ChemicalBook > CAS DataBase List > YQ128

YQ128

Product Name
YQ128
CAS No.
2454246-18-3
Chemical Name
YQ128
Synonyms
YQ128;YQ128, 10 mM in DMSO;YQ128,inhibit,YQ 128,Inhibitor,NOD-like Receptor (NLR),Interleukin Related,YQ-128;3-Thiopheneacetamide, N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]-;N-[(5-chloro-2-propoxyphenyl)methyl]-N-(2-{4-[(pr op-2-yn-1-yl)sulfamoyl]phenyl}ethyl)-2-(thiophen- 3-yl)acetamide
CBNumber
CB98199880
Molecular Formula
C27H29ClN2O4S2
Formula Weight
545.11
MOL File
2454246-18-3.mol
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YQ128 Property

Boiling point:
705.8±70.0 °C(Predicted)
Density 
1.287±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 250 mg/mL (458.62 mM)
form 
A crystalline solid
pka
9.32±0.50(Predicted)
color 
White to off-white
InChIKey
SFPYRFRNYALLHS-UHFFFAOYSA-N
SMILES
C1SC=CC=1CC(N(CC1=CC(Cl)=CC=C1OCCC)CCC1=CC=C(S(NCC#C)(=O)=O)C=C1)=O
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0106043
Product name
YQ128
Purity
99.65%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0106043
Product name
YQ128
Purity
99.65%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0106043
Product name
YQ128
Purity
99.65%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0106043
Product name
YQ128
Purity
99.65%
Packaging
100mg
Price
$2250
Updated
2021/12/16
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YQ128 Chemical Properties,Usage,Production

Uses

YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC50 of 0.30 μM. YQ128 significantly and selectively suppresses the production of IL-1β, but not TNF-α, and it can cross the BBB to reach the CNS. YQ128 has anti-inflammatory activity[1]. YQ128 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Biological Activity

YQ128 is a potent and selective second-generation NLRP3 inflammasome inhibitor with IC50 of 0.30 μM. YQ128 significantly and selectively inhibited the production of IL-1β, but not TNF-α. YQ128 can cross the blood-brain barrier to reach the central nervous system. YQ128 has anti-inflammatory activity.

in vitro

YQ128 (0.3-100 μM; 30 mins) dose dependently suppressed the release of IL-1β from peritoneal macrophages upon LPS/ATP challenge with an IC 50 of 1.59 μM.
YQ128 (20 μM; 2 hours) shows no significant toxic effects on hCMEC/D3 cells.

Cell Viability Assay

< td class="col1"> Cell Line:
Mouse peritoneal macrophages
Concentration: 0.3, 1.0, 3.0, 10, 30, 100 μM
Incubation Time: 30 mins
Result: Suppressed the release of IL-1β from peritoneal macrophages upon LPS/ATP challenge with an IC 50 of 1.59 μM.

in vivo

YQ128 (iv; 20 mg/kg) has an intermediate terminal plasma half-life (t 1/2 ) of 6.6 hours after iv administration.
YQ128 (oral ; 20 mg/kg) shows delayed gastrointestinal absorption with at max and c max of 12 h and 73 ng/mL, respectively. Oral bioavailability (F oral < /sub> ) is estimated as 10%.
YQ128 exhibits extensive extravascular distribution with a large steady-state volume of distribution (Vd ss ) of 8.5 L/kg and rapid total clearance (CL tot ) of 41 mL/min/kg.
has been shown to trigger IL-1β production in a NLRP3-dependent manner in C57BL/6 mice. < /p>

< tr> Administration: < td class="col2"> Had an intermediate terminal plasma half-life (t 1/2 ) of 6.6 hours after iv administration.
Animal Model: Sprague-Dawley rats (200-250 g)
Dosage: 20 mg/kg (Pharmacokinetic Analysis)
Iv
Result:

IC 50

NLRP3: 0.30 μM (IC50); IL-1β

YQ128 Preparation Products And Raw materials

Raw materials

Preparation Products

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YQ128 Suppliers

China 35 United States 5 Global 40
Wuhan Acumen Bio-Technology Co.,ltd
Tel
027-027-16602739303 16602739303
Email
673003916@qq.com
Country
China
ProdList
2995
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4797
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2977
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9498
Advantage
58
Shanghai Yu Ben Biotechnology Co., Ltd.
Tel
021-61350663 15502154572
Fax
-
Email
1639466865@qq.com
Country
China
ProdList
497
Advantage
58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
Country
China
ProdList
3061
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58

2454246-18-3, YQ128Related Search:


  • 3-Thiopheneacetamide, N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]-
  • N-[(5-chloro-2-propoxyphenyl)methyl]-N-(2-{4-[(pr op-2-yn-1-yl)sulfamoyl]phenyl}ethyl)-2-(thiophen- 3-yl)acetamide
  • YQ128
  • YQ128,inhibit,YQ 128,Inhibitor,NOD-like Receptor (NLR),Interleukin Related,YQ-128
  • YQ128, 10 mM in DMSO
  • 2454246-18-3
  • C27H29ClN2O4S2