1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)-PHENYL-METHANONE
- Product Name
- 1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)-PHENYL-METHANONE
- CAS No.
- 404009-46-7
- Chemical Name
- 1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)-PHENYL-METHANONE
- Synonyms
- AMA37;DNA-PK INHIBITOR V;ARYLMORPHOLINE ANALOG 37;(2-Hydroxy-4-morpholinophenyl)(phenyl)methanone;1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)-PHENYL-METHANONE
- CBNumber
- CB9803763
- Molecular Formula
- C17H18NO3
- Formula Weight
- 284.32972
- MOL File
- Mol file
1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)-PHENYL-METHANONE Property
- storage temp.
- Store at -20°C
- form
- Solid
- color
- White to yellow
N-Bromosuccinimide Price
- Product number
- 260964
- Product name
- DNA-PK Inhibitor V - CAS 404009-46-7 - Calbiochem
- Packaging
- 5mg
- Price
- $575
- Updated
- 2024/03/01
- Product number
- 260964
- Product name
- DNA-PK Inhibitor V - CAS 404009-46-7 - Calbiochem
- Packaging
- 1mg
- Price
- $209
- Updated
- 2023/01/07
1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)-PHENYL-METHANONE Chemical Properties,Usage,Production
Definition
ChEBI: [2-hydroxy-4-(4-morpholinyl)phenyl]-phenylmethanone is a member of benzophenones.
Biological Activity
AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively[1][2]. AMA-37 inhbits PI3K poorly[2].AMA-37 (20 μM) reduces the ability of UCN-01, isogranulatimide, and debromohymenialdesine, but not caffeine, to overcome G2 arrest (Ρ < 0.05)[3].Inhibition of DNA-PK with AMA37 leads to radiosensitization[3].
References
[1]. Zachary A Knight, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. [2]. Zachary A Knight, et al. Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorg Med Chem. 2004 Sep 1;12(17):4749-59. [3]. Christopher M Sturgeon, et al. Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage. Mol Cancer Ther. 2006 Apr;5(4):885-92.
1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)-PHENYL-METHANONE Preparation Products And Raw materials
Raw materials
Preparation Products
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