ETHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE

Product Name: ETHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE
CAS No.: 425392-44-5
Chemical Name: ETHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE
Synonyms: ethyl 2-bromo-5-chloro-4-thiazolecarboxylate;ETHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE;2-Bromo-5-chloro-4-(ethoxycarbonyl)-1,3-thiazole;Ethyl 2-bromo-5-chloro-1,3-thiazole-4-carboxylate;2-Bromo-5-chloro-1,3-thiazol-4-carboxylic ethyl ester;2-Bromo-5-chloro-4-thiazolecarboxylic acid ethyl ester;2-Bromo-5-chloro-thiazole-4-carboxylic acid ethyl ester;4-Thiazolecarboxylic acid, 2-bromo-5-chloro-, ethyl ester;Ethyl 2-bromo-5-chloro-1,3-thiazole-4-carboxylate - [E9340];2-(1-(4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazine-1-carbonyl)cyclobutyl)acetic acid
CBNumber: CB9825369
Molecular Formula: C6H5BrClNO2S
Formula Weight: 270.53
MOL File: Mol file

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ETHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE Property

Boiling point:: 313℃
Density: 1.749
Flash point:: 143℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.22±0.10(Predicted)
form: powder
color: Off-white

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Safety

HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: Y5430
Product name: Ethyl2-bromo-5-chlorothiazole-4-carboxylate
Packaging: 250mg
Price: $131
Updated: 2021/12/16

Apolloscientific

Product number: OR60060
Product name: Ethyl2-bromo-5-chloro-1,3-thiazole-4-carboxylate
Packaging: 1g
Price: $150
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H70-D-X0
Product name: Ethyl 2-bromo-5-chloro-1,3-thiazole-4-carboxylate
Purity: 95.0%
Packaging: 1g
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: Y5430
Product name: Ethyl2-bromo-5-chlorothiazole-4-carboxylate
Packaging: 1g
Price: $218
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0351087
Product name: ETHYL-2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $502.91
Updated: 2021/12/16

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ETHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

136539-01-0

425392-44-5

Ethyl 2-amino-5-chloro-1,3-thiazole-4-carboxylate (2.00 g, 9.678 mmol, 1.00 eq.) was used as starting material, which was mixed with tert-butyl nitrite (1.20 g, 11.637 mmol, 1.20 eq.) and copper bromide (2.59 g, 11.596 mmol, 1.20 eq.) in acetonitrile (50 mL). The reaction mixture was stirred at 80 °C for 2 hours. After completion of the reaction, the resulting solution was concentrated under vacuum and the obtained residue was purified by silica gel column chromatography with the eluent dichloromethane/methanol (40:1, v/v), resulting in the target compound ethyl 2-bromo-5-chlorothiazole-4-carboxylate (1.2 g, 46% yield) as a white solid. The product was confirmed by LC-MS (electrospray ionization, m/z) analysis: 270 [M + H]+.

References

[1] Organic Letters, 2003, vol. 5, # 16, p. 2911 - 2914
[2] Organic Letters, 2002, vol. 4, # 8, p. 1363 - 1365
[3] Patent: WO2016/135163, 2016, A1. Location in patent: Paragraph 0209
[4] Tetrahedron Letters, 2002, vol. 43, # 39, p. 7051 - 7053
[5] Patent: WO2010/122504, 2010, A1. Location in patent: Page/Page column 54

ETHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE Suppliers

China 80 India 1 United Kingdom 2 United States 9 Global 92

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
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Country: China
ProdList: 9976
Advantage: 60

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
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Country: United States
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ZEROSCHEM.CO.,LTD.

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Country: China
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Chemsky（shanghai）International Co.,Ltd.

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Email: shchemsky@sina.com
Country: China
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Wuhan Arike Technology Co., Ltd.

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Fax: E-Mail Inquiry
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Heterochem

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Chiba Pharmaceutical Science and technology Co, Ltd.

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SuZhou ShiYa Biopharmaceuticals, Inc.

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Wuhan Kaymke Chemical Co., Ltd.,

Tel: 027-027-87342388 18086026008
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Nantong Bosu Pharmaceutical Technology Co., Ltd.

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View Lastest Price from ETHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: ETHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE 425392-44-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-08-07

425392-44-5, ETHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATERelated Search:

5-CHLORO-THIAZOLE

ETHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE

2-Bromo-5-chloro-1,3-thiazol-4-carboxylic ethyl ester

Ethyl 2-bromo-5-chloro-1,3-thiazole-4-carboxylate

2-Bromo-5-chloro-4-(ethoxycarbonyl)-1,3-thiazole

2-Bromo-5-chloro-4-thiazolecarboxylic acid ethyl ester

4-Thiazolecarboxylic acid, 2-bromo-5-chloro-, ethyl ester

2-(1-(4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazine-1-carbonyl)cyclobutyl)acetic acid

2-Bromo-5-chloro-thiazole-4-carboxylic acid ethyl ester

ethyl 2-bromo-5-chloro-4-thiazolecarboxylate

Ethyl 2-bromo-5-chloro-1,3-thiazole-4-carboxylate - [E9340]

425392-44-5

Building Blocks

Thiazole