ChemicalBook > CAS DataBase List > NAPHTHOL AS-E PHOSPHATE

NAPHTHOL AS-E PHOSPHATE

Product Name
NAPHTHOL AS-E PHOSPHATE
CAS No.
18228-17-6
Chemical Name
NAPHTHOL AS-E PHOSPHATE
Synonyms
kg-501;NASEP;KD-501;KG-501, 10 mM in DMSO;NAPHTHOL AS-E PHOSPHATE;2-naphthol-AS-E-phosphate;KG-501(NaphtholAS-Ephosphate);KG-501 (2-naphthol-AS-E-phosphate);NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE;NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY
CBNumber
CB9737978
Molecular Formula
C17H13ClNO5P
Formula Weight
377.72
MOL File
18228-17-6.mol
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NAPHTHOL AS-E PHOSPHATE Property

Density 
1.567±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO: soluble
form 
A crystalline solid
pka
1.04±0.30(Predicted)
color 
White to light yellow
BRN 
6664478
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Safety

WGK Germany 
3
F 
8-10-21
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
70485
Product name
Naphthol AS-E phosphate
Purity
for histology
Packaging
250mg
Price
$105
Updated
2024/03/01
TRC
Product number
N368028
Product name
Naphthol AS-E phosphate
Packaging
100mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-0027313
Product name
KG-501
Purity
98.08%
Packaging
10mg
Price
$70
Updated
2021/12/16
Biosynth Carbosynth
Product number
EN69791
Product name
Naphthol AS-E phosphate - 60%
Packaging
500mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
EN69791
Product name
Naphthol AS-E phosphate - 60%
Packaging
250mg
Price
$45
Updated
2021/12/16
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NAPHTHOL AS-E PHOSPHATE Chemical Properties,Usage,Production

Uses

Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis th at oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).

Biological Activity

Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM.

in vitro

Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons.

in vivo

Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex.

target

NAPHTHOL AS-E PHOSPHATE Preparation Products And Raw materials

Raw materials

Preparation Products

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18228-17-6, NAPHTHOL AS-E PHOSPHATERelated Search:

NAPHTHOL AS-D PHOSPHATE NAPHTHOL AS-TR PHOSPHATE, MONOSODIUM SALT NAPHTHOL AS-E PHOSPHATE NAPHTHOL AS-MX PHOSPHATE NAPHTHOL AS-BS PHOSPHATE,NAPHTHOL AS-BS-PHOSPHATE FOR & Naphthol AS-BI-phosphate disodium NAPHTHOL AS-CL PHOSPHATE NAPHTHOL AS-BI PHOSPHATE NAPHTHOL AS-BI PHOSPHATE SODIUM*SIGMAULT RA,NAPHTHOL AS-BI PHOSPHATE SODIUM,NAPHTHOL AS-BI PHOSPHATE SODIUM SALT,naphthol as-bi phosphate disodium salt NAPHTHOL AS-OL PHOSPHATE,NAPHTHOL AS-OL PHOSPHATE HISTOCHEMICAL SUBSTRATE Naphthol AS-E NAPHTHOL AS-MX-PHOSPHATE DISODIUM SALT NONAHYDRATE 99%,NAPHTHOL AS-MX-PHOSPHATE DISODIUM SALT NONAHYDRATE NAPHTHOL AS-TR PHOSPHATE NAPHTHOL AS-GR PHOSPHATE DISODIUM NAPHTHOL AS-BI-PHOSPHATE DISODIUM SALT HEPTAHYDRATE,NAPHTHOL AS-BI-PHOSPHATE, DISODIUM SALT HYDRATE NAPHTHOL AS-MX PHOSPHATE DISODIUM SALT,NAPHTHOL AS-MX PHOSPHATE SODIUM NAPHTHOL AS-GR PHOSPHATE NAPHTHOL AS-AN PHOSPHATE NAPHTHOL FREE,NAPHTHOL AS-AN PHOSPHATE

  • NAPHTHOL AS-E PHOSPHATE
  • N-(4-chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide
  • NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY
  • NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE
  • N-(4-Chlorophenyl)-3-phosphonooxy-2-naphthalenecarboxamide
  • [3-[(4-chlorophenyl)carbamoyl]-2-naphthyl] dihydrogen phosphate
  • kg-501
  • N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE; KG-501; NASEP;NAPHTHOL AS-E PHOSPHATE;KG501;KG 501
  • NASEP
  • 2-naphthol-AS-E-phosphate
  • 2-NAPHTHOL-AS-E-PHOSPHATE;NAPHTHOL AS-E PHOSPHATE
  • [3-[(4-chlorophenyl)carbamoyl]naphthalen-2-yl] dihydrogen phosphate
  • KG-501(NaphtholAS-Ephosphate)
  • KD-501
  • 3-hydroxy-2-(hydroxymethyl)-2-methyl-1-phenyl-1-propanone
  • 2-Naphthalenecarboxamide, N-(4-chlorophenyl)-3-(phosphonooxy)-
  • KG-501 (2-naphthol-AS-E-phosphate)
  • Epigenetic Reader Domain,inhibit,Inhibitor,KG 501,Naphthol AS-E,KG501,KG-501
  • KG-501, 10 mM in DMSO
  • 18228-17-6
  • 8228-17-6
  • 18228-27-6
  • C17H13ClNO5P
  • BioChemical
  • Biochemicals and Reagents
  • Enzyme Substrates
  • Enzymes, Inhibitors, and Substrates
  • Substrates by Enzyme
  • Substrates
  • API
    • TargetValue
    CREB
    ()