ChemicalBook > CAS DataBase List > 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-

Product Name
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
CAS No.
2407829-65-4
Chemical Name
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
Synonyms
WUN-29654;CRBN modulator-1;CRBN modulator-1, 10 mM in DMSO;2-(2,6-Dioxo-3-piperidyl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione;2-(2,6-Dioxopiperidin-3-yl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione;1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-;3-(2,6-dioxopiperidin-3-yl)-7-hydroxy-3-azatricyclo[7.3.1.0?,13]trideca-1(13),5,7,9,11-pentaene-2,4-dione;3-(2,6-dioxopiperidin-3-yl)-11-hydroxy-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13),5,7,9,11-pentaene-2,4-dione;CRBN modulator1,CRBN modulator-1,inhibit,CRBN modulator 1,Ligands for E3 Ligase,E3 ligase-recruiting Moiety,Inhibitor
CBNumber
CB98096800
Molecular Formula
C17H12N2O5
Formula Weight
324.29
MOL File
2407829-65-4.mol
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1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Property

Boiling point:
680.0±50.0 °C(Predicted)
Density 
1.587±0.06 g/cm3(Predicted)
solubility 
DMSO : 10 mg/mL (30.84 mM; ultrasonic and adjust pH to 2 with HCl)
form 
Solid
pka
8.27±0.20(Predicted)
color 
Light green to green
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals
Product number
DC42464
Product name
CRBNmodulator-1
Purity
>98%
Packaging
100mg
Price
$750
Updated
2021/12/16
DC Chemicals
Product number
DC42464
Product name
CRBNmodulator-1
Purity
>98%
Packaging
1g
Price
$2900
Updated
2021/12/16
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1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Chemical Properties,Usage,Production

Uses

CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM[1].

Biological Activity

CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM[1].

IC 50

Cereblon

References

[1]. Nathanael Gray, et al. New crbn modulators. WO2020006262A1.

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Suppliers

China 41 United States 1 Global 42
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
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2407829-65-4, 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-Related Search:


  • 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
  • WUN-29654
  • CRBN modulator-1
  • 2-(2,6-Dioxopiperidin-3-yl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione
  • CRBN modulator1,CRBN modulator-1,inhibit,CRBN modulator 1,Ligands for E3 Ligase,E3 ligase-recruiting Moiety,Inhibitor
  • 3-(2,6-dioxopiperidin-3-yl)-7-hydroxy-3-azatricyclo[7.3.1.0?,13]trideca-1(13),5,7,9,11-pentaene-2,4-dione
  • 3-(2,6-dioxopiperidin-3-yl)-11-hydroxy-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13),5,7,9,11-pentaene-2,4-dione
  • CRBN modulator-1, 10 mM in DMSO
  • 2-(2,6-Dioxo-3-piperidyl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione
  • 2407829-65-4