2-[[4-(2-METHOXYPHENYL)PIPERAZIN-1-YL] METHYL]-6-METHYL-2,3-DIHYDROIMIDAZO[1,2C]QUINAZOLIN-5(6H)-ONE

Product Name: 2-[[4-(2-METHOXYPHENYL)PIPERAZIN-1-YL] METHYL]-6-METHYL-2,3-DIHYDROIMIDAZO[1,2C]QUINAZOLIN-5(6H)-ONE
CAS No.: 149847-77-8
Chemical Name: 2-[[4-(2-METHOXYPHENYL)PIPERAZIN-1-YL] METHYL]-6-METHYL-2,3-DIHYDROIMIDAZO[1,2C]QUINAZOLIN-5(6H)-ONE
Synonyms: 2-MPMDQ;2-[[4-(2-METHOXYPHENYL)PIPERAZIN-1-YL] METHYL]-6-METHYL-2,3-DIHYDROIMIDAZO[1,2C]QUINAZOLIN-5(6H)-ONE;2-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-6-methyl-2,6-dihydroimidazo[1,2-c]quinazolin-5(3H)-one;Imidazo[1,2-c]quinazolin-5(3H)-one, 2,6-dihydro-2-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-6-methyl-
CBNumber: CB9771332
Molecular Formula: C23H27N5O2
Formula Weight: 405.49
MOL File: Mol file

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2-[[4-(2-METHOXYPHENYL)PIPERAZIN-1-YL] METHYL]-6-METHYL-2,3-DIHYDROIMIDAZO[1,2C]QUINAZOLIN-5(6H)-ONE Property

storage temp.: Store at RT
solubility: <20.27mg/ml in DMSO
form: Powder

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 0661
Product name: 2-MPMDQ
Packaging: 10
Price: $154
Updated: 2021/12/16

Tocris

Product number: 0661
Product name: 2-MPMDQ
Packaging: 50
Price: $628
Updated: 2021/12/16

TRC

Product number: M745853
Product name: 2-MPMDQ
Packaging: 2.5mg
Price: $195
Updated: 2021/12/16

TRC

Product number: M745853
Product name: 2-MPMDQ
Packaging: 5mg
Price: $330
Updated: 2021/12/16

Usbiological

Product number: 254368
Product name: 2-MPMDQ
Packaging: 10mg
Price: $403
Updated: 2021/12/16

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2-[[4-(2-METHOXYPHENYL)PIPERAZIN-1-YL] METHYL]-6-METHYL-2,3-DIHYDROIMIDAZO[1,2C]QUINAZOLIN-5(6H)-ONE Chemical Properties,Usage,Production

Uses

2-MPMDQ is a novel class of α1-adrenoceptor antagonists and acts as an anti-hypertensive agent.

Definition

ChEBI: 2-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-6-methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5-one is a member of piperazines.

Biological Activity

Potent and selective α 1 -adrenoceptor antagonist; hypotensive.

IC 50

α1-adrenergic receptor: 0.37 nM (Ki); α2-adrenergic receptor: 1740 nM (Ki)

References

[1]. chern jw, tao pl, yen mh, et al. studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. j med chem, 1993, 36(15): 2196-2207.

2-[[4-(2-METHOXYPHENYL)PIPERAZIN-1-YL] METHYL]-6-METHYL-2,3-DIHYDROIMIDAZO[1,2C]QUINAZOLIN-5(6H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[[4-(2-METHOXYPHENYL)PIPERAZIN-1-YL] METHYL]-6-METHYL-2,3-DIHYDROIMIDAZO[1,2C]QUINAZOLIN-5(6H)-ONE Suppliers

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149847-77-8, 2-[[4-(2-METHOXYPHENYL)PIPERAZIN-1-YL] METHYL]-6-METHYL-2,3-DIHYDROIMIDAZO[1,2C]QUINAZOLIN-5(6H)-ONERelated Search:

2-[[4-(2-METHOXYPHENYL)PIPERAZIN-1-YL] METHYL]-6-METHYL-2,3-DIHYDROIMIDAZO[1,2C]QUINAZOLIN-5(6H)-ONE

2-MPMDQ

Imidazo[1,2-c]quinazolin-5(3H)-one, 2,6-dihydro-2-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-6-methyl-

2-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-6-methyl-2,6-dihydroimidazo[1,2-c]quinazolin-5(3H)-one

149847-77-8