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HS-243

Product Name
HS-243
CAS No.
848249-10-5
Chemical Name
HS-243
Synonyms
HS-243;Benzamide, 3-nitro-N-(1-propyl-1H-benzimidazol-2-yl)-;3-nitro-N-(1-propyl-1H-benzo[d]imidazol-2-yl)benzamide;RA-FLSs,Inhibitor,immunology,autoimmune disease,inhibit,Interleukin-1 receptor associated kinase,tumor necrosis factor,interleukin,HS243,IRAK,HS-243,rheumatoid arthritis,H460,IL-1R associated kinase,THP-1,Cyclin dependent kinase,HS 243,AN3-CA,TNF,anti-inflammatory,CDK
CBNumber
CB98077937
Molecular Formula
C17H16N4O3
Formula Weight
324.33
MOL File
848249-10-5.mol
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HS-243 Property

Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 41.67 mg/mL (128.48 mM; Need ultrasonic)
form 
Solid
pka
11.59±0.43(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem
Product number
Axon3217
Product name
HS-243
Purity
100%
Packaging
25mg
Price
$319
Updated
2021/12/16
Axon Medchem
Product number
Axon3217
Product name
HS-243
Purity
100%
Packaging
2x25mg
Price
$506
Updated
2021/12/16
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HS-243 Chemical Properties,Usage,Production

Uses

HS-243 is a potent and selective IRAK-4 and IRAK-1 inhibitor, with IC50 values of 20 and 24 nM. HS-243 shows minimal TAK1 (transforming growth factor β-activated kinase 1) inhibition activity, with a IC50 of 0.5 μM. HS-243 shows anti-inflammatory and anticancer activity[1].

IC 50

IRAK4: 20 nM (IC50); IRAK-1: 24 nM (IC50); CLK4: 662 nM (IC50)

References

[1] Scarneo SA, et al. A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase. J Biol Chem. 2020 Feb 7;295(6):1565-1574. DOI:10.1074/jbc.RA119.011857

HS-243 Preparation Products And Raw materials

Raw materials

Preparation Products

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HS-243 Suppliers

China 37 United States 2 Global 39
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
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55
ShangHai Angti Biotechnology Co., Ltd.
Tel
13764913901
Fax
-
Email
info@angtibio.com
Country
China
ProdList
4985
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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62
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1944
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55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
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58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
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58

848249-10-5, HS-243Related Search:


  • HS-243
  • Benzamide, 3-nitro-N-(1-propyl-1H-benzimidazol-2-yl)-
  • 3-nitro-N-(1-propyl-1H-benzo[d]imidazol-2-yl)benzamide
  • RA-FLSs,Inhibitor,immunology,autoimmune disease,inhibit,Interleukin-1 receptor associated kinase,tumor necrosis factor,interleukin,HS243,IRAK,HS-243,rheumatoid arthritis,H460,IL-1R associated kinase,THP-1,Cyclin dependent kinase,HS 243,AN3-CA,TNF,anti-inflammatory,CDK
  • 848249-10-5