INDEX NAME NOT YET ASSIGNED

Product Name: INDEX NAME NOT YET ASSIGNED
CAS No.: 2376255-48-8
Chemical Name: INDEX NAME NOT YET ASSIGNED
Synonyms: (4S,7S,10S,13S)-4-Benzyl-13-(2-chloroacetyl)-10-((R)-1-hydroxyethyl)-7-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid
CBNumber: CB98225653
Molecular Formula: C26H37ClN4O8
Formula Weight: 569.05
MOL File: 2376255-48-8.mol

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INDEX NAME NOT YET ASSIGNED Property

Boiling point:: 962.7±65.0 °C(Predicted)
Density: 1.275±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C, protect from light, stored under nitrogen
solubility: Soluble to 1 mg/ml in DMSO
pka: 3.93±0.19(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0089824
Product name: Ac-FLTD-CMK
Purity: 99.53%
Packaging: 1mg
Price: $550
Updated: 2021/12/16

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INDEX NAME NOT YET ASSIGNED Chemical Properties,Usage,Production

Biological Activity

Ac-FLTD-CMK is a selective gasdermin D (GSDMD) clevage inhibitor (IC50 = 46.7 nM, 329 nM, 1.49 μM, respectively, against GSDMD clevage by human caspase-1, -5, -4 in cell-free enzymatic assays) th at suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages (10 μM 4h post 200 ng/mL LPS and 0.5h before ATP or nigericin). Ac-FLTD-CMK selectively blocks GSDMD clevage by inflammatory caspases without affecting apoptotic caspases (caspase-3 IC50 >100 μM) or apoptosis.

storage

Store at -20°C

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

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INDEX NAME NOT YET ASSIGNED Suppliers

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2376255-48-8, INDEX NAME NOT YET ASSIGNEDRelated Search:

(4S,7S,10S,13S)-4-Benzyl-13-(2-chloroacetyl)-10-((R)-1-hydroxyethyl)-7-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid

2376255-48-8

C26H37ClN4O8