1H-Indole-3-acetic acid, 5-phenyl-

Product Name: 1H-Indole-3-acetic acid, 5-phenyl-
CAS No.: 168649-23-8
Chemical Name: 1H-Indole-3-acetic acid, 5-phenyl-
Synonyms: 5-Ph-IAA;5-Ph-IAA, 10 mM in DMSO;5-(2-phenyl)-indole-3-acetic acid;1H-Indole-3-acetic acid, 5-phenyl-;2-(5-Phenyl-1H-indol-3-yl)acetic acid;inhibit,antitumor,OsTIR1,Inhibitor,auxin,5 Ph IAA,5PhIAA,AID2
CBNumber: CB98130298
Molecular Formula: C16H13NO2
Formula Weight: 251.28
MOL File: 168649-23-8.mol

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1H-Indole-3-acetic acid, 5-phenyl- Property

Boiling point:: 521.3±35.0 °C(Predicted)
Density: 1.291±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 125 mg/mL (497.45 mM)
form: A solid
pka: 4.47±0.30(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3574
Product name: 5-Ph-IAA
Purity: ≥97% (HPLC)
Packaging: 5MG
Price: $79
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3574
Product name: 5-Ph-IAA
Purity: ≥97% (HPLC)
Packaging: 25MG
Price: $319
Updated: 2024/03/01

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1H-Indole-3-acetic acid, 5-phenyl- Chemical Properties,Usage,Production

Biological Activity

5-Ph-IAA is a derivative of IAA. 5-Ph-IAA is a ligand that together with the OsTIR1 (F74G) mutant establishes the auxin-inducible degron 2 system (AID2). AID2 induces rapid and efficient depletion of mAID fusion proteins to study protein function in living cells. AID2 can suppress tumors.

in vitro

HCT116 cells constitutively expressing OsTIR1(F74G) are exposed to 5-Ph-IAA (1 μM; 6 hours), leading to DHC1-mAC degradation, which means the AID2 system better than the original AID system in generating conditional mutant cell lines.

Western Blot Analysis

Cell Line:	HCT116 cells
Concentration:	1 μM
Incubation Time:	6 hours
Result:	Depleted DHC1-mAC efficiently in HCT116 cells constitutively expressing OsTIR1(F74G).

in vivo

5-Ph-IAA (0-10 mg/kg; intraperitoneally injection; every day; 7 days), used for the AID2 system , is sufficient to deplete mAID-BRD4 and TOP2A-mAC, leading to tumor suppression.

Animal Model:	Balb/c-nu female mice (7 weeks old; 16–20 g ) bearing mAID-BRD4 and TOP2A-mAC xenograft tumours cells
Dosage:	0 mg/kg, 1 mg/kg , 3 mg/kg and 10 mg/kg
Administration:	Intraperitoneally injection; every day; 7 days
Result:	Displayed significant tumor suppression of mAID-BRD4 xenografts and TOP2A-mAC xenografts .

storage

Store at -20°C

1H-Indole-3-acetic acid, 5-phenyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Indole-3-acetic acid, 5-phenyl- Suppliers

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168649-23-8, 1H-Indole-3-acetic acid, 5-phenyl-Related Search:

1H-Indole-3-acetic acid, 5-phenyl-

5-Ph-IAA

5-(2-phenyl)-indole-3-acetic acid

inhibit,antitumor,OsTIR1,Inhibitor,auxin,5 Ph IAA,5PhIAA,AID2

2-(5-Phenyl-1H-indol-3-yl)acetic acid

5-Ph-IAA, 10 mM in DMSO

168649-23-8