(2S,3R)-3-(3,4-DIFLUOROPHENYL)-2-(4-FLUOROPHENYL)-4-HYDROXY-N-((3S)-2-OXO-5-PHENYL-2,3-1H-BENZO[E][1,4]DIAZEPIN-3-YL)BUTYRAMIDE

ChemicalBook > CAS DataBase List > (2S,3R)-3-(3,4-DIFLUOROPHENYL)-2-(4-FLUOROPHENYL)-4-HYDROXY-N-((3S)-2-OXO-5-PHENYL-2,3-1H-BENZO[E][1,4]DIAZEPIN-3-YL)BUTYRAMIDE

(2S,3R)-3-(3,4-DIFLUOROPHENYL)-2-(4-FLUOROPHENYL)-4-HYDROXY-N-((3S)-2-OXO-5-PHENYL-2,3-1H-BENZO[E][1,4]DIAZEPIN-3-YL)BUTYRAMIDE

Product Name: (2S,3R)-3-(3,4-DIFLUOROPHENYL)-2-(4-FLUOROPHENYL)-4-HYDROXY-N-((3S)-2-OXO-5-PHENYL-2,3-1H-BENZO[E][1,4]DIAZEPIN-3-YL)BUTYRAMIDE
CAS No.: 2081093-21-0
Chemical Name: (2S,3R)-3-(3,4-DIFLUOROPHENYL)-2-(4-FLUOROPHENYL)-4-HYDROXY-N-((3S)-2-OXO-5-PHENYL-2,3-1H-BENZO[E][1,4]DIAZEPIN-3-YL)BUTYRAMIDE
Synonyms: COMPOUND 34;CHMFL-ABL/KIT-155;GAMMA-SECRETASE INHIBITOR XIX;CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155;CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; COMPOUND 34);(2S,3R)-3-(3,4-DIFLUOROPHENYL)-2-(4-FLUOROPHENYL)-4-HYDROXY-N-((3S)-2-OXO-5-PHENYL-2,3-1H-BENZO[E][1,4]DIAZEPIN-3-YL)BUTYRAMIDE;(2S,3R)-3-(3,4-DIFLUOROPHENYL)-2-(4-FLUOROPHENYL)-4-HYDROXY-N-((3S)-2-OXO-5-PHENYL-2,3-DIHYDRO-1H-BENZO[E][1,4]DIAZEPIN-3-YL)-BUTYRAMIDE;Benzamide, N-[4-methyl-3-[[1-[(6-methyl-3-pyridinyl)carbonyl]-4-piperidinyl]oxy]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-
CBNumber: CB9806092
Molecular Formula: C33H38F3N5O3
Formula Weight: 609.68
MOL File: Mol file

Less

(2S,3R)-3-(3,4-DIFLUOROPHENYL)-2-(4-FLUOROPHENYL)-4-HYDROXY-N-((3S)-2-OXO-5-PHENYL-2,3-1H-BENZO[E][1,4]DIAZEPIN-3-YL)BUTYRAMIDE Property

Boiling point:: 660.5±55.0 °C(Predicted)
Density: 1.271±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 12.67±0.70(Predicted)

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Usbiological

Product number: 044678
Product name: Compound 34
Packaging: 200ug
Price: $312
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0009791
Product name: COMPOUND 34
Purity: 95.00%
Packaging: 5MG
Price: $515
Updated: 2021/12/16

Less

(2S,3R)-3-(3,4-DIFLUOROPHENYL)-2-(4-FLUOROPHENYL)-4-HYDROXY-N-((3S)-2-OXO-5-PHENYL-2,3-1H-BENZO[E][1,4]DIAZEPIN-3-YL)BUTYRAMIDE Chemical Properties,Usage,Production

Description

CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s of 46 nM and 75 nM, respectively), and it also presents significant inhibitory activities to BLK (IC50=81 nM), CSF1R (IC50=227 nM), DDR1 (IC50=116 nM), DDR2 (IC50=325 nM), LCK (IC50=12 nM) and PDGFRβ (IC50=80 nM) kinases. CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) arrests cell cycle progression and induces apoptosis[1]. IC50: 46 nM (type II ABL), 75 nM (c-KIT), 81 nM (BLK), 227 nM (CSF1R), 116 nM (DDR1), 325 nM (DDR2), 12 nM (LCK), 80 nM (PDGFRβ)[1]

CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) exhibits anti-proliferation activities in the BCR-ABL dependent CML cancer cell lines such as K562 (GI50: 0.027 µM), MEG-01 (GI50: 0.02 µM), and KU812 (GI50: 0.056 µM). It also potently inhibits the growth of c-KIT dependent GISTs cancer cell lines including GIST-T1 (GI50: 0.023 µM), GIST-882 (GI50: 0.095 µM) but not c-KIT independent GIST-48B (GI50: 3.96 µM) [1].

CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) (25-100 mg/kg; p.o.; once daily for 28 days) shows dose-dependent tumor progression suppression without apparent toxicity in female nu/nu mice bearing established K562 tumor xenografts[1].

References

[1]. Wang Q, et al. Discovery of 4-Methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-yl)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge Binding. J Med Chem. 2017 Jan 12;60(1):273-289.

(2S,3R)-3-(3,4-DIFLUOROPHENYL)-2-(4-FLUOROPHENYL)-4-HYDROXY-N-((3S)-2-OXO-5-PHENYL-2,3-1H-BENZO[E][1,4]DIAZEPIN-3-YL)BUTYRAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

(2S,3R)-3-(3,4-DIFLUOROPHENYL)-2-(4-FLUOROPHENYL)-4-HYDROXY-N-((3S)-2-OXO-5-PHENYL-2,3-1H-BENZO[E][1,4]DIAZEPIN-3-YL)BUTYRAMIDE Suppliers

China 36 Switzerland 2 United States 6 Global 44

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Shanghai Yiyan Biotechnology Co. , Ltd.

Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Country: China
ProdList: 7979
Advantage: 58

Beijing Luyuan Bird Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 15810802415@139.com
Country: CHINA
ProdList: 6750
Advantage: 58

Shanghai Silk Dragon Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 3988
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6648
Advantage: 58

Beijing Sizhengbai Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: marketing@4abio.com
Country: CHINA
ProdList: 6401
Advantage: 58

Beijing Taize Jiaye Technology Development Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6050
Advantage: 58

Hangzhou Lianke Biotechnology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6349
Advantage: 58

Shanghai Haoran Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 470003480@QQ.COM
Country: CHINA
ProdList: 6955
Advantage: 58

Fujifilm Wako (Guangzhou) Trading Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 1409
Advantage: 58

Beijing Anbiqi Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@abace-biology.com
Country: CHINA
ProdList: 2529
Advantage: 58

Shanghai Yaoyun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 912529879@qq.com
Country: CHINA
ProdList: 6835
Advantage: 58

Qiyi Biotechnology (Shanghai) Co., Ltd.

Tel: --
Fax: --
Email: qiyibio@163.com
Country: CHINA
ProdList: 6105
Advantage: 58

Beijing Lebo Biotechnology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6057
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6936
Advantage: 58

Beijing Chief-East Tech Co.,Ltd (Qwbio)

Tel: --
Fax: --
Email: info@qwbio.com
Country: China
ProdList: 6912
Advantage: 50

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6025
Advantage: 58

Beijing Shengke Boyuan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 978560024@qq.com
Country: CHINA
ProdList: 6005
Advantage: 58

Beijing Bai Ao Si Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: yangmei@bioneeds.net
Country: CHINA
ProdList: 6999
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6973
Advantage: 58

Shanghai Jijin Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: jijinhuaxue@sina.com
Country: CHINA
ProdList: 6606
Advantage: 58

Shenzhen Branch Science and Technology Co., Ltd.

Tel: --
Fax: --
Email: zikerbio@163.com
Country: CHINA
ProdList: 6478
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Minmin Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1914109725@qq.com
Country: CHINA
ProdList: 6518
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: market@xlswkj.com
Country: CHINA
ProdList: 6793
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: tech@chinabiovision.com
Country: CHINA
ProdList: 2731
Advantage: 58

Guangzhou Weijia Technology Co., Ltd.

Tel: --
Fax: --
Email: WHIGA22@126.COM
Country: CHINA
ProdList: 6748
Advantage: 58

Boppard-China

Tel: --
Fax: --
Email: info@boppard.cn
Country: China
ProdList: 687
Advantage: 58

Shenzhen Xinbosheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: service@neobioscience.com
Country: CHINA
ProdList: 6151
Advantage: 58

Morning Student Science and Technology (Guangzhou) Co., Ltd.

Tel: --
Fax: --
Email: chenxue_gz@163.com
Country: CHINA
ProdList: 6600
Advantage: 58

Boao Pike

Tel: --
Fax: --
Email: lyn@biopike.com.cn
Country: CHINA
ProdList: 6629
Advantage: 58

Shanghai Ziqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2453006496@qq.com
Country: CHINA
ProdList: 6184
Advantage: 58

Shanghai Yijie Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: SHYIJIEBIO@126.COM
Country: CHINA
ProdList: 3510
Advantage: 58

2081093-21-0, (2S,3R)-3-(3,4-DIFLUOROPHENYL)-2-(4-FLUOROPHENYL)-4-HYDROXY-N-((3S)-2-OXO-5-PHENYL-2,3-1H-BENZO[E][1,4]DIAZEPIN-3-YL)BUTYRAMIDERelated Search:

GAMMA-SECRETASE INHIBITOR

(2S,3R)-3-(3,4-DIFLUOROPHENYL)-2-(4-FLUOROPHENYL)-4-HYDROXY-N-((3S)-2-OXO-5-PHENYL-2,3-1H-BENZO[E][1,4]DIAZEPIN-3-YL)BUTYRAMIDE

(2S,3R)-3-(3,4-DIFLUOROPHENYL)-2-(4-FLUOROPHENYL)-4-HYDROXY-N-((3S)-2-OXO-5-PHENYL-2,3-DIHYDRO-1H-BENZO[E][1,4]DIAZEPIN-3-YL)-BUTYRAMIDE

COMPOUND 34

GAMMA-SECRETASE INHIBITOR XIX

CHMFL-ABL/KIT-155

CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155

CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; COMPOUND 34)

Benzamide, N-[4-methyl-3-[[1-[(6-methyl-3-pyridinyl)carbonyl]-4-piperidinyl]oxy]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-

2081093-21-0