YQ128

Product Name: YQ128
CAS No.: 2454246-18-3
Chemical Name: YQ128
Synonyms: YQ128;YQ128, 10 mM in DMSO;YQ128,inhibit,YQ 128,Inhibitor,NOD-like Receptor (NLR),Interleukin Related,YQ-128;3-Thiopheneacetamide, N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]-;N-[(5-chloro-2-propoxyphenyl)methyl]-N-(2-{4-[(pr op-2-yn-1-yl)sulfamoyl]phenyl}ethyl)-2-(thiophen- 3-yl)acetamide
CBNumber: CB98199880
Molecular Formula: C27H29ClN2O4S2
Formula Weight: 545.11
MOL File: 2454246-18-3.mol

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YQ128 Property

Boiling point:: 705.8±70.0 °C(Predicted)
Density: 1.287±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 250 mg/mL (458.62 mM)
form: A crystalline solid
pka: 9.32±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0106043
Product name: YQ128
Purity: 99.65%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0106043
Product name: YQ128
Purity: 99.65%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0106043
Product name: YQ128
Purity: 99.65%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0106043
Product name: YQ128
Purity: 99.65%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

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YQ128 Chemical Properties,Usage,Production

Biological Activity

YQ128 is a potent and selective second-generation NLRP3 inflammasome inhibitor with IC50 of 0.30 μM. YQ128 significantly and selectively inhibited the production of IL-1β, but not TNF-α. YQ128 can cross the blood-brain barrier to reach the central nervous system. YQ128 has anti-inflammatory activity.

in vitro

YQ128 (0.3-100 μM; 30 mins) dose dependently suppressed the release of IL-1β from peritoneal macrophages upon LPS/ATP challenge with an IC ₅₀ of 1.59 μM.
YQ128 (20 μM; 2 hours) shows no significant toxic effects on hCMEC/D3 cells.

Cell Viability Assay

< td class="col1"> Cell Line:

Mouse peritoneal macrophages
Concentration:	0.3, 1.0, 3.0, 10, 30, 100 μM
Incubation Time:	30 mins
Result:	Suppressed the release of IL-1β from peritoneal macrophages upon LPS/ATP challenge with an IC ₅₀ of 1.59 μM.

in vivo

YQ128 (iv; 20 mg/kg) has an intermediate terminal plasma half-life (t _1/2 ) of 6.6 hours after iv administration.
YQ128 (oral ; 20 mg/kg) shows delayed gastrointestinal absorption with at _max and c _max of 12 h and 73 ng/mL, respectively. Oral bioavailability (F _{oral < /sub> ) is estimated as 10%.
YQ128 exhibits extensive extravascular distribution with a large steady-state volume of distribution (Vd _ss ) of 8.5 L/kg and rapid total clearance (CL _tot ) of 41 mL/min/kg.
has been shown to trigger IL-1β production in a NLRP3-dependent manner in C57BL/6 mice. < /p>}

< tr> Administration: < td class="col2"> Had an intermediate terminal plasma half-life (t _1/2 ) of 6.6 hours after iv administration.

Animal Model:	Sprague-Dawley rats (200-250 g)
Dosage:	20 mg/kg (Pharmacokinetic Analysis)
Iv
Result:

YQ128 Preparation Products And Raw materials

Raw materials

Preparation Products

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YQ128 Suppliers

China 26 United States 5 Global 31

Wuhan Acumen Bio-Technology Co.,ltd

Tel: 027-027-16602739303 16602739303
Email: 673003916@qq.com
Country: China
ProdList: 2974
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4589
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
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Shanghai Chaolan Chemical Technology Center

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Shanghai SuperLan Chemcial Technique Centre

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Email: lucy@atkchemical.com
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Shanghai Yu Ben Biotechnology Co., Ltd.

Tel: 15502154572
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Email: yuben012@sina.com
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Shanghai Changyu Medical Technology Co. Ltd.

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Email: sales@changyuhe.com
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Shanghai Han-Xiang Chemical Co., Ltd.

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Email: amber@biochempartner.com
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
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2454246-18-3, YQ128Related Search:

3-Thiopheneacetamide, N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]-

N-[(5-chloro-2-propoxyphenyl)methyl]-N-(2-{4-[(pr op-2-yn-1-yl)sulfamoyl]phenyl}ethyl)-2-(thiophen- 3-yl)acetamide

YQ128

YQ128,inhibit,YQ 128,Inhibitor,NOD-like Receptor (NLR),Interleukin Related,YQ-128

YQ128, 10 mM in DMSO

2454246-18-3

C27H29ClN2O4S2