TIMTEC-BB SBB005393

Product Name: TIMTEC-BB SBB005393
CAS No.: 72214-67-6
Chemical Name: TIMTEC-BB SBB005393
Synonyms: TIMTEC-BB SBB005393;RRD-251 hydrochloride;Rb/Raf-1 Disruptor 251;Rb/Raf-1 disruptor 251 hydrochloride;Rb/Raf-1 Disruptor 251;[(2,4-dichlorobenzyl)thio]formamidine hydrochloride;S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride;2,4-dichlorobenzyl imidothiocarbamate hydrochloride;2,4-Dichlorobenzyl carbamimidothioate hydrochloride;2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride
CBNumber: CB9824650
Molecular Formula: C8H9Cl3N2S
Formula Weight: 271.6
MOL File: 72214-67-6.mol

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TIMTEC-BB SBB005393 Property

Melting point:: 222-227 °C
storage temp.: room temp
solubility: DMSO: >10mg/mL
form: White solid
color: white to off-white

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2930909899

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R7532
Product name: RRD-251 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $55.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 559270
Product name: RRD-251 hydrochloride
Packaging: 25mg
Price: $143
Updated: 2022/05/15

Sigma-Aldrich

Product number: R7532
Product name: RRD-251 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $214
Updated: 2025/07/31

TRC

Product number: D454458
Product name: RRD-251 hydrochloride
Packaging: 10mg
Price: $70
Updated: 2021/12/16

TRC

Product number: D454458
Product name: RRD-251 hydrochloride
Packaging: 5mg
Price: $40
Updated: 2021/12/16

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TIMTEC-BB SBB005393 Chemical Properties,Usage,Production

Uses

RRD-251 Hydrochloride is a reversible selective disruptor of Rb-Raf-1 interaction.

Biological Activity

RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.

in vivo

RRD-251 (50 mg/kg; i.p.; q.o.d; for 14 days) has anti-cancer activities in vivo on melanomas^[1].

Animal Model:	8-wk-old female athymic nude mice, with SK-ME-28 xenograft^[1]
Dosage:	50 mg/kg
Administration:	Intraperitoneal administration, qod, for 14 days
Result:	Inhibits the growth of SK-ME-28 xenograft in nude mice.

TIMTEC-BB SBB005393 Preparation Products And Raw materials

Raw materials

Preparation Products

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TIMTEC-BB SBB005393 Suppliers

China 21 United Kingdom 1 United States 5 Global 27

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RD International Technology Co., Limited

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72214-67-6, TIMTEC-BB SBB005393Related Search:

TIMTEC-BB SBB005393

(2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride

2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride

Rb/Raf-1 disruptor 251 hydrochloride

RRD-251 hydrochloride

S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride

(2,4-dichlorophenyl)methylsulfanylformamidine hydrochloride

(2,4-dichlorophenyl)methylsulfanylmethanimidamide hydrochloride

Rb/Raf-1 Disruptor 251

[(2,4-dichlorobenzyl)thio]formamidine hydrochloride

[(2,4-dichlorophenyl)methylthio]formamidine hydrochloride

2,4-dichlorobenzyl imidothiocarbamate hydrochloride

2-(2,4-Dichlorobenzyl)thiourea hydrochloride RRD-251 hydrochloride

2,4-Dichlorobenzyl carbamimidothioate hydrochloride

Rb/Raf-1 Disruptor 251

72214-67-6