ChemicalBook > CAS DataBase List > Piperaquinoline

Piperaquinoline

Product Name
Piperaquinoline
CAS No.
4085-31-8
Chemical Name
Piperaquinoline
Synonyms
piperaquinoline;Piperaquine phosphate;PIRERAQUINE PHOSPHATE;pipieraquine phosphate;4,4'-(1,3-Propanediyldi-4;Piperaquinoline USP/EP/BP;Piperaquine phosphate CP2000;BULK DRUG: PIPERAQUINE PHOSPHATE (DMF GRADE);1,3-Bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)propane;4,4'-(trimethylenedi-4,1-piperazinediyl)bis(7-chloro-quinoline)
CBNumber
CB9744930
Molecular Formula
C29H32Cl2N6
Formula Weight
535.51
MOL File
4085-31-8.mol
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Piperaquinoline Property

Melting point:
198-200 °C
Boiling point:
721.1±60.0 °C(Predicted)
Density 
1.292±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≤0.2mg/ml in DMSO
form 
crystalline solid
pka
8.92±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20799
Product name
Piperaquine
Purity
≥98%
Packaging
10mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
20799
Product name
Piperaquine
Purity
≥98%
Packaging
25mg
Price
$287
Updated
2024/03/01
Cayman Chemical
Product number
20799
Product name
Piperaquine
Purity
≥98%
Packaging
50mg
Price
$543
Updated
2024/03/01
Cayman Chemical
Product number
20799
Product name
Piperaquine
Purity
≥98%
Packaging
100mg
Price
$1024
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
API0009269
Product name
PIPERAQUINE
Purity
95.00%
Packaging
1G
Price
$1067.22
Updated
2021/12/16
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Piperaquinoline Chemical Properties,Usage,Production

Chemical Properties

To class white crystalline powder

Definition

ChEBI: An aminoquinoline that is 1,3-di(piperazin-1-yl)propane in which the nitrogen at position 4 of each of the piperazine moieties is replaced by a 7-chloroquinolin-4-yl group.

Biological Activity

piperaquine, an antimalarial drug, is first synthesised in the 1960s and extensively used as prophylaxis and treatment during the next 20 years.

in vitro

in 280 p. falciparum isolates, the ic50 for piperaquine ranged from 9.8 nm to 217.3 nm and a significant but low correlation was observed between the ic50 values for piperaquine and chloroquine. however, the coefficient of determination indicated that only 2.1% of the variation in the response to piperaquine was explained by the variation in the response to chloroquine. moreover, the mean value for piperaquine was 74.0 nm in the pfcrt k76 wild-type group and 87.7 nm in the 76t mutant group and such difference was not significant [1].

in vivo

male sd rats were orally administered piperaquine or as a short-term i.v. infusion. results showed that piperaquine disposition was best described by a 3-compartment model with a rapid initial distribution phase after i.v. administration. the pk of piperaquine was characterized by a low clearance, a large volume of distribution and a long terminal half-life [2].

IC 50

9.8 to 217.3 nm for p. falciparum isolates

References

[1] pascual a et al. in vitro piperaquine susceptibility is not associated with the plasmodium falciparum chloroquine resistance transporter gene. malar j. 2013 nov 25;12:431.
[2] tarning j, lindegardh n, sandberg s, day nj, white nj, ashton m. pharmacokinetics and metabolism of the antimalarial piperaquine after intravenous and oral single doses to the rat. j pharm sci. 2008 aug;97(8):3400-10.
[3] denis mb, davis tm, hewitt s, incardona s, nimol k, fandeur t, poravuth y, lim c, socheat d. efficacy and safety of dihydroartemisinin-piperaquine (artekin) in cambodian children and adults with uncomplicated falciparum malaria. clin infect dis. 2002 dec 15;35(12):1469-76.

Piperaquinoline Preparation Products And Raw materials

Raw materials

Piperazine

Preparation Products

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View Lastest Price from Piperaquinoline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Piperaquinoline 4085-31-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0% ~ 102.0%
Supply Ability
500kg/month
Release date
2021-06-15
Weijer International Trade (Hebei) Co., Ltd
Product
piperaquine phosphate 4085-31-8
Price
US $1.00/KG
Min. Order
1KG
Purity
>99%
Supply Ability
2000T
Release date
2023-03-21
Anhui Rencheng Technology Co., Ltd
Product
piperaquine phosphate 4085-31-8
Price
US $1.00-499.00/KG
Min. Order
0.5KG
Purity
>99%
Supply Ability
20tons
Release date
2021-01-07

4085-31-8, PiperaquinolineRelated Search:

Piperazine phosphate Primaquine diphosphate BIS-Tris Propane p-Toluenesulfonic acid monohydrate Piperaquine Citrazinic acid Benproperine phosphate PIPERAZINE HYDROGEN PHOSPHATE MONOHYDRATE Propane Piperazine, phosphate (1:?) 7-Chloro-4-piperazinoquinoline Difluorochloromethane 1-(4-Pyridyl)piperazine 7-CHLOROQUINOLINE 7-CHLORO-4-N,N-DIMETHYLAMINO-QUINOLINE DIMETHYL-QUINOLIN-4-YL-AMINE 1-(3-DIETHYLAMINOPROPYL)PIPERAZINE 4-(2-AMINOETHYL)AMINOQUINOLINE

  • 1,3-bis[1-(7-chloro-4-quinolyl)-4'-piperazinyl]propane tetraphosphate tetrahydrate
  • Piperaquine phosphate CP2000
  • PIRERAQUINE PHOSPHATE
  • 4,4'-(1,3-Propanediydi-4,1-piper-azinediyl)bis[7-chloroquinoline]
  • 4,4'-(trimethylenedi-4,1-piperazinediyl)bis(7-chloro-quinoline)
  • piperaquinoline
  • 4,4'-[1,3-Propanediylbis(4,1-piperazinediyl)]bis(7-chloroquinoline)
  • Piperaquine phosphate
  • 7-chloro-4-[4-[3-[4-(7-chloro-4-quinolyl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline
  • 7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline
  • 1,3-Bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)propane
  • BULK DRUG: PIPERAQUINE PHOSPHATE (DMF GRADE)
  • 4,4'-(1,3-Propanediyldi-4
  • 7-chloro-4-[4-[3-[4-(7-chloro-4-quinolinyl)-1-piperazinyl]propyl]-1-piperazinyl]quinoline
  • pipieraquine phosphate
  • 4,4'-(1,3-Propanediyldi-4,1-piperazindiyl)bis(7-chloroquinoline) phosphate
  • Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis[7-chloro-
  • Piperaquinoline USP/EP/BP
  • PiperaquineQ: What is Piperaquine Q: What is the CAS Number of Piperaquine
  • 4085-31-8
  • C29H32Cl2N64H3PO44
  • C29H32Cl2N64H3PO44H2O
  • C29H32Cl2N6H3PO4
  • C29H32Cl2N6
  • C29H32N6Cl2
  • APIS
  • 4085-31-8