Bromosuccinimide Price
- Product number
- 444247
- Product name
- MMP Inhibitor II - CAS 203915-59-7 - Calbiochem
- Purity
- The MMP Inhibitor II, also referenced under CAS 203915-59-7, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
- Packaging
- 1MG
- Price
- $187
- Updated
- 2024/03/01
- Product number
- J65638
- Product name
- MMP Inhibitor II
- Packaging
- 5mg
- Price
- $126
- Updated
- 2021/12/16
- Product number
- J65638
- Product name
- MMP Inhibitor II
- Packaging
- 10mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- 15958
- Product name
- MMP Inhibitor II
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 15958
- Product name
- MMP Inhibitor II
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $169
- Updated
- 2024/03/01
MMP INHIBITOR II Chemical Properties,Usage,Production
Uses
A potent, reversible, broad range inhibitor of matrix metalloproteinases
Biological Activity
mmp inhibitor ii is a potent, reversible and broad-range inhibitor of matrix metalloproteinases (mmps) with ic50 values of 24 nm, 18.4 nm, 30 nm and 2.7 nm for mmp-1, mmp-3, mmp-7 and mmp-9, respectively [1].mmps belong to a family of at least fifteen secreted and membrane-bound zinc-endopeptidases. mmps have been engaged in several pathological processes, including tumor growth and metastasis, arthritis, multiple sclerosis, and periodontal disease. these enzymes play a vital role in tissue repair and remodeling via degrading all the extracellular matrix components, including fibrallar and non-fibrallar collagens, laminin, fibronectin, and basement membrane glycoproteins, which enables cell migration. in addition, mmps exert function in metastasis by promoting tumor invasion and angiogenesis. it was shown that the expression of various members of the mmp family by tumors is closely associated with their proliferative and invasive behavior and metastatic potential. furthermore, mmps are broadly sub-divided into three classes: stromelysins, gelatinases, and collagenases, which are secreted in a proenzyme form and require activation to digest an extracellular matrix [1].
References
[1]. slawomir m. wojtowicz-praga, robert b. dickson and michael j. hawkins. matrix metalloproteinase inhibitors. investigational new drugs. 1997; 15: 61–75.