5-ETHYL-2-THIOURACIL
- Product Name
- 5-ETHYL-2-THIOURACIL
- CAS No.
- 34171-37-4
- Chemical Name
- 5-ETHYL-2-THIOURACIL
- Synonyms
- 5-ETHYL-2-THIOURACIL;5-Ethyl-2-thiouracil ,98%;5-ETHYL-2-THIOURACIL USP/EP/BP;5-Ethyl-2-thioxo-2,3-dihydropyriMidin-4(1H)-one;4(1H)-Pyrimidinone, 5-ethyl-2,3-dihydro-2-thioxo-;5-ethyl-2-sulfanylidene-1,2,3,4-tetrahydropyriMidin-4-one
- CBNumber
- CB9761278
- Molecular Formula
- C6H8N2OS
- Formula Weight
- 156.21
- MOL File
- 34171-37-4.mol
5-ETHYL-2-THIOURACIL Property
- Melting point:
- 191-193℃
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 7.69±0.25(Predicted)
- color
- Pale Yellow to Pale Beige
Safety
- WGK Germany
- 3
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E926855
- Product name
- 5-Ethyl-2-thiouracil
- Packaging
- 1g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- JK521370
- Product name
- 5-Ethyl-2-thiouracil
- Purity
- 98%
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR926014
- Product name
- 5-Ethyl-2-thiouracil
- Purity
- 95%
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- JK521370
- Product name
- 5-Ethyl-2-thiouracil
- Purity
- 98%
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- W5566
- Product name
- 5-Ethyl-2-thiouracil
- Packaging
- 1g
- Price
- $269
- Updated
- 2021/12/16
5-ETHYL-2-THIOURACIL Chemical Properties,Usage,Production
Chemical Properties
Off-white solid
Uses
5-Ethyl-2-thiouracil is a modified nucleobase and a versatile reactant used in the synthesis. It was used as a reactant in the inhibition of Hepatitis B virus (HBV) replication.
Synthesis
105-54-4
17356-08-0
109-94-4
34171-37-4
Step D75: Synthesis of 5-ethyl-2-thio-2,3-dihydro-4(1H)-pyrimidinone 1. To a suspension of potassium tert-butanolate (12.08 g, 108 mmol) in THF (40 mL) under nitrogen protection was slowly added dropwise a mixed solution of ethyl butyrate (5.69 mL, 43.0 mmol) and ethyl formate (6.93 mL, 86 mmol) in ether (40.0 mL). 2. The reaction mixture was stirred at room temperature for 3 hours. 3. Upon completion of the reaction, the solvent was removed under reduced pressure to give an oily residue. 4. The residue was dissolved in isopropanol (350 mL) and thiourea (6.55 g, 86 mmol) was added. 5. The mixture was heated to reflux and stirred overnight. 6. At the end of the reaction, the reaction solution was concentrated under vacuum to give a solid product. 7. The solid product was dissolved in water and the pH was adjusted to 4 with acetic acid (AcOH). 8. 8. The aqueous phase was extracted with dichloromethane (DCM) and the organic layers were combined. 9. The organic layer was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give 5-ethyl-2-thiouracil (5.5 g, 82% yield) as a pink solid.
References
[1] Patent: WO2012/76435, 2012, A1. Location in patent: Page/Page column 49
5-ETHYL-2-THIOURACIL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-ETHYL-2-THIOURACIL manufacturers
- Product
- 5-Ethyl-2-thiouracil 34171-37-4
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-08-09
- Product
- 5-ETHYL-2-THIOURACIL 34171-37-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-ETHYL-2-THIOURACIL 34171-37-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09