4-TERT-BUTYL-3,6-DICHLOROPYRIDAZINE
- Product Name
- 4-TERT-BUTYL-3,6-DICHLOROPYRIDAZINE
- CAS No.
- 22808-29-3
- Chemical Name
- 4-TERT-BUTYL-3,6-DICHLOROPYRIDAZINE
- Synonyms
- 4-TERT-BUTYL-3,6-DICHLOROPYRIDAZINE;3,6-Dichloro-4-tert-butylpyridazine;Pyridazine, 4-tert-butyl-3,6-dichloro-;3,6-Dichloro-4-(1,1-dimethylethyl)pyridazine;Pyridazine, 3,6-dichloro-4-(1,1-dimethylethyl)-;4-TERT-BUTYL-3,6-DICHLOROPYRIDAZINE ISO 9001：2015 REACH
- CBNumber
- CB9823118
- Molecular Formula
- C8H10Cl2N2
- Formula Weight
- 205.08
- MOL File
- 22808-29-3.mol
4-TERT-BUTYL-3,6-DICHLOROPYRIDAZINE Property
- Melting point:
- 37-40 °C
- Boiling point:
- 297.3±35.0 °C(Predicted)
- Density
- 1.231
- refractive index
- 1.52
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform, Dichloromethane
- form
- Oil
- pka
- -0.40±0.10(Predicted)
- color
- Colourless
- EPA Substance Registry System
- Pyridazine, 3,6-dichloro-4-(1,1-dimethylethyl)- (22808-29-3)
Safety
- Toxicity
- rat,LDLo,oral,500mg/kg (500mg/kg),SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYEBEHAVIORAL: COMABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,National Technical Information Service. Vol. OTS0544009,
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B691040
- Product name
- 4-tert-Butyl-3,6-dichloropyridazine
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB19490
- Product name
- 4-tert-Butyl-3,6-dichloropyridazine
- Packaging
- 50mg
- Price
- $110.5
- Updated
- 2021/12/16
- Product number
- W4650
- Product name
- 4-tert-Butyl-3,6-dichloropyridazine
- Packaging
- 100mg
- Price
- $116
- Updated
- 2021/12/16
- Product number
- FB19490
- Product name
- 4-tert-Butyl-3,6-dichloropyridazine
- Packaging
- 100mg
- Price
- $201
- Updated
- 2021/12/16
- Product number
- FB19490
- Product name
- 4-tert-Butyl-3,6-dichloropyridazine
- Packaging
- 250mg
- Price
- $365
- Updated
- 2021/12/16
4-TERT-BUTYL-3,6-DICHLOROPYRIDAZINE Chemical Properties,Usage,Production
Chemical Properties
Colourless Oil
Synthesis
141-30-0
75-98-9
22808-29-3
Synthesis of compound J.1. To a 250 mL round bottom flask was added 3,6-dichloropyridazine (1.49 g, 10 mmol, 1.0 eq.), silver nitrate (0.17 g, 1 mmol, 0.1 eq.), deionized water (30 mL), pivalic acid (3.57 g, 35 mmol, 3.5 eq.), and concentrated sulfuric acid (1.6 mL, 30 mmol, 3.0 eq.). The reaction mixture was heated to 70 °C and kept at a constant temperature. An aqueous solution (10 mL) of ammonium persulfate (2.28 g, 10 mmol, 1.0 eq.) was added slowly and dropwise over 10 minutes. After the dropwise addition, the reaction was continued with stirring at 70 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature. The reaction mixture was slowly poured into ice water (100 mL) and the pH was adjusted with aqueous ammonium hydroxide to 8. The aqueous phase was extracted with dichloromethane (3 × 250 mL). The organic phases were combined, filtered through a cotton plug, washed with 1N aqueous NaOH (70 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. Purification of the crude product by fast column chromatography (20% ethyl acetate/hexane) afforded 4-tert-butyl-3,6-dichloropyridazine (1.32 g, 64% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ: 7.5 (s, 1H), 1.5 (s, 9H); Rf = 0.5 (80% ethyl acetate/hexane).
References
[1] Patent: US2009/5359, 2009, A1. Location in patent: Page/Page column 39
[2] Patent: US2009/36419, 2009, A1. Location in patent: Page/Page column 84
[3] Journal of Medicinal Chemistry, 2005, vol. 48, # 23, p. 7089 - 7092
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 20, p. 6030 - 6033
4-TERT-BUTYL-3,6-DICHLOROPYRIDAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-TERT-BUTYL-3,6-DICHLOROPYRIDAZINE manufacturers
- Product
- 4-TERT-BUTYL-3,6-DICHLOROPYRIDAZINE 22808-29-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-08