SR 142948

Product Name: SR 142948
CAS No.: 184162-64-9
Chemical Name: SR 142948
Synonyms: SR 142948;LWULHXVBLMWCHO-UHFFFAOYSA-N;inhibit,HT 29,Neurotensin Receptor,SR 142948,CHO cells,SR142948,SR-142948,dopamine,neurotensin,Inhibitor,psychotic disorders;2-[(5-(2,6-DIMETHOXY-PHENYL)-1-(4-[(3-DIMETHYLAMINO-PROPYL)-METHYL-CARBAMOYL]-2-ISOPROPYL-PHENYL)-1H-PYRAZOLE-3-CARBONYL)-AMINO]-ADAMANTANE-2-CARBOXYLIC ACID;2-[[[5-(2,6-DIMETHOXYPHENYL)-1-[4-[[[3-(DIMETHYLAMINO)PROPYL]METHYLAMINO]CARBONYL]-2-(1-METHYLETHYL)PHENYL]-1H-PYRAZOL-3-YL]CARBONYL]AMINO]-TRICYCLO[3.3.1.13,7]DECANE-2-CARBOXYLIC ACID;TRICYCLO[3.3.1.13,7]DECANE-2-CARBOXYLIC ACID, 2-[[[5-(2,6-DIMETHOXYPHENYL)-1-[4-[[[3-(DIMETHYLAMINO)PROPYL]METHYLAMINO]CARBONYL]-2-(1-METHYLETHYL)PHENYL]-1H-PYRAZOL-3-YL]CARBONYL]AMINO]-
CBNumber: CB9787670
Molecular Formula: C39H51N5O6
Formula Weight: 685.85214
MOL File: 184162-64-9.mol

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SR 142948 Property

Boiling point:: 824.7±65.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: Soluble to 75 mM in DMSO and to 25 mM in water
form: Powder
pka: 3.28±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23911
Product name: SR 142948
Purity: ≥98%
Packaging: 1mg
Price: $75
Updated: 2021/12/16

Cayman Chemical

Product number: 23911
Product name: SR 142948
Purity: ≥98%
Packaging: 5mg
Price: $175
Updated: 2021/12/16

Cayman Chemical

Product number: 23911
Product name: SR 142948
Purity: ≥98%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

Tocris

Product number: 2309
Product name: SR142948
Purity: ≥97%(HPLC)
Packaging: 10
Price: $298
Updated: 2021/12/16

Tocris

Product number: 2309
Product name: SR142948
Purity: ≥97%(HPLC)
Packaging: 1
Price: $141
Updated: 2021/12/16

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SR 142948 Chemical Properties,Usage,Production

Uses

SR 142948 is an antagonist of NT1/NT2 receptors inhibiting bile acid secretion. Neurotensin receptor antagonist.

Definition

ChEBI: 2-[[[5-(2,6-dimethoxyphenyl)-1-[4-[[3-(dimethylamino)propyl-methylamino]-oxomethyl]-2-propan-2-ylphenyl]-3-pyrazolyl]-oxomethyl]amino]-2-adamantanecarboxylic acid is a N-acyl-amino acid.

Biological Activity

Potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC 50 = 0.32 - 3.96 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo .

in vivo

SR 142948 (2 μg/kg; p.o.; single) inhibits the turning behavior induced by NT (10 pg/mouse)^[2].
SR 142948 (0.01, 0.03, 0.3 mg/kg; i.p.; single) prevents the enhancement of ACh release produced by NT (100 nM), in a dose-dependent manner^[2].
SR 142948 (0-10 mg/kg; p.o.; single) partially but significantly blocks NT-induced hypothermia (53% at 2 mg/kg in rats and 54% at 4 mg/kg in mice)^[2].

Animal Model:	Female Swiss albino CD1 mice (25-30 g; intrastriatal injection of 10 pg/mouse NT)^[2].
Dosage:	2 μg/kg
Administration:	Oral administration; single.
Result:	Inhibited the turning behavior with maximal and significant antagonism between 1-2 h after administration.

storage

Store at +4°C

SR 142948 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR 142948 Suppliers

China 33 United Kingdom 1 United States 6 Global 40

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184162-64-9, SR 142948Related Search:

TRICYCLO[3.3.1.13,7]DECANE-2-CARBOXYLIC ACID, 2-[[[5-(2,6-DIMETHOXYPHENYL)-1-[4-[[[3-(DIMETHYLAMINO)PROPYL]METHYLAMINO]CARBONYL]-2-(1-METHYLETHYL)PHENYL]-1H-PYRAZOL-3-YL]CARBONYL]AMINO]-

SR 142948

2-[(5-(2,6-DIMETHOXY-PHENYL)-1-(4-[(3-DIMETHYLAMINO-PROPYL)-METHYL-CARBAMOYL]-2-ISOPROPYL-PHENYL)-1H-PYRAZOLE-3-CARBONYL)-AMINO]-ADAMANTANE-2-CARBOXYLIC ACID

LWULHXVBLMWCHO-UHFFFAOYSA-N

2-[[[5-(2,6-DIMETHOXYPHENYL)-1-[4-[[[3-(DIMETHYLAMINO)PROPYL]METHYLAMINO]CARBONYL]-2-(1-METHYLETHYL)PHENYL]-1H-PYRAZOL-3-YL]CARBONYL]AMINO]-TRICYCLO[3.3.1.13,7]DECANE-2-CARBOXYLIC ACID

inhibit,HT 29,Neurotensin Receptor,SR 142948,CHO cells,SR142948,SR-142948,dopamine,neurotensin,Inhibitor,psychotic disorders

184162-64-9

C39H51N5O6