D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
- Product Name
- D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
- CAS No.
- 139889-65-9
- Chemical Name
- D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
- Synonyms
- D-THREO-PPMP;D-threo-PPMP (hydrochloride);D threo PPMP hydrochloride,DthreoPPMP hydrochloride;D-threo-PPMP (PPMP), glucosylceramide synthase inhibitor;D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL;R-(R*,R*)]-N-[2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-hexadecanamide,monohydrochloride
- CBNumber
- CB9795831
- Molecular Formula
- C29H51ClN2O3
- Formula Weight
- 511.19
- MOL File
- 139889-65-9.mol
D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Property
- storage temp.
- Store at -20°C
- solubility
- Ethanol: Soluble,Methanol: Soluble
- form
- A solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 22677
- Product name
- D-threo-PPMP (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $210
- Updated
- 2024/03/01
- Product number
- 22677
- Product name
- D-threo-PPMP (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $396
- Updated
- 2024/03/01
D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Chemical Properties,Usage,Production
Description
D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor., It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growth in vitro at 20 μM and significantly inhibits DNA synthesis at 3 μM. [Matreya, LLC. Catalog No. 1865]
Uses
D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP hydrochloride can block karyokinesis and reduce cyst production[1][2].
References
[1] Gouazé V, et, al. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res. 2005 May 1;65(9):3861-7. DOI:10.1158/0008-5472.CAN-04-2329
[2] Hernandez Y. Novel role of sphingolipid synthesis genes in regulating giardial encystation. Infect Immun. 2008 Jul;76(7):2939-49. DOI:10.1128/IAI.00116-08
[3] Wu X, et, al. Liquid chromatography method for quantifying D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (D-threo-PPMP) in mouse plasma and liver. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6;837(1-2):44-8. DOI:10.1016/j.jchromb.2006.03.060
D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Preparation Products And Raw materials
Raw materials
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