Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-

Product Name: Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-
CAS No.: 2304621-31-4
Chemical Name: Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-
Synonyms: LDC195943(IMT1);IMT1, 10 mM in DMSO;N,N-Dimethyl-2-((2-oxo-4-(o-tolyl)-2H-chromen-7-yl)oxy)propanamide;Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-;NDUFB8,chain,POLRMT,DNA/RNA Synthesis,Inhibitor,OXPHOS,Mitochondrial Metabolism,citric,IMT-1,deoxynucleoside,respiratory,inhibit,IMT1,intermediates,mitochondrial,acid,polymerase,AMP/ATP,UQCRC2,triphosphate,COXI,RNA,mtDNA,IMT 1,AMPK,transcription
CBNumber: CB98215009
Molecular Formula: C21H21NO4
Formula Weight: 351.4
MOL File: 2304621-31-4.mol

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Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]- Property

Boiling point:: 549.7±50.0 °C(Predicted)
Density: 1.210±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (142.29 mM; Need ultrasonic)
form: Solid
pka: -0.84±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0144958
Product name: IMT1
Purity: 98.54%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0144958
Product name: IMT1
Purity: 98.54%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0144958
Product name: IMT1
Purity: 98.54%
Packaging: 25mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0144958
Product name: IMT1
Purity: 98.54%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0144958
Product name: IMT1
Purity: 98.54%
Packaging: 100mg
Price: $1350
Updated: 2021/12/16

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Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]- Chemical Properties,Usage,Production

Uses

IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases[1].

References

[1] Nina A Bonekamp, et al. Small-molecule inhibitors of human mitochondrial DNA transcription. Nature. 2020 Dec;588(7839):712-716. DOI:10.1038/s41586-020-03048-z

Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]- manufacturers

Hu Bei Jiutian Bio-medical Technology CO.,Ltd

Product: Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy] 2304621-31-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20T
Release date: 2025-09-09

2304621-31-4, Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-Related Search:

Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-

LDC195943(IMT1)

NDUFB8,chain,POLRMT,DNA/RNA Synthesis,Inhibitor,OXPHOS,Mitochondrial Metabolism,citric,IMT-1,deoxynucleoside,respiratory,inhibit,IMT1,intermediates,mitochondrial,acid,polymerase,AMP/ATP,UQCRC2,triphosphate,COXI,RNA,mtDNA,IMT 1,AMPK,transcription

N,N-Dimethyl-2-((2-oxo-4-(o-tolyl)-2H-chromen-7-yl)oxy)propanamide

IMT1, 10 mM in DMSO

2304621-31-4