DBCO-PEG2-acid

Product Name: DBCO-PEG2-acid
CAS No.: 2304558-25-4
Chemical Name: DBCO-PEG2-acid
Synonyms: DBCO-PEG2-COOH;DBCO-PEG2-acid
CBNumber: CB98054697
Molecular Formula: C26H28N2O6
Formula Weight: 464.51
MOL File: 2304558-25-4.mol

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DBCO-PEG2-acid Property

Boiling point:: 803.0±65.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: -20°C, protect from light
solubility: Soluble in DMSO, DCM, DMF
pka: 4.28±0.10(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24290
Product name: DBCO-PEG2-acid
Purity: 97%
Packaging: 25mg
Price: $170
Updated: 2021/12/16

BroadPharm

Product number: BP-24290
Product name: DBCO-PEG2-acid
Purity: 97%
Packaging: 100mg
Price: $380
Updated: 2021/12/16

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DBCO-PEG2-acid Chemical Properties,Usage,Production

Description

DBCO-PEG2-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

DBCO-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG2-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

DBCO-PEG2-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-PEG2-acid Suppliers

China 26 United States 3 Global 29

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q2635253576
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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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Alfa Chemistry

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TargetMol Chemicals Inc.

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Henan Lien Chemical Products Co., Ltd.

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Guangzhou Younan Technology Co., Ltd

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Shanghai Haohong Pharmaceutical Co., Ltd.

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Zhengzhou Convergence Chemical Co. LTD

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2304558-25-4, DBCO-PEG2-acidRelated Search:

DBCO-PEG2-acid

DBCO-PEG2-COOH

2304558-25-4