ChemicalBook > CAS DataBase List > 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
- Product Name
- 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
- CAS No.
- 2407829-65-4
- Chemical Name
- 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
- Synonyms
- WUN-29654;CRBN modulator-1;CRBN modulator-1, 10 mM in DMSO;2-(2,6-Dioxopiperidin-3-yl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione;1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-;3-(2,6-dioxopiperidin-3-yl)-7-hydroxy-3-azatricyclo[7.3.1.0?,13]trideca-1(13),5,7,9,11-pentaene-2,4-dione;3-(2,6-dioxopiperidin-3-yl)-11-hydroxy-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13),5,7,9,11-pentaene-2,4-dione;CRBN modulator1,CRBN modulator-1,inhibit,CRBN modulator 1,Ligands for E3 Ligase,E3 ligase-recruiting Moiety,Inhibitor
- CBNumber
- CB98096800
- Molecular Formula
- C17H12N2O5
- Formula Weight
- 324.29
- MOL File
- 2407829-65-4.mol
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1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Property
- Boiling point:
- 680.0±50.0 °C(Predicted)
- Density
- 1.587±0.06 g/cm3(Predicted)
- solubility
- DMSO : 10 mg/mL (30.84 mM; ultrasonic and adjust pH to 2 with HCl)
- form
- Solid
- pka
- 8.27±0.20(Predicted)
- color
- Light green to green
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N-Bromosuccinimide Price
DC Chemicals
- Product number
- DC42464
- Product name
- CRBNmodulator-1
- Purity
- >98%
- Packaging
- 100mg
- Price
- $750
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC42464
- Product name
- CRBNmodulator-1
- Purity
- >98%
- Packaging
- 1g
- Price
- $2900
- Updated
- 2021/12/16
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1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Chemical Properties,Usage,Production
Biological Activity
CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM[1].
References
[1]. Nathanael Gray, et al. New crbn modulators. WO2020006262A1.
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Preparation Products And Raw materials
Raw materials
Preparation Products
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1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Suppliers
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