ChemicalBook > CAS DataBase List > 6-CHLORO-N-METHYL-NICOTINAMIDE

6-CHLORO-N-METHYL-NICOTINAMIDE

Product Name
6-CHLORO-N-METHYL-NICOTINAMIDE
CAS No.
54189-82-1
Chemical Name
6-CHLORO-N-METHYL-NICOTINAMIDE
Synonyms
6-CHLORO-N-METHYL-NICOTINAMIDE;6-chloro-nicotinic acid N-MethylaMide;3-Pyridinecarboxamide, 6-chloro-N-methyl-
CBNumber
CB9786486
Molecular Formula
C7H7ClN2O
Formula Weight
170.6
MOL File
54189-82-1.mol
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6-CHLORO-N-METHYL-NICOTINAMIDE Property

Melting point:
152.8-153.4 °C(Solv: dichloromethane (75-09-2))
Boiling point:
347.6±27.0 °C(Predicted)
Density 
1.264±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
13.85±0.46(Predicted)
Appearance
White to light yellow Solid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.43924
Product name
6-Chloro-N-methyl nicotinamide
Purity
for synthesis
Packaging
5G
Price
$75.6
Updated
2022/05/15
Sigma-Aldrich
Product number
8.43924
Product name
6-Chloro-N-methyl nicotinamide
Purity
for synthesis
Packaging
25g
Price
$153
Updated
2022/05/15
TRC
Product number
C428858
Product name
6-Chloro-N-methyl nicotinamide
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
5281AE
Product name
6-Chloro-N-methyl nicotinamide
Packaging
10g
Price
$384
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0055430
Product name
6-Chloro-N-methyl nicotinamide
Purity
95.00%
Packaging
1G
Price
$852.55
Updated
2021/12/16
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6-CHLORO-N-METHYL-NICOTINAMIDE Chemical Properties,Usage,Production

Synthesis

58757-38-3

74-89-5

54189-82-1

a) Preparation of 6-chloro-N-methylnicotinamide: 6-chloro-3-pyridinecarbonyl chloride (5.65 g, 32.1 mmol) was dissolved in tetrahydrofuran (64 mL), and triethylamine (5.59 mL, 40.1 mmol) and tetrahydrofuran solution of methylamine (20.1 mL, 40.1 mmol) were added sequentially, and the reaction was carried out under the condition of ice bath. After addition, the ice bath was withdrawn and the reaction was stirred at room temperature for 3.5 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure and the resulting residue was purified by recrystallization (ethyl acetate/hexane) to afford 6-chloro-N-methyl-nicotinamide (5.06 g, 92% yield) as light brown crystals.1H-NMR (CDCl3) δ: 3.05 (3H, d, J = 4.6 Hz), 6.14 (1H, brs), 7.42 (1H, d, J = 8.3 Hz), 8.09 (1H, dd, J = 2.4, 8.3 Hz), 8.72 (1H, d, J = 2.4 Hz).

References

[1] Patent: US2010/280013, 2010, A1. Location in patent: Page/Page column 13
[2] Patent: US2010/48610, 2010, A1. Location in patent: Page/Page column 22
[3] Patent: US2009/69300, 2009, A1. Location in patent: Page/Page column 28
[4] Patent: WO2005/97778, 2005, A1. Location in patent: Page/Page column 26

6-CHLORO-N-METHYL-NICOTINAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-CHLORO-N-METHYL-NICOTINAMIDE Suppliers

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View Lastest Price from 6-CHLORO-N-METHYL-NICOTINAMIDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
6-Chloro-N-methylnicotinamide 54189-82-1
Price
US $3.90-5.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-13
Career Henan Chemical Co
Product
6-CHLORO-N-METHYL-NICOTINAMIDE 54189-82-1
Price
US $3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-04

54189-82-1, 6-CHLORO-N-METHYL-NICOTINAMIDERelated Search:

2-Chloro-N-methyl-nicotinamide 1-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-3-(2,5-DICHLOROPHENYL)IMIDAZOLIDINE-2,4,5-TRIONE 6-chloro-N-(4-methylphenyl)pyridine-3-carboxamide N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(2,5-DICHLOROPHENYL)UREA N3-PHENYL-6-CHLORONICOTINAMIDE 1-[4-(4-CHLOROPHENOXY)PHENYL]-3-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]IMIDAZOLIDINE-2,4,5-TRIONE N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(3,4-DICHLOROPHENYL)UREA N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(2,4-DICHLOROPHENYL)UREA 1-CHLORO-N-(4-CHLOROPHENYL)-N-METHYL-4-ISOQUINOLINECARBOXAMIDE N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(2,6-DICHLOROPHENYL)UREA N-[4-(4-CHLOROPHENOXY)PHENYL]-N'-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]UREA 1-CHLORO-N-(4-CHLOROPHENYL)-4-ISOQUINOLINECARBOXAMIDE N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(3,5-DICHLOROPHENYL)UREA N-(4-CHLOROPHENYL)-N'-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]UREA N3-(4-CHLOROPHENYL)-6-CHLORONICOTINAMIDE N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-PIPERIDINOUREA N3-(2,4-DICHLOROBENZYL)-N3-PROPYL-6-CHLORO-4-(TRIFLUOROMETHYL)NICOTINAMIDE N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-MORPHOLINOUREA

  • 6-CHLORO-N-METHYL-NICOTINAMIDE
  • 6-chloro-nicotinic acid N-MethylaMide
  • 3-Pyridinecarboxamide, 6-chloro-N-methyl-
  • 54189-82-1