Apcin-A

Product Name: Apcin-A
CAS No.: 1683617-62-0
Chemical Name: Apcin-A
Synonyms: Apcin-A;ApcinA,Apcin A;3-Aminopropyl (2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl)carbamate;3-aminopropyl N-{2,2,2-trichloro-1-[(pyrimidin-2-yl)amino]ethyl}carbamate;Carbamic acid, N-[2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-, 3-aminopropyl ester
CBNumber: CB98054314
Molecular Formula: C10H14Cl3N5O2
Formula Weight: 342.61
MOL File: 1683617-62-0.mol

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Apcin-A Property

Density: 1.499±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (291.88 mM; Need ultrasonic)
pka: 9.84±0.46(Predicted)
form: Solid
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0114386
Product name: Apcin-A
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0114386
Product name: Apcin-A
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0114386
Product name: Apcin-A
Packaging: 25mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0114386
Product name: Apcin-A
Packaging: 50mg
Price: $1450
Updated: 2021/12/16

ChemScene

Product number: CS-0114386
Product name: Apcin-A
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

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Apcin-A Chemical Properties,Usage,Production

Uses

Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V (HY-130257)[1].

References

[1] Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964(19)30677-2. DOI:10.1016/j.ebiom.2019.10.013

Apcin-A Preparation Products And Raw materials

Raw materials

Preparation Products

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Apcin-A Suppliers

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1683617-62-0, Apcin-ARelated Search:

Apcin-A

ApcinA,Apcin A

Carbamic acid, N-[2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-, 3-aminopropyl ester

3-Aminopropyl (2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl)carbamate

3-aminopropyl N-{2,2,2-trichloro-1-[(pyrimidin-2-yl)amino]ethyl}carbamate

1683617-62-0