TIMTEC-BB SBB005393

Product Name: TIMTEC-BB SBB005393
CAS No.: 72214-67-6
Chemical Name: TIMTEC-BB SBB005393
Synonyms: TIMTEC-BB SBB005393;RRD-251 hydrochloride;Rb/Raf-1 Disruptor 251;Rb/Raf-1 disruptor 251 hydrochloride;Rb/Raf-1 Disruptor 251;[(2,4-dichlorobenzyl)thio]formamidine hydrochloride;S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride;2,4-dichlorobenzyl imidothiocarbamate hydrochloride;2,4-Dichlorobenzyl carbamimidothioate hydrochloride;2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride
CBNumber: CB9824650
Molecular Formula: C8H9Cl3N2S
Formula Weight: 271.6
MOL File: 72214-67-6.mol

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TIMTEC-BB SBB005393 Property

Melting point:: 222-227 °C
storage temp.: room temp
solubility: DMSO: >10mg/mL
form: White solid
color: white to off-white

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2930909899

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R7532
Product name: RRD-251 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $54.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 559270
Product name: RRD-251 hydrochloride
Packaging: 25mg
Price: $143
Updated: 2022/05/15

Sigma-Aldrich

Product number: R7532
Product name: RRD-251 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $208
Updated: 2024/03/01

TRC

Product number: D454458
Product name: RRD-251 hydrochloride
Packaging: 10mg
Price: $70
Updated: 2021/12/16

TRC

Product number: D454458
Product name: RRD-251 hydrochloride
Packaging: 5mg
Price: $40
Updated: 2021/12/16

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TIMTEC-BB SBB005393 Chemical Properties,Usage,Production

Uses

RRD-251 Hydrochloride is a reversible selective disruptor of Rb-Raf-1 interaction.

Biological Activity

RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.

TIMTEC-BB SBB005393 Preparation Products And Raw materials

Raw materials

Preparation Products

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TIMTEC-BB SBB005393 Suppliers

China 20 United Kingdom 1 United States 5 Global 26

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
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Email: info@efebio.com
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Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
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Nanjing Shizhou Biology Technology Co.,Ltd

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Shanghai Xiushi Biomedical Co., LTD

Tel: 15021598081,571034478; 15021598081
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Nanjing Shizhou Biology Technology Co.,Ltd

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Shanghai Universal Biotech Co.,Ltd

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Bide Pharmatech Ltd.

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Email: product02@bidepharm.com
Country: China
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
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Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 15162312715
Email: sales@szzxbio.com
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Nantong QuanYi Biotechnology Co., Ltd

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Email: sales@chemhifuture.com
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72214-67-6, TIMTEC-BB SBB005393Related Search:

TIMTEC-BB SBB005393

(2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride

2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride

Rb/Raf-1 disruptor 251 hydrochloride

RRD-251 hydrochloride

S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride

(2,4-dichlorophenyl)methylsulfanylformamidine hydrochloride

(2,4-dichlorophenyl)methylsulfanylmethanimidamide hydrochloride

Rb/Raf-1 Disruptor 251

[(2,4-dichlorobenzyl)thio]formamidine hydrochloride

[(2,4-dichlorophenyl)methylthio]formamidine hydrochloride

2,4-dichlorobenzyl imidothiocarbamate hydrochloride

2-(2,4-Dichlorobenzyl)thiourea hydrochloride RRD-251 hydrochloride

2,4-Dichlorobenzyl carbamimidothioate hydrochloride

Rb/Raf-1 Disruptor 251

72214-67-6