JTC 801

Product Name: JTC 801
CAS No.: 244218-51-7
Chemical Name: JTC 801
Synonyms: CS-161;JTC 801;JTC 801 HCl;JTC-801/JTC801;JTC 801 USP/EP/BP;JTC-801 >=98% (HPLC);JTC-801 hydrochloride;JTC-801, 10 mM in DMSO;N-(4-Amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamidehydrochloride;N-(4-AMino-2-Methyl-quinolin-6-yl)-2-(4-ethyl-phenoxyMethyl)-benzaMide hydrochloride
CBNumber: CB9812002
Molecular Formula: C26H25N3O2.ClH
Formula Weight: 447.963
MOL File: 244218-51-7.mol

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JTC 801 Property

Melting point:: 235℃
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO: ≥20mg/mL
form: powder
color: tan
InChIKey: NQLIYKXNAXKMBL-UHFFFAOYSA-N
SMILES: C(=O)(C1C=CC=CC=1COC1C=CC(CC)=CC=1)NC1C=CC2=NC(C)=CC(N)=C2C=1.Cl

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: J3955
Product name: JTC-801
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $130
Updated: 2025/07/31

Sigma-Aldrich

Product number: J3955
Product name: JTC-801
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $519
Updated: 2025/07/31

Cayman Chemical

Product number: 21254
Product name: JTC 801
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 21254
Product name: JTC 801
Purity: ≥98%
Packaging: 10mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 21254
Product name: JTC 801
Purity: ≥98%
Packaging: 25mg
Price: $249
Updated: 2024/03/01

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JTC 801 Chemical Properties,Usage,Production

Uses

JTC 801 is a novel opioid receptor-like1 (ORL1) receptor antagonist.

Biological Activity

High affinity, selective NOP receptor antagonist (K i = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human μ -, κ - and δ -opioid receptors respectively. In vivo shows anti-nociceptive effects in acute pain models. Orally active.

in vivo

JTC-801 (≥0.01?mg/kg, i.v. or 1?mg/kg, p.o.) antagonizes the nociceptin-induced allodynia in mice. In mouse hot-plate test, JTC-801 prolongs escape response latency (ERL) to exposed heat stimulus with minimum effective doses (MED) of 0.01?mg/kg by i.v. or 1?mg/kg by p.o. In the rat formalin test, JTC-801 reduces both the first and second phases of the nociceptive response with MED of 0.01?mg/kg by i.v. administration or 1?mg/kg by p.o. administration. This anti-nociceptive action of JTC-801 is not inhibited by naloxone (10?mg/kg, s.c.). JTC-801 antagonizes the ORL1 receptor response, and has efficacious and potent anti-nociceptive effects in acute pain animal models not only by intravenous injection but also oral administration^[1]. JTC-801 (0.3 mg/kg) decreases allodynia induced by the intrathecal injection of nociceptin in mice^[2]. JTC-801 (6 mg/kg i.p., once daily) reverses SPS-induced mechanical allodynia, thermal hyperalgesia, anxiety-like behaviour and hypocortisolism. JTC-801 treatment also reverses NOP receptor protein and mRNA up-regulation in amygdala and PAG. JTC-801 blocks elevated N/OFQ levels in serum, CSF, PAG and hippocampus at day 21 of SPS^[3]. JTC-801 (0.05-5 mg/kg, i.p.) supresses the the analgesic effect of N2O in 129Sv mice by the writhing test and tail flick test^[4].

IC 50

NOP Receptor/ORL1

storage

Desiccate at RT

JTC 801 Preparation Products And Raw materials

Raw materials

Preparation Products

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JTC 801 Suppliers

China 111 Germany 1 United Kingdom 1 United States 16 Global 129

Shijiazhuang Molechem PharmaTech Co.Ltd

Tel: 18103213005
Email: molechem2024@163.com
Country: China
ProdList: 36
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
Advantage: 55

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

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View Lastest Price from JTC 801 manufacturers

Career Henan Chemical Co

Product: JTC 801 244218-51-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

244218-51-7, JTC 801Related Search:

N-Methylbenzylamine 2-Methylaminoethanol N-Methyldiethanolamine SB 415286 NSC319726 PD 0325901 Ozagrel 4,6-DIAMINO-2-METHYL-QUINOLINE 2-(PHENOXYMETHYL)BENZYLAMINE 97 N-METHYL-2-(PHENOXYMETHYL)BENZYLAMINE JTC 801

JTC 801

N-(4-Amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamidehydrochloride

N-(4-Amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamide monohydrochloride

JTC 801 HCl

JTC-801 hydrochloride

JTC-801/JTC801

N-(4-AMino-2-Methyl-quinolin-6-yl)-2-(4-ethyl-phenoxyMethyl)-benzaMide hydrochloride

Benzamide,N-(4-amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]-, hydrochloride

CS-161

JTC-801 >=98% (HPLC)

JTC 801 USP/EP/BP

JTC-801, 10 mM in DMSO

244218-51-7

Inhibitors